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Overview There is a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list.  At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve.  There is a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases.  The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers.    About the position Ideal candidate will have 4+ years of experience in clinical biomedical and/or behavioral research.   The Clinical Research Associate III operates under general supervision and performs activities consistent with those of a Study Coordinator role, namely maintenance of protocol portfolio(s), informed consent(s) and preparation/submission of complex study documents.  This position also performs data abstraction, collection, and entry to support clinical research and prepares submission for all reportable events.  The selected candidate develops, maintains, and/or monitors case report forms and ensures compliance with prescribed interventions and evaluations of the assigned protocol(s).  Provision of data to the collaborating research organization or study sponsor and preparation of complex data reports as well as serving as a mentor and preceptor to staff are also key responsibilities.   About the Department of Radiation Oncology Known for setting standards in technical delivery of radiotherapy and clinical trials, the Department of Radiation Oncology is a full-service department dedicated to clinical research and treatment of 300 children, adolescents, and young adults each year.  With the mission of providing expert and compassionate clinical care, the department is the largest group of experts devoted to pediatric radiation oncology who collectively treat more children than any other cancer center or hospital in the country.  The department includes: -  Multidisciplinary team: Pediatric radiation oncologists, physicists, dosimetrists, radiation therapists, registered nurses, nurse  practitioners as well as supportive research teams (anesthesia, sedation, social work and child life specialists to name a few). -  World-class resources: This includes the first worldwide installation of detector-based spectral CT and digital PET/CT in a  Radiation Oncology Department, state-of-the-art 1.5T and 3T MR scanners (radiotherapy simulators), a dedicated PET/CT and  the world’s first proton therapy center with pencil beam scanning technology designated solely for the treatment of pediatric  cancer. -  State-of-art facility: The department has 20,000 square feet of clinical space that includes a clinic, treatment planning, therapy,  anesthesia and sedation support.  There are two linear accelerator systems with image-guidance, a HDR/fluoroscopy suite, and  spectral CT and 1.5T MR systems dedicated to treatment planning.  The adjacent 25,000 square feet St. Jude Red Frog Events   Proton Therapy Center includes two gantry rooms and a fixed beam room; each equipped with high-precision patient positioning,  volumetric image-guidance systems, and dedicated scanning nozzles. About Memphis This position is based in Memphis, TN; relocation assistance is available. Memphis is a family-friendly metropolitan area that more than a million residents call home.  Memphis is recognized for its world-class music, food and hospitality.  Cost of living is one of our biggest attractions; in fact, Money listed Memphis as one of the least expensive cities in which to raise a child.  Mild winters and beautiful green spaces make the city a magnet for outdoor enthusiasts – there are over 200 miles of bike-friendly lanes with more being added.  Forbes recently named Memphis the 4th happiest city in which to work.  Why live anywhere else?   Work Schedule: Monday-Friday 8am-5pm   Take the first step to join our team by applying now!  
Job ID
43732
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Chemical Biology & Therapeutics is looking for an experienced manager to manage and operate the Compound Management (CM) Center. The CM center is comprised of a team of scientists and biomedical engineers who curate the valuable St. Jude small molecule library, using state-of-the-art automation and electronic data management systems. The library has an active inventory of greater than 650,000 compounds stored in a sub-zero robotic environment. The library is continuously updated and accessed by researchers across campus, to aid in their search for new cures to pediatric catastrophic diseases. The CM center team interacts extensively with the deparment's Discovery Centers, scientists from multiple labs and departments across the institution's campus and external collaborators.  Skills and experience in project management, process and infrastructure design, optimization, and implementation are utilized daily. 
Job ID
47808
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children's Research Hospital is consistently ranked on Fortune Magazine's "100 Best Places to Work For" list because at our extraordinary pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve. The Medical Imaging Scientist leads the development and implementation of diffusion weighted MR imaging based structural connectome assessments in children treated for cancer.  Focuses on identification, visualization, and analysis of brain networks impacted by disease and therapy.  Applies machine learning approaches to structural connectomes for group analyses and pattern recognition.  Collaborates with staff and faculty members within and outside the Structural Connectome Imaging Research (SCIR) Hub on research projects and grant applications.  Collects, documents, organizes, and maintains data obtained from medical imaging studies.  Provides oversight for postdoctoral fellows, research assistants and students in the research laboratory.  Actively participates in scientific journal publications and professional conference presentations.   
