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We are seeking outstanding, highly motivated candidates for scientist roles in the new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.   You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.   You will have the opportunity to learn about and support new exciting projects such as: - Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin. - Process development and IND-enabling studies (Pharm/Tox) Apply today! A cover letter is highly recommended.   Please include a cover letter in your application addressed to Dr. Jonathan Yen.    
Job ID
F1180
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.   This is an exciting opportunity for a self-motivated scientist to join the Immunology Department at SJCRH in the laboratory of Dr. Thirumala Devi-Kanneganti. Our laboratory extensively employs murine models to understand how the innate immune system recognizes and responds to pathogens and how genetic mutations in innate immunity affect the development of infectious, inflammatory, and autoimmune diseases in humans.  
Job ID
F1196
Department
Immunology
Company
St. Jude Children's Research Hospital
We are seeking a highly motivated and creative bioinformatics research analyst to join the team of Dr. Kim Nichols in the Division of Cancer Predispositon at St. Jude Children's Research Hospital. The bioinformatics analyst will develop and apply innovative analytical approaches in the area of cancer genetics and functional genomics and have the unique opportunity to help carry out research studies that focus on known hereditary forms of childhood cancer and discovery of new causes for familial cancers.   You will work closely with research team members to analyze data such as WES, WGS, bulk and single cell RNA seq,Cut&Run seq and ATAC seq data, to identify novel cancer predisposition genes and interrogate their biological function. You will develop, improve, modify, and operate data analysis pipelines, generate and provide analysis results and reports, and perform requested custom analyses.   The department provides a highly interactive environment with collaborative opportunities, access to high performance computing clusters, a cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from scientists with interests experience in data analysis, data management and delivery of high-quality results. The Division of Cancer Predisposition supports strong teamwork as well as individual and personal growth.    Candidates with a strong background and interest in genetics, cancer biology, hematopoiesis, and experience with use of genetic approaches to understand disease pathogenesis are highly encouraged to apply for this position. Familiarity with statistical genetics/genomics software including MERLIN, PLINK, GATK, EdgeR, samtools is preferred. This position is a forecasted position located in Memphis, TN, and relocation assistance is available.    
Job ID
44054
Department
Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior cell and molecular biologist/chemical biologist to design and implement a variety of cell-based phenotypic screens, ranging from large-scale automated cytotoxicity screens, medium-scale genetic loss-of-function siRNA screens, to focused high-content imaging-based screens. The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The HTS Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 600K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.  
Job ID
44167
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time
The laboratory of Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a Scientist, starting in November 2021, to define and improve genome editing strategies for treatment of sickle cell disease. The ideal candidate will have experience with genome editing technologies, human hematopoietic stem cells, or high-throughput genomics.   You will have the opportunity to work with a group of talented interdisciplinary team of scientists to develop autologous cell therapies with the goal of treating patients here at St. Jude Children’s research hospital and worldwide. Examples of exciting projects include: - Optimizing pre-clinical CRISPR-Cas gene editing strategies for treating sickle cell disease by induction of fetal hemoglobin as a replacement for adult sickle hemoglobin. - Developing strong pre-clinical data to support advancing potentially curative, autologous cell therapy approaches to treating SCD. - Protein engineering of CRISPR-Cas genome editors with improved activity, targeting range, or specificities. - Define the safety or genome-wide activities of therapeutic genome editors. In this position, you will gain extensive experience and training in genome editing, sickle cell disease, high-throughput genomics, and characterization of human hematopoietic stem cells. We strongly support the career development of lab members through opportunities to publish in high-impact journals and present work at academic conferences. For more information about our lab and recent publications visit: www.tsailab.us   *Please include a cover letter with your application that will be reviewed directly by Dr. Tsai.  
