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We are seeking a highly motivated and creative Lead Bioinformatics Analyst to join the team of Dr. Kim Nichols in the Division of Cancer Predisposition at St. Jude Children's Research Hospital. As a Lead Bioinformatics Analyst your responsibilities will involve running existing genetics pipelines and developing new, faster and more efficient pipelines to support projects in cancer genetics and functional genomics. You will have ample opportunities to engage in research studies focusing on known hereditary forms of childhood cancer and discovery of new causes for familial cancers. You will be highly integrated into many existing and future collaborative projects within and outside of St. Jude which will allow for educational and cross-training opportunities.   You will work closely with research team members to analyze large-scale genomic datasets including WES, WGS, bulk and single cell RNA-seq, Cut&Run and ATAC-seq data, to identify novel cancer predisposing germline variants and interrogate the impacts of these variants on downstream gene function. You will develop, improve, modify, and operate data analysis pipelines, generate and provide analysis results and reports, and perform requested custom analyses.   The Department provides a highly interactive environment with collaborative opportunities, access to high performance computing clusters, a cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from scientists with interests experience in data analysis, data management and delivery of high-quality results. The Division of Cancer Predisposition supports strong teamwork as well as individual and personal growth.   Candidates with a strong background and interest in genetics, cancer biology, and experience with use of genetic approaches to understand disease pathogenesis are highly encouraged to apply for this position. Familiarity with the analysis of large-scale cancer genomic datasets for germline as well as somatic mutations is preferred. This position is located in Memphis, TN, and relocation assistance is available.
Job ID
47904
Department
Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Laboratory of Dr. Jinghui Zhang, Chair of Computational Biology Department, is seeking a highly motivated Sr. Bioinformatics Research Scientist to work on large-scale data mining and integrative analysis of genomic, transcriptomic, and proteomic data aimed at discovery of new therapeutic targets. Candidates with a strong background in bioinformatics and cancer genomics are highly encouraged to apply for this position. Successful candidates will have strong programming skills, critical thinking, experience in analyzing proteomics and transcriptomic data or epigenetic data, and excellent communication skills for data presentation and manuscript preparation.    Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics and Nature Methods. The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management and delivery of high-quality results for highly collaborative projects. This position is located in Memphis, TN, and relocation assistance is available.  
Job ID
44379
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
M. Madan Babu's Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biology is seeking a highly driven, full-time Principal/Senior Bioinformatics Research Scientist to serve as the Web Development and Design lead to support the Kalodimos and Babu Groups on the Blue Sky Initiative "Seeing the Invisible in Protein Kinases." This project is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027). This is a joint project between the Kalodimos Lab and the Babu Group at St Jude.   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.    The ideal candidate will be an expert in UX/UI design and back-end development of web applications to help scientists visualize, analyze and understand high-dimensional biological data. You will have a strong background in computer science, web development, bioinformatics, or computational biology and truly exceptional skills in designing visualizations to render complex, multi-dimensional biological data interpretable and understandable. You should be able to present or provide links to a strong work portfolio that demonstrates your expertise in designing, building, and deploying insightful web-based applications. You will be a team player and will work as part of an interdisciplinary team of 40 scientists including biochemists, NMR spectroscopists, data scientists and bioinformaticians. Exceptional communication (written and verbal) and critical thinking skills are a must.     When submitting your application, please include your CV and a cover letter, which includes information or a link to a portfolio of past projects.   Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.   The Department of Structural Biology is building one of the world’s most comprehensive research center for defining molecular structures to understand health and disease at the molecular level. The Department is home to multiple Technology Core Centers (Cryo-EM and Tomography, X-ray, NMR, Single-Molecule Imaging, and Protein Technologies) ready to characterize Data Driven Discoveries.
