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This position is an outstanding opportunity for a highly motivated candidate to join as a Staff Scientist in Dr. Ji Sun’s group in the Structural Department. Dr. Sun's laboratory will focus on the structure and function of important membrane proteins and protein complexes. For more details about Dr. Sun’s previous research, please check his publications. In this position, you will   ·     design and perform complex experiments and analyze data independently.   ·     develop new experimental procedures and publish research results  ·     train and supervise lab members on relevant laboratory procedures and techniques.  ·     assist with day-to-day operation of the lab  Strong background in structure biology, biochemistry or related fields and training in cryo-EM or membrane protein biology preferred.     
Job ID
42257
Department
Structural Biology
Company
St. Jude Children's Research Hospital
At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.   The laboratory of Dr.Chia-Hsueh Lee in the Structural Biology Department strives to elucidate the molecular mechanism and function of membrane signaling complexes using cryo-EM and biochemical/biophysical approaches. The lab has full access to the state-of-the-art cryoEM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope, both equipped with a K3 detector and energy filter. We are seeking a highly motivated staff research scientist to join Dr. Lee’s lab at SJCRH. This scientist will lead research projects focusing on structural mechanisms of neuronal membrane proteins and assist Dr. Lee with lab operations. The ideal candidate should have good communication skills and a collaborative attitude. Project management, scientific writing and expertise in structural biology (single particle cryo-EM or X-ray crystallography) would be a plus.    
Job ID
42711
Department
Structural Biology
Company
St. Jude Children's Research Hospital
During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases. At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. St. Jude Children Research Hospital ensures that scientific progress is never halted from a lack of resources. We are building on that success with a comprehensive strategy to expand our mission, including our reach around the world.    The Center for In Vivo Imaging and Therapeutics (CIVIT) acts to combine state-of-the-art imaging technologies, preclinical model development, and advanced technical expertise to support investigator-led research efforts. The CIVIT is an institutional shared resource and valuable partner in the development of new therapeutic approaches at St. Jude and plays a pivotal role in strategic research initiatives toward the identification of new targets and translation of novel therapeutic approaches. St. Jude Children’s Research Hospital is committed to the establishment of a dedicated team of talented research staff supporting our preclinical efforts in translational research and seeks to identify and recruit outstanding individuals to meet the research goals of our faculty.   This preclinical therapeutics initiative partners with cancer center programs of the St Jude Comprehensive Cancer Center, and utilizes a spectrum of state-of-the-art preclinical resources, including surgery, imaging and pharmacokinetics, to achieve its goal of translating basic science findings toward improving clinical outcomes in children with catastrophic diseases. The initiative is a critical component of our strategic direction and will ultimately be located in custom designed space in our new Advanced Research Center location, scheduled to be occupied in Spring of 2021.  
Job ID
42742
Department
Center for InVivo Imaging & Therapy
Company
St. Jude Children's Research Hospital
St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, with an emphasis on pediatric cancer, in order to facilitate therapeutic advances and improve life quality and expectancy of patients. The Single-Molecule Imaging Center in the Department of Structural Biology provides a platform to perform state-of-the-art single-molecule fluorescence experiments on medically relevant biological systems. Core instrumentation currently includes prism-type total internal reflection fluorescence (TIRF) and time-correlated single-photon counting (TCSPC) confocal microscopes. The successful applicant will leverage their expertise in optics, engineering, and data science by developing advanced microscopy methods that improve data quality, throughput, automation, and downstream analysis, including machine learning methods. The applicant must skillfully translate ideas into robust, effective, and user-friendly solutions for the non-expert. The successful candidate will be an integral part of the progression of the Center, introducing the single-molecule field to experimentalists at St. Jude and worldwide.   Relevant references: - Fitzgerald and Terry et al. Quantifying secondary transport at single-molecule resolution. Nature 575, 528-534 (2019). - Borgia et al. Extreme disorder in an ultrahigh-affinity protein complex. Nature 555, 61-66 (2018). - Dyla and Terry et al. Dynamics of P-type ATPase transport revealed by single-molecule FRET. Nature 551, 346-351 (2017). - Gregorio et al. Single-molecule analysis of ligand efficacy in β2AR-G-protein activation. Nature 547, 68-73 (2017). - Juette and Terry et al. Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale. Nat. Methods 13, 341-4 (2016). - Borgia et al. Consistent View of Polypeptide Chain Expansion in Chemical Denaturants from Multiple Experimental Methods. J. Am. Chem. Soc.  138, 11714-11726 (2016).