Job ID
47995
Department
Diagnostic Imaging
Company
St. Jude Children's Research Hospital
Type
Full Time
There is a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list.  At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve.  There is a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases.  The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers. We are looking for someone who can develop applications in multiple programming languages with the goal of supporting the highest level of clinical care and research in pediatric radiation oncology and to improve outcomes for children that require photon and proton radiation therapy.   We build extensions to vendor systems using languages such as Java, C#, and MATLAB.  We also build custom software and databases using Postgres, Python, C++, R, PHP (Laravel), and JavaScript (Vue/React).  This role is not solely software development. The ideal candidate will be able to work with unfamiliar systems and learn enough about them to determine whether we are using them optimally.  The Systems Analyst might schedule training, talk with vendors, or read documentation to determine if there are better tools out there for our needs.  We need the person to become a super user of our systems and help us get the most out of them.   It is not required that the Systems Analyst be an expert programmer or that the person already know how to do anything related to radiation oncology or medical imaging.  CT, MR, and PET imaging modalities are critical to treatment planning, delivery, and response assessment.  It is required, however, that the employee be willing and able to learn these things as needed (with help from us of course) and that the person can collaborate with others.  This position requires frequent interaction with and support of domain experts such as radiation oncologists, medical physicists, medical dosimetrists, and research staff.  It is imperative that the the employee be able to work actively and constructively with them to develop processes and programs that aid their work.   This role is well positioned to make many important contributions to pediatric cancer treatment.   Work Schedule: Monday-Friday 8am - 5pm   Take the first step to join our team by applying now!  
Job ID
48210
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
There is a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list.  At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve.  There is a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases.  The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers. Job Summary: Manages several large and complex biological research projects that span multiple departments at St. Jude and ensures alignment with the Cancer Center and institutional strategic plan. Manages preclinical testing for the Hematological Malignancies Program (HMP) and the PROPEL portal of leukemia xenografts. Manages all external and internal academic collaborations, including collaborative grants, oversees all government contracts and collaborations, and serves as a liaison between St. Jude and pharmaceutical companies for preclinical studies.   Job Responsibilities: 1. Manages all activities for large and complex research projects   a. Designs, updates, and manages project website   b. Processes internal and external requests including all Material Transfer Agreements (MTAs) and Confidential Disclosure Agreements (CDAs)   c. Manages internal SharePoint web site   d. Manages sample inventory   e. Stays abreast of all laws regarding international shipment of samples and manages said shipments   f. Writes and maintains policy and procedure manual(s) 2. Manages preclinical testing for the Hematologic Malignancies Program (HMP).   a. Manages all projects for preclinical testing including coordinating efforts of Preclinical Pharmacokinetics Shared Resource (P-         PKSR), compound management core in Chemical Biology Therapeutics, Small animal imaging core (CIVIT), Flow Cytometry core,      and Veterinary Pathology Shared Resource   b. Manages and reports on budget for all preclinical testing and provides reports to leadership   c. Maintains data from preclinical testing SharePoint site   d. Provides preclinical testing data to internal and external investigators 3. Manages all external and internal academic collaborations.   a. Manages the sharing of data and samples with domestic and international investigators   b. Point of contact for implementation and development of program data portal (PROPEL). Liaises with institutional stakeholders         ranging from research personnel, Center for Applied Bioinformatics, Research Information Services, Computational Biology,           Biomedical Communications, Office of Tech Licensing.   