Job ID
44690
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
M. Madan Babu's Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biology is seeking a highly driven, full-time Principal Bioinformatics Research Scientist to serve as a Database Engineer to support the Kalodimos and Babu Groups on the Blue Sky Initiative "Seeing the Invisible in Protein Kinases." This project is supported by $35 million in institutional funding (more information in the  St. Jude Strategic Plan 2022–2027 (pp 62-63). This is a joint project between the Kalodimos Lab and the Babu Group at St Jude.   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.    This position is for a senior-level database engineer who will employ a variety of languages and tools to develop, construct, test and maintain data pipelines to organize multimodal biological information, and work with data scientists and visualization specialists to make biological discoveries and reveal fundamental principles of biological systems. The ideal candidate will have strong experience working in data warehouse environments and developing data marts to help scientists query, visualize and understand high-dimensional biological data.  This role requires a strong background in computer science, data architecture and database management. You will work with an interdisciplinary team of 40 scientists including biochemists, spectroscopists, data scientists and bioinformaticians; exceptional communication (written and verbal), training experience and critical thinking skills are a must. When submitting your application, please include your CVand a cover letter. St Jude offers a well-defined career ladderwith potential for growth and advancement. Industry-competitive salaries are based on your degree and years of experience.   Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.   The Department of Structural Biology is building one of the world’s most comprehensive research center for defining molecular structures to understand health and disease at the molecular level. The Department is home to multiple Technology Core Centers (Cryo-EM and Tomography, X-ray, NMR, Single-Molecule Imaging, and Protein Technologies) ready to characterize Data Driven Discoveries.   St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Kalodimos and Babu Groups strive to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
Job ID
44976
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The department of Pathology is seeking a highly motivated Bioinformatics Research Scientist to lead projects to dissect the underlying mechanisms for an uncommon but clinically important pediatric brain tumor called ependymoma. Dealing with large numbers of genomic and epigenomic datasets, including DNA methylation profiling, gene expression profiling and ChipSeq, you will be working with scientists from the lab of Dr. David Ellison. Candidates with a strong background in bioinformatics, computational biology, and cancer genomics are highly encouraged to apply for this position. You will not only be manipulating the data, but also visualizing data for presentations and publications. This role provides an exciting opportunity to solve challenging, but highly relevant, scientific questions with new methodologies such as ATAC-Seq, whole-genome bi-sulfite sequencing and single cell RNA-seq.   In this role, you will become an expert in both genomics and functional genomics by working in a highly collaborative environment. Specific responsibilities may involve developing and evaluating analytic tools and, through collaborative initiatives, machine-learning approaches for genomic analysis, communicating with our partners and users, project management, and manuscript preparation. You will work closely with members of our Center for Applied Bioinformatics, giving you access to high performance computing clusters, a cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentoring from scientists with deep experience in data analysis, data management and delivery of high-quality results. Take the first step to join our team by applying now!
Job ID
F1308
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
A Bioinformatics Research Scientist position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to perform computational analysis for understanding 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will develop innovative methods and perform analysis to determine haplotype phasing using chromatin contact maps and for investigating heterogeneity in 3D genome architecture at the level of single cell.   The successful candidate will have good training in human genetics and bioinformatics analysis. Additional training and experience in epigenetics and cancer biology are preferable. The candidate is expected to be a critical thinker, a quick learner for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidate must have a doctoral degree (PhD or MD), an excellent publication record, and great communication skills
Job ID
46483
Department
Collaborative Research Program
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we can advance cures for catastrophic pediatric diseases by supporting the brightest scientific minds. That is why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. This position is an outstanding opportunity for a highly motivated candidate to join as a Bioinformatics Specialist in Dr. Junmin Peng laboratory. Our laboratory uses multiple -omics and computational tools to study the full scope of disease. Much of our effort centers on mass spectrometry-based approaches to explore DNA, RNA, proteins, and metabolites. We use these technologies to study cancer, Alzheimer’s disease, and immune responses. Our work impacts everything from discovery of pathogenesis to the development of new treatments.