Job ID
42957
Department
Structural Biology
Company
St. Jude Children's Research Hospital
We are seeking for a Research Technologist to focus on translational research support for pediatric solid tumor and brain tumor programs as directed by the DNB Director of Operations and Chair. This position involves assisting with the collection and processing of biological specimens, routine colony maintenance and administration of substances techniques, facilitates specimen inventory and sample shipping worldwide, and maintains detailed records of ongoing scientific projects. Additionally, this person will interact with multiple institutional departments and collaborate on projects and initiatives. Assists with the management of laboratory operations. Performs other related duties as assigned or directed in order to meet the goals and objectives of the department.   *Position will require occasional work after hours, on call and on weekends/holidays (rotational).  
Job ID
42987
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
We are seeking a Research Technologist or Senior Research Technologist in the laboratory of Dr. Jun Yang at St. Jude Children's Research Hospital. This person will be responsible for assisting the principal investigator and postdoctoral fellows with the data collection and analysis for research projects related to pharmacogenomics. He/she is expected to perform or participate in wet-lab experiments using a variety of model systems, and also to directly work with patient materials for translational research projects (e.g., sample collection and processing in the context of clinical trials). Other duties include maintaining efficient laboratory operations and training other laboratory personnel and activities directed by supervisor in order to meet the goals and objectives of the department.   Previous background in molecular biology (e.g. cloning, RNA and protein analyses) and cell biology (e.g. cell culture, shRNA transfection, drug sensitivity testing) is highly preferred. Efficient and effective communication and strong organizational skills are essential for this position.   Research at Dr. Yang's laboratory is highly translational, offering outstanding opportunities to learn a wide array of techniques across diverse disciplines (from basic cancer biology, drug development and evaluation, to preclinical and early clinical studies of novel therapy).  
Job ID
43015
Department
Pharmaceutical Sciences
Company
St. Jude Children's Research Hospital
The Obeng Laboratory is part of the Department of Oncology at St. Jude Children’s Research Hospital in Memphis, TN. Research in the Obeng lab centers on the pathogenesis of myeloid malignancies. Myelodysplastic syndromes (MDS) are a pre-leukemic group of blood stem cell disorders with limited treatment options and a high risk of progression to leukemia. RNA splicing factor mutations and epigenetic regulator mutations are common and early events in MDS pathogenesis. The major interests of the Obeng lab are (1) determining how mutations in components of the mRNA spliceosome and epigenetic regulators cooperate to cause clonal hematopoiesis and leukemia, (2) identifying and studying novel treatments that selectively target malignant cells.
Job ID
43136
Department
Oncology
Company
St. Jude Children's Research Hospital
The Cell and Tissue Imaging Center at St. Jude Children’s Research Hospital is looking for a talented and driven electron microscopist to join the Center at the Associate Scientist level.   The electron microscopy facility houses a Thermo Fisher Scientific F20, a Helios FIB/SEM and a Teneo VolumeScope SEM as well as a variety of equipment for sample preparation including Leica tissue processors and ultramicrotomes, equipment for low temperature processing and multiple vacuum evaporators. The facility is funded by the Hospital and is utilized by faculty from across the research departments, providing world class imaging to the investigators at St. Jude. Staff members in the Center collaborate with investigators on a variety of research projects from standard tissue pathologies through three-dimensional imaging projects by electron tomography or volume SEM and have the opportunity to participate in development of techniques and protocols to drive St. Jude’s research forward.   This position requires experience in biological electron microscopy. Skill sets in volume SEM (scanning block face SEM, array tomography, and FIB/SEM) and/or high pressure freezing and freeze substitution are highly desirable.     