Job ID
F1226
Department
Hematology
Company
St. Jude Children's Research Hospital
The Center for Pediatric Neurological Disease Research (CPNDR) is in search for a Research Operations Manager to manage the core facilities and coordinate the overall daily lab operations.   The successful candidate will have education and knowledge in neuroscience, have initiative, and the ability to work independently. The successful candidate will be expected to run and maintain a state-of-the-art histology and tissue processing core that will serve members of the CPNDR, DNB and associated St. Jude neuroscience investigators. The successful candidate will provide guidance for broad histology and tissue processing methodologies and will serve and help build collaborative relationships across the St Jude neuroscience community. Operational priorities will include ensuring the core is performing at a high level of service and operations and also helping promote the CPNDR to neuroscience Investigators at St. Jude Children's Research Hospital.    
Job ID
44326
Department
Center for Pediatric Neurological Disease Research
Company
St. Jude Children's Research Hospital
Type
Full Time
The department of Computational Biology is seeking a highly motivated Sr. Bioinformatics Research Scientist to serve as the scientific lead for St. Jude Cloud, a cloud-based ecosystem for data sharing, cloud-computing and dynamic visualization of the world’s largest pediatric cancer genomic data set. The candidate will be a part of an interdisciplinary team consisting of scientists and engineers from St. Jude and our external partners at DNAnexus and Microsoft. Specific responsibilities include providing scientific guidance for the engineering team, organizing pilot studies to evaluate collaborative research initiatives, developing prototypes of workflow and designing new concepts for data visualization, performing curation on data releases, and participating in presentation and training of St. Jude Cloud platform to the biomedical community.      Candidates with a strong background in bioinformatics, computational biology, and cancer genomics are highly encouraged to apply for this position. Successful candidates shall have well-established track record in cancer genomic research, in-depth experience in data analysis, excellent critical thinking and communication skills, as the St. Jude Cloud project is an institutional strategic initiative and this position will frequently interact with senior scientists from departments across the institution, as well as external partners and collaborators.   Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics and Nature Methods. The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management and delivery of high-quality results for highly collaborative projects. This position is located in Memphis, TN, and relocation assistance is available.    
Job ID
44379
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Geeleher Lab is seeking a Bioinformatics Research Scientist to work on exciting projects related to cancer genomics, pharmacogenomics, and drug repurposing in the St. Jude Department of Computational Biology. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources, a collaborative environment, and access to extensive, unique cancer genomics datasets from large-scale research initiatives.   Positions are available in these broad research areas: - Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents. Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics. You will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications. (Projects funded by our NCI R01 award). - Developing computational methods for single-cell RNA-seq and spatial transcriptomics data. Recent advances have allowed the measurement of genome-wide gene expression directly within tissue sections, using a set of technologies referred to as spatial transcriptomics. These tools allow us to dissect tumor heterogeneity in unprecedented detail and will allow us to study the determinants of drug response at a resolution not previously possible. You will develop new computational and statistical methodologies for analyzing and interpreting these data and develop approaches to integrate spatial transcriptomics with matched single-cell RNA-seq data. You will utilize both Visium and MERFISH data, with a primary focus on neuroblastoma. This work will aim to improve our understanding of tumor heterogeneity and yield computational approaches applicable to a broad variety of complex traits and diseases. (Projects funded by our NIGMS R35 award) The Geeleher Lab is recognized for developing innovative computational approaches and has led drug re-purposing efforts, spearheaded publications in Nature, Genome Research, Genome Biology, Journal of the National Cancer Institute (JNCI) and Bioinformatics in the last five years, and is funded by the NIH. St. Jude offers an exceptional research environment, including state-of-the-art high-performance computing facilities, robust analytical pipelines, the latest wet-lab technology, access to outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science. The Department of Computational Biology is highly interactive with collaborative opportunities across basic and clinical departments and mentorship from faculty-level scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects
Job ID
44456