Job ID
47788
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Epidemiology and Cancer Control at St. Jude Children’s Research Hospital is seeking a highly qualified and motivated Bioinformatics Analyst with a demonstrated expertise in computational and statistical genomics to study the genetic and biological mechanisms underlying long-term toxicities of cancer treatments among survivors of childhood cancer.   The successful candidate will have a strong background in statistical genetics/genomics, biostatistics, computational genomics, bioinformatics, or a related quantitative field, and strong programming skills, and should be excited to contribute to advancing the science and pharmacogenomics of treatment-related late effects in childhood cancer survivors. Research projects will involve creating pipelines and analyzing large-scale omics data including, but not limited to, whole genome and whole exome sequencing, RNA-seq, ATAC-seq, proteomics and metabolomics, in relation to the clinical phenotypes. Strong research experience in genome-wide association studies (GWAS) of common and rare variants (both NGS and chip-based genotype) data and eQTL mapping is required. Proficiency in statistical genetics/genomics software including PLINK, GATK, matrixeQTL, and at least one of more programming languages such as R, Python, Perl, Java, or C++ under Linux/Unix environment is required. Familiarity with large genetic databases such as the UK Biobank, 1000 Genomes Project, gnomAD and others is desired.    The department provides a highly interactive environment with collaborative opportunities, access to high performance computing clusters, a cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from scientists with interests experience in data analysis, data management and delivery of high-quality results. The Department of Epidemiology and Cancer Control supports strong teamwork as well as individual and personal growth.    Please include a cover letter including responses to the required skills/qualifications.  
Job ID
46451
Department
Epidemiology & Cancer Control
Company
St. Jude Children's Research Hospital
Type
Full Time
The Geeleher Lab is seeking a Bioinformatics Research Scientist to work on exciting projects related to cancer genomics, pharmacogenomics, and drug repurposing in the St. Jude Department of Computational Biology. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources, a collaborative environment, and access to extensive, unique cancer genomics datasets from large-scale research initiatives.   Positions are available in these broad research areas: - Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents. Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics. You will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications. (Projects funded by our NCI R01 award). - Developing computational methods for single-cell RNA-seq and spatial transcriptomics data. Recent advances have allowed the measurement of genome-wide gene expression directly within tissue sections, using a set of technologies referred to as spatial transcriptomics. These tools allow us to dissect tumor heterogeneity in unprecedented detail and will allow us to study the determinants of drug response at a resolution not previously possible. You will develop new computational and statistical methodologies for analyzing and interpreting these data and develop approaches to integrate spatial transcriptomics with matched single-cell RNA-seq data. You will utilize both Visium and MERFISH data, with a primary focus on neuroblastoma. This work will aim to improve our understanding of tumor heterogeneity and yield computational approaches applicable to a broad variety of complex traits and diseases. (Projects funded by our NIGMS R35 award) The Geeleher Lab is recognized for developing innovative computational approaches and has led drug re-purposing efforts, spearheaded publications in Nature, Genome Research, Genome Biology, Journal of the National Cancer Institute (JNCI) and Bioinformatics in the last five years, and is funded by the NIH. St. Jude offers an exceptional research environment, including state-of-the-art high-performance computing facilities, robust analytical pipelines, the latest wet-lab technology, access to outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science. The Department of Computational Biology is highly interactive with collaborative opportunities across basic and clinical departments and mentorship from faculty-level scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects
Job ID
46447
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Yang Lab  is seeking a Bioinformatics Analyst to work on exciting projects related to leukemia genomics and pharmacogenomics in the St. Jude Department of Pharmacy and Pharmaceutical Sciences. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources, a collaborative environment, and access to extensive, unique cancer genomics datasets from large-scale research initiatives.   In a collaboration with Dr. Jiyang Yu’s group in Department of Computational Biology, we are interested in developing and implementing novel computational biology tools, including NetBID (Gocho et al., Nature Cancer 2021), by integrating multi-omics data at both bulk and single-cell levels, to dissect the signaling circuitry related to leukemia biology and drug response. Under the supervision of Bioinformatics Research Scientists, the candidate will work along with pharmacologists, cancer biologists, and clinicians to analyze large-scale genomic datasets and to identify molecular drivers for a variety of leukemia phenotypes, to develop novel therapy for children with this cancer. The successful applicant will work in a dynamic and productive environment with exposure to research from basic biology, preclinical drug evaluation, to clinical trial development.   St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development. In this position, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the infrastructure in our lab with the goal of providing flexibility and freedom in exploring new research directions.