c. Responds to all logistical and scientific queries regarding samples and data. Facilitates approval of sample request by the     preclinical testing program review committee. Manages sample quality assurance, shipment paperwork, collaboration agreements,     and communication with requesters   d. Works with the Legal Department to develop contracts, MTAs, and CDAs involved in internal and external collaborations   e. Monitors collaborators' compliance with MTAs and CDAs 4. Oversees all government contracts and collaborations   a. Ensures regulatory and financial compliance between St. Jude and its collaborating centers and government agencies   b. Coordinates team visits between institutions   c. Creates protocols and procedures governing the collaborations   d. Manages data sharing in public repositories 5. Serves as a liaison between St. Jude and pharmaceutical companies for preclinical studies   a. Coordinates requests for drugs, reagents and data including negotiation of CDAs and MTAs   b. Ensures documentation is accurate and reports to companies as specified in the MTA and CDA 6. Manages all compliance regarding human stem cells including human embryonic stem cells and patient-derived induced pluripotent     stem cells 7. Manages program budgets and billing for all contracts and collaborations 8. Performs other related duties as assigned to meet the goals of the department and institution 9. Maintains regular and predictable attendance   Special Skills, Knowledge and Abilities: ● Skill and ability to effectively communicate verbally and in writing ● Ability to demonstrate strong leadership ● Knowledge of managerial practices ● Independent, detail oriented and self-motivated with excellent organizational skills ● Ability to assess situations, consider alternatives, and choose appropriate course of action   Physical Demands and Working Conditions: 1. The physical demands described here are representative of those that must be met by an employee to successfully perform the        essential functions of this job 2. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions 3. While performing the duties of this job, the employee is regularly required to stand; walk; sit; kneel, use hands to finger, handle, or      feel; and talk or hear 4. The employee must frequently lift and/or move up to 50 pounds 5. Specific vision abilities required by this job include close vision, depth perception, and ability to adjust focus 6. The employee must move about the work space to access work surface and shelves, cabinets, drawers, and equipment that are at,     below or above the work surface 7. The work environment characteristics described here are representative of those an employee encounters while performing the        essential functions of this job 8. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions 9. An essential function of the job is to be able to comply with all applicable federal, state and local safety and health regulations that     would apply to this job 10. Nothing in this job description limits management's right to assign or reassign duties and responsibilities to this job at any time as       business needs dictate   Work Schedule:Monday- Friday 8am-5pm Take the first step to join our team by applying now!  
Job ID
48321
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
he World’s Brightest Minds Always Innovate    At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big, and we give you everything you need to be the force behind our cures.   This role provides radiation services that are required to minimize risks associated with radioactive material and waste in order to maintain the Radiation Safety Program in compliance with State and Federal regulations.   
Job ID
48403
Department
Environ Health & Safety
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for a motivated Lead Researcher to join the lab of Dr. Russell in the Infectious Diseases Department at St. Jude Children's Research Hospital.   Dr. Russell's lab is interested in identifying molecular mechanisms of infectious diseases caused by emerging influenza viruses and paramyxoviruses, negative-strand RNA virus replication and pathogenesis, and studying viral envelope glycoproteins as targets for novel vaccines and drugs.   This is an opportunity to incorporate disciplines from structural biology to studying infectious diseases in animals, better understand how a virus gains pandemic potential in humans, and be on the forefront of improving vaccines.     Experience in viral pathogenesis and working on animal models is preferred. Candidates with good communication and organizational skills, are encouraged to apply. 
Job ID
48474
Department
Infectious Diseases
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a motivated scientist for assay development with special emphasis on flow cytometry and molecular diagnostic laboratory skills. In this role you will provide technical support for global development projects, including flow cytometry panel design, implementation and cross-validation experiments. The selected candidate will be able to develop adapted standard operating procedures for limited resource pathology labs. Experience with molecular diagnostics, including tissue storage, DNA/RNA extraction, library creation preferred. The successful candidate would also be able to provide assistance on small “proof of concept” projects to help decrease major diagnostic discrepancies, increase quality of FFPE samples, and develop low cost tools to aid in diagnosis. Travel required. Foreign language skills preferred. 