Job ID
43138
Department
Cellular Imaging Shared Resources
Company
St. Jude Children's Research Hospital
St. Jude Children’s Research Hospital will provide you with world-class facilities, state-of-the-art technologies, and extraordinary support to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your work translates into survival for the children we serve.  
Job ID
43170
Department
Pharmaceutical Sciences
Company
St. Jude Children's Research Hospital
Focuses on one or more specific scientific endeavors of the laboratory as directed by the Associate or Full Member. Utilizes unique, advanced skills in achieving the highest research goals. Develops new experimental procedures and publishes research results. Initiates and conducts independent experiments without direct supervision. Assists with the management of laboratory operations. Performs other related duties as assigned or directed in order to meet the goals and objectives of the department.
Job ID
43238
Department
Hematology
Company
St. Jude Children's Research Hospital
The Hematology Department at the St. Jude Children's Research Hospital is committed to the treatment and understanding of blood disorders and blood cell development. We are seeking a Flow Cytometry Specialist as a Research Lab Specialist or Sr. Research Technologist to join our new Flow Cytometry Departmental Facility. The applicant should have broad experience in flow cytometry, will be expected to work independently, and will interact with many individuals from our Experimental Hematology Research Groups.    
Job ID
43239
Department
Hematology
Company
St. Jude Children's Research Hospital
The Biostatistician/Senior Biostatistician will have a direct impact on the mission of St. Jude Children’s Research Hospital to advance cures for pediatric catastrophic diseases by providing statistical knowledge and expertise to St. Jude researchers conducting clinical and experimental studies. The Department of Biostatistics is a large department with 14 faculty (PhD level) statisticians, 26 master’s level statisticians, 3 postdoctoral fellows, 8 computer scientists, and administrative staff. Master’s level biostatisticians work in teams with a faculty member and sometimes with other biostatisticians to support assigned specific research areas. This approach enables the successful candidate to gain disease-specific knowledge and expertise and to build productive relationships with collaborators across St. Jude.
Job ID
F1167
Department
Biostatistics
Company
St. Jude Children's Research Hospital
The Immunology department at St. Jude Children's Research Hospital is seeking a System Immunology Specialist to assists with the curation, integration, and analysis of immunology, oncology, and cancer immunology data using methods from computational and systems biology. Other activities include assisting in the development, implementation, and maintenance of computational biology and immunology databases. Additionally performing routine bioinformatics and systems biology tasks.
Job ID
43284
Department
Immunology
Company
St. Jude Children's Research Hospital
Operates as an advanced-level Research Technologist by assisting the principal investigator with the data collection and analysis for research projects. Properly conducts specific projects, maintains efficient laboratory operations and may assist in training other laboratory personnel. Performs other duties as assigned or directed in order to meet the goals and objectives of the department.
Job ID
42681
Department
Ctr for InVivo Imag & Therap
Company
St. Jude Children's Research Hospital
During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases. At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. St. Jude Children Research Hospital ensures that scientific progress is never halted from a lack of resources. We are building on that success with a comprehensive strategy to expand our mission, including our reach around the world.   St. Jude Children’s Research Hospital is committed to investing in and implementing imaging technologies to support basic scientific and translational research. An integral part of this infrastructure has been the establishment of a dynamic light microscopy facility that is home to some of the latest technology in the field including an array of confocal and multi-photon systems, super-resolution technology and whole slide scanning instrumentation. State-of-the art ancillary equipment supporting all platforms and an energetic, talented, multi-disciplinary team to staff the facility synergize together to support the research endeavors of the faculty at St. Jude.   <video src="https://players.brightcove.net/1942203451001/rJ5hfo9P_default/index.html?videoId=6115042882001" target="_blank" title="Core Microscopy Lab" rel="noopener"><img src="https://stjude.icims.com/icims2/servlet/icims2?module=AppInert&amp;action=download&amp;id=190787&amp;hashed=-186045206" alt="Core Microscopy Lab" width="258" height="143" /></video> Core Microscopy Lab overview video (video might take a few seconds to load)  
Job ID
42824
Department
Cellular Imaging Shared Res
Company
St. Jude Children's Research Hospital
At St. Jude Children’s Research Hospital we collect and analyze significant amounts of data that can be used to discover better treatments and cures for catastrophic childhood illnesses. The Department of Epidemiology & Cancer Control has an additional interest in the study of long-term effects of such illnesses and their treatment. This position will serve as a member of our Databases and System team alongside existing data specialists and research coordinators. We are looking for a focused, detailed driven individual to coordinate diverse data sets in support of our survivorship research teams. This individual must be able to independently integrate, assemble, manipulate, summarize, document, and disseminate data from numerous disparate systems. In addition, this individual must be comfortable communicating with clinicians, epidemiologists, behavioral scientists, statisticians, and other research staff concerning various study data points. The best candidate for this position will be very comfortable programming in SAS daily and would be familiar with Tableau, SQL and R, working in clinical and longitudinal research data.