Job ID
47897
Department
Pharmaceutical Sciences
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Computational Biology is seeking a highly motivated Bioinformatician to develop and apply computational and systems biology approaches to dissect the molecular circuits that drive tumorigenesis, tumor immune-escape and drug resistance, and identifying novel immunotherapy targets, biomarkers and combination therapies (particularly with immunotherapy) for the treatment of pediatric cancers. This analyst/scientist will analyze and integrate high-throughput omics data, at bulk and single-cell levels, including transcriptomic, genomic, epigenomic, functional genomic, chemical genomic and proteomic data to model context-specific cellular/molecular networks and to identify actionable targets, biomarkers or compounds that could be translated into clinic for the development of precision medicine in pediatric cancer. The scientist will report to Dr. Jiyang Yu and will work closely with our collaborators in the departments of Immunology and Oncology for experiment design and data generation, and with our pipeline and visualization teams to explore novel analysis approaches for single-cell RNA-Seq, NGS-based RNAi/CRISPR screening, immune-profiling and proteomics data for molecular network inference and target identification.   Candidates with a strong interest in cancer immunotherapy, cancer precision medicine and expertise in oncology, immunology, computational biology, bioinformatics are encouraged to apply. The successful candidate will also have an opportunity to participate in research projects involved in the analysis of the cancer genome, epigenome, transcriptome or proteome. Experience with omics data analysis using R or Python and familiarity with linux/unix is required. Experience and knowledge in immunology and/or immuno-oncology is highly desirable. Expertise in systems biology, network biology, parallel computing, web development, visualization and databases is also highly desirable.   The Yu Lab provides a highly interactive environment with projects involving basic and clinical research collaborators, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.    
Job ID
44476
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Transcriptomics Group from the Center for Applied Bioinformatics at St. Jude Children's Research Hospital is looking for a highly motivated and creative Bioinformatics Research Scientist or Lead Bioinformatics Analyst to develop and apply innovative analytical approaches to understand the underlying mechanisms that drive pediatric cancers and other human diseases with bulk, single cell and spatial expression data. The Scientist or Analyst will contribute ideas to automate and improve existing analysis methods, assist in preparing and submitting manuscripts for publication and assist with establishing and documenting protocols or best practices for common research tasks.  Specific responsibilities may involve developing and evaluating analytic tools of sequencing data, data visualization, and statistical approaches for functional genomics analysis. Candidates with a strong background in bioinformatics, genomics, cancer genomics, mouse genetics or related fields and knowledge in leukemia and immunogenomics are highly encouraged to apply for this position. Excellent communication skills are essential.   The Center provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. The members of this Center have the opportunities to publish high profile papers with prominent authorship depending on the intellectual contribution. This position is located in Memphis, TN, and relocation assistance is available.  
Job ID
46522
Department
Center for Applied Bioinformatics
Company
St. Jude Children's Research Hospital
Type
Full Time
The Mefford Lab in the Center for Pediatric Neurological Disease Research at St. Jude Children’s Research Hospital uses genome-wide approaches to identify genetic, genomic, and epigenetic causes of human disease including epilepsy, and related pediatric neurodevelopmental disorders. The major focus of our current work is to identify causes of pediatric epilepsy by employing state-of-the-art technologies including whole-exome sequencing, targeted gene panel sequencing, RNA-seq in patient-derived cells, genome-wide methylation arrays. The Mefford lab has discovered numerous new epilepsy genes and copy number variants responsible for pediatric epilepsy, each of which causes a range of clinical features.    The Lead Bioinformatics Analyst will take a prominent role in our research and collaborations to analyze multiple types of genomics data: exome and genome sequence, bulk RNA-seq, single-cell/nuclei RNA-seq, methylation, SNP array, and others to identify variants associated with human genetic conditions and understand their underlying mechanisms. The ideal candidate will be capable of self-directed research within broader goals set by the group, have previous experience with next-generation sequence data analysis highly desirable, knowledge of statistical/mathematical packages such as R.   