Job ID
48660
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
St Jude Children’s Research Hospital launched a major new strategic initiative in human stem cell research.  At the foundation of this initiative was the establishment of a new  human stem cell shared resource called the Center for Modeling Pediatric Disease (CMPD) where human stem cells will be produced and differentiated to improve treatment for catastrophic diseases of childhood. A custom built robotic platform will allow the CMPD to reprogram primary cells and perform differentiation assays at a scale that that is unprecedented.  The CMPD is led by Sunita D’Souza and her energetic, talented, multi-disciplinary team who are dedicated to support the research endeavors of the faculty at St. Jude.   The Researcher in the CMPD will lead all stem cell differentiation studies enabling world-renowned investigators to answer their scientific questions.  This will include development and optimization of new stem cell differentiation procedures and implementation of those procedures at scale for high-throughput drug screening and high-content image based screening efforts. The successful applicant will be responsible for managing all aspects of stem cell differentiation and collaborating with faculty and staff on exciting and innovative research projects. Daily responsibilities include working with the director and facility staff to develop new stem cell differentiation assays, optimize and validate existing assays and perform stem cell differentiation for St. Jude investigators. In addition to the leadership role in stem cell differentiation, you are expected to play an integral role in the day to day operations of the laboratory, consulting with researchers to formulate optimal workflows and experimental priorities. The researcher also designs one-on-one training or education sessions to guide best practices and support productive collaborations across the institution.  You will oversee all work performed, and you are expected to maintain extensive knowledge and expertise in current and emerging stem cell differentiation techniques and the associated protocols. This is a dynamic laboratory environment where you will work with researchers involved in innovative basic and translational research for the fulfillment of our mission: Finding Cures. Saving Children.  
Job ID
46355
Department
Ctr for Modelling Ped Disease
Company
St. Jude Children's Research Hospital
Type
Full Time
There is a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list.  At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve.  There is a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases.  The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers. Job Summary:The Lead Researcher performs a variety of moderately complex research tasks determined by the field and scope of the particular research project/study.  Performs tasks related to the research project independently, but within broad guidelines and subject to periodic review by supervisor or other research staff. Work Schedule:Monday- Friday 8am- 5pm Take the first step to join our team by applying now! 
Job ID
48348
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases.  At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.    St Jude Children’s Research Hospital is committed to investing in and implementing cutting-edge imaging technologies to support basic scientific and translational research.  An integral part of this infrastructure has been the establishment of our Center for In Vivo Imaging and Therapeutics (CIVIT) a dynamic imaging facility that is home to some of the latest technologies including high-resolution ultrasound, bioluminescence and intravital microscopy.  The recent completion of the Inspiration 4 Advanced Research Center provided the opportunity to take bold steps to dramatically enhance our capabilities in preclinical diagnostic imaging through significant investment in high-field MRI and PET including two 9.4T MRI units supported by cryo-coil technology and spectroscopy tools, a PET insert allowing for simultaneous PET and MRI acquisitions and a state-of-the-art PET-CT system.  The availability of cutting-edge ancillary equipment supporting all platforms and an energetic, talented and multi-disciplinary staff ensures that the facility expertly supports the research endeavors of the faculty at St. Jude.   The Director of CIVIT is deeply involved in a wide array of basic science and translational research projects, assisting world-renowned investigators in answering their scientific questions as well as pioneering new applications and technology development to keep the facility state-of-the-art.  The CIVIT comprises the Surgery & Imaging and Preclinical Diagnostic Imaging teams, each managed by an experienced section lead.  The successful applicant will employ and maintain effective communication with investigators and work closely with their team towards optimum planning, scheduling, training for, and implementation of imaging experiments.   This is a dynamic laboratory environment where you will work with researchers involved in innovative basic and translational research for the fulfillment of our mission: Finding Cures. Saving Children.  
Job ID
48458
Department
Ctr for InVivo Imag & Therap
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children’s Research Hospital is seeking a highly motivated candidate to join the Department of Structural Biology as a Lead Researcher to drive a range of initiatives in the Blanchard laboratory.   The successful candidate will enable a complementary array of quantitative biophysical methods to explore clinically important biological systems. Our highly interdisciplinary, collaborative, mission-driven environment requires a creative team-oriented individual with strong leadership skills, who would ensure quality operations and our vision to successfully pursue scientific advances.     Experience with molecular biology, biochemistry and quantitative biophysical techniques is essential. In this role you will be using protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Expert ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing is critical, as well as passion to learn and navigate new research fields.