Job ID
42350
Department
Epidemiology & Cancer Control
Company
St. Jude Children's Research Hospital
At St. Jude Children’s Research Hospital our mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Therefore, every one of our professionals shares our commitment to make a difference in the lives of the children we serve.   We are looking for an experienced scientist to join the Department of Epidemiology and Cancer Control where our research is focused on describing late sequelae of childhood cancer and its treatment, and on identification of risk factors that can be modified to prevent these sequelae to promote well-being of childhood cancer survivors. Our department houses two large cohort studies, the Childhood Cancer Survivor Study, and the St. Jude Lifetime Cohort Study.  Our faculty investigators are epidemiologists, biostatisticians, psychologists, physicians, and computational biologists. We conduct observational and interventional research where our expertise incorporates pediatric cancer survivorship, clinical outcomes ascertainment, behavioral and neuropsychology, exercise science and nutrition, psychometrics, computational biology, risk prediction modeling and genetics. We collaborate with clinicians and scientists across the institution and are active members of the Comprehensive Cancer Center. The ideal candidate will have strong background in genetic and clinical epidemiology and analytic experience of whole genome sequencing, GWAS SNPs, bioinformatics, and clinical research data.
Job ID
43144
Department
Epidemiology & Cancer Control
Company
St. Jude Children's Research Hospital
The Obeng Lab is seeking a highly motivated, team-oriented, and creative Staff Scientist to join them as an integral part of the St. Jude research community. The focus of the Obeng Lab is myeloid malignancies. We are specifically interested in how acquired mutations in hematopoietic stem cells block mature blood cell differentiation and/or cause leukemic transformation. We are using a variety of in vivo and in vitro model systems to study the functional consequences of RNA splicing factor and epigenetic modifier mutations on stem cell function and to identify new targeted therapies for myeloid diseases. Successful applicants will respond well to a busy and dynamic lab environment and possess the skills to diligently manage both experiments and personnel within the laboratory. They will possess strong organizational and communication skills. This position requires expertise in hematopoietic stem cell research, cell culture, colony management, and strong flow cytometry skills. The ideal candidate must be able to design and perform experiments with minimal supervision and be interested in learning and applying new techniques from the literature. A background in hematopoiesis research is a plus.  
Job ID
42989
Department
Oncology
Company
St. Jude Children's Research Hospital
St. Jude Children's Research Hospital is consistently ranked on Fortune Magazine's "100 Best Places to Work For" list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve.   We are looking for a Medical Technologist II in the area of Clinical Microbiology to be responsible for the prompt, efficient, and accurate performance, validation, and reporting of laboratory test results which are utilized for the purpose of prognosis, diagnosis, treatment, and research. Under the direct supervision of the Director, Manager or Supervisor, the MT II is responsible for the assigned shift as scheduled. Employee must meet the qualifications as defined in CLIA requirements 42 CFR Part 493 for one or more of the following roles based on education, experience and responsibilities, performed by specific incumbent, within the job: Technical Consultant, Technical Supervisor, General Supervisor and/or Testing personnel.    *Experience with microbiological, molecular microbiological and immunological testing is highly desired. Schedule: Monday-Friday 1 pm - 9 pm with on-call rotation.
Job ID
43078
Department
Pathology
Company
St. Jude Children's Research Hospital

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