Job ID
45000
Department
Ctr-Ped Neurological Dis Res
Company
St. Jude Children's Research Hospital
Type
Full Time
M. Madan Babu's Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biologyis seeking a highly driven, full-time human geneticist. This post will be part of a newly established Centre for Adipocyte Signaling (ADIPOSIGN) funded by a major grant from the Novo Nordisk Foundation. This position is available immediately with four years of funding. ADIPOSIGN is run by four partners with highly complementary expertise in the fields of adipocyte biology, transcriptional regulation, signal transduction, physiology, and computational systems biology:   Susanne Mandrup, Prof., Dept. Biochemistry and Molecular Biology, SDU, DK Jan-Wilhelm Kornfeld, Prof., Dept. Biochemistry and Molecular Biology, SDU, DK Madan Babu, Member, Dept. of Structural Biology SJCRH, USA Zach Gerhart-Hines, Assoc. Prof., NNF Center for Basic Metabolic Research, University of Copenhagen, DK   The ideal candidate may have extensive expertise and a proven track record in statistical genetics, population genetics, computational analysis of human genetics and large-scale phenotype data and interpreting genome variation data (coding and non-coding variant effects). Your primary role as a computational human geneticist will be to identify, develop, implement and use computational genetics methods to integrate, mine, visualize and analyze multiple large-scale molecular omics and natural variation datasets for hypothesis generation, polygenic risk score calculation, and creation of molecular network models of obesity. You will develop computational pipelines and machine learning approaches to analyse genome sequences in order to quantify obesity risk and predict its effects. When submitting your application, please include a cover letter.   This position requires relocation to Memphis, TN. When possible, it will involve travel for collaborative purposes to Denmark. You will be working in a highly dynamic and collaborative environment, and will be expected to communicate complex informatics principles, methods, analyses and results to scientists from diverse backgrounds in the consortium.Excellent interpersonal and communication skills are a must, as you will interact directly with both Computational Biologists and Experimentalists in a highly interdisciplinary environment.   Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.   Preferred skills and experience: - Experience with GWAS data analysis, QTL, eQTL analysis, and other methods of linking genotype and epigenetics information to phenotype - Experience with development, implementation and application of Polygenic Risk Score estimation for phenotypes - Experience with diverse statistical data analysis approaches (Bayesian and non-Bayesian statistical methods) - Interest and expertise in adipocyte biology, human physiology, or other areas relevant to the study of obesity - Interest or expertise in GPCR signalling, transcription, metabolic pathways, and/or nuclear receptors is desirable - Experience with writing reports, developing web interfaces for data analysis and/or data dissemination. - Experience with developing and maintaining databases (ideally graph databases) - Experience with novel data visualisation methods
Job ID
45020
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Performs data analysis, data visualization, statistical analysis, experimental design, database development, mathematical modeling, and novel method development. Provides bioinformatics analysis for investigators and communicates analytical process and results. Assists in preparing and submitting manuscripts for publication. Contributes ideas to automate or improve existing analysis methods, and innovative algorithm development. Assists with establishing and documenting protocols or best practices for common research tasks. Ensures that efficient and prompt help is provided to SJCRH PIs and other investigators.