Job ID
48591
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children’s Research Hospital is one of the world's premier research and treatment centers for pediatric cancer and childhood diseases. It has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and was one of The Scientist’s top 10 “Best Places to Work in Academia” for 7 consecutive years.   The Department of Radiation Oncology at St. Jude is seeking a creative and highly motivated Medical Imaging Scientist who shares our passion for advancing pediatric cancer treatments to join our research team. Under the supervision and guidance of the principal investigator (faculty member), your role will focus on maximizing the therapeutic ratio in proton therapy through novel analysis and modeling of imaging, radiation dose and clinical outcome data. Your discoveries can directly impact pediatric cancer patients treated at St. Jude and the world.   The main areas of our imaging research include improving proton therapy accuracy, developing adaptive proton therapy, and assessing/predicting tumor and normal tissue response to radiation therapy in clinical trials. You will have access to our state-of-the-art imaging technology, which includes two MRI machines, a PET/CT and Spectral CT, all dedicated solely to our department.
Job ID
43761
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases. At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. St. Jude Children Research Hospital ensures that scientific progress is never halted from a lack of resources. We are building on that success with a comprehensive strategy to expand our mission, including our reach around the world.    St. Jude Children’s Research Hospital is launching a major new strategic initiative in spatial transcriptomics to support basic scientific and translational research.  At the foundation of this initiative is the establishment of a new spatial transcriptomics shared resource that will be home to some of the most cutting edge technologies in the field. State-of-the art ancillary equipment supporting all platforms and an energetic, talented, multi-disciplinary team to staff the facility synergize together to support the research endeavors of the faculty at St. Jude.   The Director of the Spatial Transcriptomics Shared Resource will take the lead in hiring and training their staff, identifying technologies to introduce to the facility and designing the research space. Once the new facility has been opened, the Director will become deeply involved in a wide array of basic science and translational research projects, enabling world-renowned investigators to answer their scientific questions.  The successful applicant will be responsible for managing the Spatial Transcriptomics Shared Resource and collaborating with faculty and staff on exciting and innovative research projects. Daily responsibilities include managing the accurate and efficient performance of facility staff, including quality control, and instrument maintenance. In addition to the management responsibilities, you are expected to play an integral role in the day to day operations of the laboratory, consulting with researchers to formulate optimal workflows covering acquisition in line with data processing, and data analysis. The Director also designs one-on-one training or education sessions to guide best practices and support productive collaborations across the institution. You will oversee all work performed, and you are expected to maintain extensive knowledge and expertise in current and emerging spatial transcriptomics techniques and the associated protocols. This is a dynamic laboratory environment where you will work with researchers involved in innovative basic and translational research for the fulfillment of our mission: Finding Cures. Saving Children.    
Job ID
46545
Department
Spatial Transcriptomics Core
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see firsthand, how your science translates into survival for the children we serve. We are seeking a self-motivated and detail-oriented Scientist to join the laboratory of Dr. Ellison, in the Department of Pathology. Dr. Ellison's lab is interested in exploring the clinical and molecular features associated with pediatric brain tumors, particularly ependymoma.   Candidates should be able to perform and coordinate a wide range of laboratory research procedures and conduct a spectrum of complex support tasks and projects determined by our current research. Your duties will include molecular, cellular, and biochemical analyses using methods such as ChIP-Seq, ATAC-Seq, Single Cell-Seq, and processing tissue for translational studies. You will also manage murine colonies and perform cranial implants. Candidates should be able to communicate effectively, work independently, and present scientific findings.     Preferred Skills Experience with ChiP-Seq, ATAC-Seq, Single Cell-Seq, DNA and RNA extractions, and immunohistochemistry is preferred. Experience with animal husbandry, breeding, colony management and genotyping is preferred. Candidates with good communication and organizational skills are encouraged to apply.
Job ID
47906
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
Protein Technologies Center (PTC) is seeking an experienced Surface plasmon resonance (SPR) Scientist who will characterize molecular interactions using SPR and other methods to support Structural biology projects.   The candidate is responsible for the operation and maintenance of the SPR instruments; and should independently plan, optimize and execute experiments to measure the kinetic and equilibrium binding constants. S/he will explore, develop, and apply new methods and technologies to understand the protein-ligand interactions. The candidate will be interacting closely with other scientists and investigators and participating in collaborative research towards understanding the cell functionality and mechanism of disease; should also be willing to train postdocs and other staff members on the instruments.   Preferred skills and experience - Hands-on experience using Biacore (T200 or S200 or 8K) and/or other biosensors and techniques to analyze a variety of molecular interactions. - Broad knowledge and understanding of the macromolecular structure, protein-ligand interactions, and biophysical properties. - Demonstrated ability to tackle multiple projects 
Job ID
48298
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
A Senior Researcher position is currently available in the Pharmacotyping Resource, located within the Pharmacy and Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, TN.   The mission of the Pharmacotyping Resource is to leverage new drug screening technology to enable collaborative pharmacogenomics research that will translate into improved cancer treatment outcomes.  The resource uses a state-of-the-art fluorescence imaging platform to test drug sensitivity profiles (pharmacotyping) of a variety of pathologic tissues obtained from children with catastrophic diseases, with a focus on pediatric cancer. We seek an accomplished, self-motivated, meticulously organized senior researcher with a strong background in cell culture and microplate assays to work with fluorescence imaging and drug assay development.     Candidates should have experience with cell culture and be able to perform a wide range of laboratory research procedures and conduct complex support tasks and projects determined by our current research. Duties will include molecular and cellular analyses and ex vivo testing of patient tissues using fluorescence imaging methods. The position will involve interaction with other staff scientists, bioinformaticians, and trainees and presentation of scientific findings during regular working group meetings. Candidates should be able to communicate effectively and work both independently and as part of a team.   Preferred Skills: Experience with handling and processing of primary tissues for cell culture, DNA extraction, microplate assays and fluorescence imaging are strongly preferred. Candidates with excellent communication and organizational skills are encouraged to apply.
Job ID
48457
Department
Pharmaceutical Sciences
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking an outstanding and highly motivated Senior Researcher to join the laboratory of Dr. Mitchell Weiss, chair of the Department of Hematology at St. Jude Children’s Research Hospital.   The Weiss lab is particularly interested in non-malignant disorders of the hematopoietic system including β-thalassemia and sickle cell disease. Our research involves defining the mechanisms of gene regulation during hematopoiesis, the functions of non-coding RNAs, and the mechanisms of protein quality control such as autophagy and ubiquitin-mediated proteolysis in red blood cell formation and associated diseases. Moreover, we are developing novel genome editing based strategies to explore new therapies for β-thalassemia and sickle cell disease using Cas9 genome editing, base editing and other technologies.     We care deeply about the success of our lab members. We are also highly supportive of candidates who wish to pursue a PhD in the future.During his career at Harvard, University of Pennsylvania and St. Jude Children’s Research Hospital, Dr. Weiss has trained numerous students and post-doctoral fellows, most of who have gone on to successful careers in academia or industry.   The successful applicant will be experienced and conversant in a range of experimental approaches including mammalian cell cultures, animal experimentation and basic biochemical tools. Proficiency in in vivo [mouse] husbandry and manipulation is strongly preferred but not required.   Please include your CV and a cover letter (no more than 2 pages) If you have questions about the position, please do not hesitate to email Dr. Christakopoulos (gchrista@stjude.org) or Dr. Weiss (mitch.weiss@stjude.org).
Job ID
F1412
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
The McKinnon lab is seeking an experienced and motivated neuroscientist/molecular biologist, who has an interest in understanding the mechanisms of neurological disease.   The general focus of the lab is understanding genome stability mechanisms in the nervous system and how these prevent neurological disease.     The ideal candidate will have a PhD and postdoctoral experience in molecular biology preferably with a focus on neuroscience. They will also have exceptional organizational skills and broad experience in the operations of a research laboratory.
Job ID
48528
Department
Ctr-Ped Neurological Dis Res
Company
St. Jude Children's Research Hospital
Type
Full Time
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior Biochemist/Biophysicist or Cell Biologist/Chemical Biologist to design and implement high throughput screens: - Biochemist/Biophysicist: high throughput direct binding assays to measure compound-target interaction from medium (as secondary assays)- to large-scale (for primary screens) - Cell Biologist/Chemical Biologist: cell-based phenotypic screens, ranging from large-scale automated cytotoxicity screens, medium-scale genetic loss-of-function siRNA screens, to focused high-content imaging-based screens   The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The HTS Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 600K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.
Job ID
44167
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time

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