Job ID
44919
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Madan Babu's Group and the Core Center for Data Driven Discovery in the Department of Structural Biology are looking for an exceptional candidate to work on the broad area of cancer genetics and genomics by taking an integrative approach utilizing various publicly available omics and molecular data sets (including population genomics data). This position is supported by an Alex’s Lemonade Stand Crazy 8 Initiative grant. Charles Mullighan, MD, MBBS, leads the project, which has assembled researchers from five departments at St Jude to develop molecular glue therapeutics to target acute leukemia or medulloblastoma cancers that are untreatable with traditional drugs. The candidate will conduct research investigations on key cellular regulatory pathways and their dysfunction in pediatric and adult cancers with an overarching aim of identifying key therapeutic targets for further experimental studies in the Group and the Center, to ultimately deliver new targets to the St. Jude translational pipeline. This position is for an experienced Bioinformatics Analyst with a strong background in computer science, database management, and prior experience using and analyzing large data sets from Cancer mutation databases. The ideal candidate will be able to identify, develop, and use computational biology methods to integrate, mine, visualize, and analyze multiple large-scale omics datasets and biomolecular network data (transcriptional, metabolic, signaling networks) for hypothesis generation on multiple projects. The candidate will have strong experience working in structured data environments, importing and managing datasets from public sources. The candidate will support end-users by developing queries and delivering initial analyses to help them visualize and understand high-dimensional biological data. The key cellular pathways that are of immediate interest to the group are GPCR signaling pathways, gene regulatory programs and post-translational regulation. The candidate will have an excellent opportunity to learn to perform integrative data analyses traversing different scales of molecular detail from atomic details to cellular networks. The candidate will have a vibrant working environment in our Group, which consists of Computational Biologists and Experimentalists with expertise in domains ranging from GPCR signaling, gene regulation, disordered proteins, cancer biology and evolution.  The ideal candidate will have - Full proficiency in R and/or Python and development of statistical data analysis methods - Demonstrated proficiency in MySQL database development and administration - Proven track record in using and analyzing large data sets from Cancer and other mutation databases such as cBioPortal, DepMap, TCGA, TCGA-MC3, COSMIC, PeCan, ClinVar, dbSNP and UK Biobank - Expertise with common sequence data formats such as GFF, VCF, FASTA, FASTQ and BAM, and ontology formats such as OWL, OBO and SKOS - Excellent written, oral, and interpersonal communication skills to interact with data scientists and experimentalists Consistently ranked Top 10 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is the only NCI-designated Comprehensive Cancer Center devoted solely to children, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, will be the new home of the Babu Group and the Center of Excellence for Data Driven Discovery. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology departments, and tremendous support from the Center for Applied Bioinformatics. St Jude offers a well-defined career ladder with potential for growth and advancement. Industry-competitive salaries are based on your degree and years of experience.
Job ID
46617
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Chi Lab is seeking a Systems Immunology Specialist to work on exciting projects related to immune signaling and metabolism in the St. Jude Deparment of Immunology. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources, a collaborative environment, and access to extensive, unique cancer genomics datasets from large-scale research initiatives. In this role you will assist with the curation, integration, and analysis of immunology, oncology, and cancer immunology data using methods from computational and systems biology. She/he will assist in the development, implementation, and maintenance of computational biology and immunology databases. Experience in R programming language preferred.  
Job ID
44412
Department
Immunology
Company
St. Jude Children's Research Hospital
Type
Full Time
M. Madan Babu's Group and the Center for Data-Driven Discovery in the Department of Structural Biology is seeking a highly driven, full-time Machine Learning Research Scientist support the Kalodimos and Babu Groups on the Blue Sky Initiative "Seeing the Invisible in Protein Kinases." This project is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027, pp 62–63). This is a joint project between the Kalodimos Lab and the Babu Group at St Jude.   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature, 2020), to systematically characterize the conformational landscape of the human kinome.   This position is for an experienced Machine Learning Scientist who will employ a variety of data-driven techniques to develop, construct and test machine learning systems aimed at predicting drug binding to human kinases. The ideal candidate will have strong experience working with and developing state of the art Machine Learning methods for structure-based drug design and protein binding predictions with significant experience working on protein kinases. This role requires a strong background in machine learning, computational chemistry, computer science, statistical analysis and data integration. You will work with an interdisciplinary team of 40 scientists including biochemists, spectroscopists, data scientists and bioinformaticians; exceptional communication (written and verbal), training experience and critical thinking skills are a must. When submitting your application, please include your CV and a cover letter.   The Group believes strongly in providing excellent scope for career advancement to the candidate to develop themselves as a future leader in the field. There will be strong support and encouragement for developing mentoring abilities, "outside the box" scientific ideas and acquiring tangential scientific/technical skills. St Jude offers a well-defined career ladder with potential for growth and advancement. Salaries are highly competitive with Industry, and scale with your degree and years of experience.   St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Babu Group strives to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.    
Job ID
47741
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time

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