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Computational Biology is seeking a highly motivated Bioinformatician to develop and apply computational and systems biology approaches to dissect the molecular circuits that drive tumorigenesis, tumor immune-escape and drug resistance, and identifying novel immunotherapy targets, biomarkers and combination therapies (particularly with immunotherapy) for the treatment of pediatric cancers. This analyst/scientist will analyze and integrate high-throughput omics data, at bulk and single-cell levels, including transcriptomic, genomic, epigenomic, functional genomic, chemical genomic and proteomic data to model context-specific cellular/molecular networks and to identify actionable targets, biomarkers or compounds that could be translated into clinic for the development of precision medicine in pediatric cancer. The scientist will report to Dr. Jiyang Yu and will work closely with our collaborators in the departments of Immunology and Oncology for experiment design and data generation, and with our pipeline and visualization teams to explore novel analysis approaches for single-cell RNA-Seq, NGS-based RNAi/CRISPR screening, immune-profiling and proteomics data for molecular network inference and target identification.   Candidates with a strong interest in cancer immunotherapy, cancer precision medicine and expertise in oncology, immunology, computational biology, bioinformatics are encouraged to apply. The successful candidate will also have an opportunity to participate in research projects involved in the analysis of the cancer genome, epigenome, transcriptome or proteome. Experience with omics data analysis using R or Python and familiarity with linux/unix is required. Experience and knowledge in immunology and/or immuno-oncology is highly desirable. Expertise in systems biology, network biology, parallel computing, web development, visualization and databases is also highly desirable.   The Yu Lab provides a highly interactive environment with projects involving basic and clinical research collaborators, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.    
Job ID
44476
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
As a member of the Epidemiology & Cancer Control clinical research team, you will serve as the protocol expert for assigned clinical trials. Our goal is to improve the lives of pediatric cancer survivors through clinical research related to late effects of cancer treatment. Your primary responsibilities will include consenting and enrolling study participants as well as coordinating with other patient care teams throughout the hospital. Clinical Trials and Drug Studies skills are important for this position. Other key skills to possess are  attention to detail, organization and interpersonal  Take the first step to join our team by applying now!
Job ID
44509
Department
Epidemiology & Cancer Control
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine.   St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients. The Department of Structural Biology is seeking a synthetic organic chemist to lead chemistry initiatives in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also lead chemical biology initiatives aimed at advancing the mechanistic study of clinically important biological systems at the single-molecule scale. The highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.   Preferred Skills - Experience designing and performing multiple-step synthesis from commercially available reagents. - Experience in troubleshooting and optimizing chemical reactions and purification techniques. - Experience with moisture-sensitive reactants, conventional chromatographic methods, HPLC purification, LC-MS, and NMR. - Basic knowledge in fluorophore design and good understanding in fluorophore structure -performance relationships. - Ability to carry out multiple projects and responsibilities in parallel, delegating as appropriate. - Expert ability to distill complex information in a clear and concise manner both verbally and in writing.
Job ID
44514
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for experienced biochemists to aid in structural studies of protein kinases. The Senior Researcher will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared resource core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
Job ID
44581
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a highly driven scientist with broad interest in protein kinases, to oversee, organize and coordinate the activities of multiple researchers in a dynamic, comprehensive, inter-disciplinary initiative at the Department of Structural Biology, St. Jude Children's Research Hospital.   The Blue Sky Initiative "Seeing the Invisible in Protein Kinases" is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027, pp 62–63).   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.     We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases. We are looking for an enthusiastic scientist to join this project and take a key organizational role.   This is a high-level staff position, and the Prinicipal Scientist will: - Oversee the activities of over 40 scientists across different teams performing biochemistry, NMR and computational analyses of different kinases. - Organize and integrate the data generated by those teams. - Be the contact point for PIs and team leaders for information on all ongoing projects. - Identify kinases of biological and medical interest as targets - Search and synthesize the relevant literature information on kinase biology as necessary. - Prepare written materials for reports, presentations and publications. - Take a lead on organizing internal and international scientific meetings - Interact with other teams within St. Jude to identify scientific opportunities relevant for the project Furthermore, the ideal candidate should have a track-record of exceptional organizational and problem-solving skills; outstanding communication skills; be able to absorb, synthesize and integrate different types of information; work independently; and thrive on a highly collaborative and fast-moving environment.
Job ID
44542
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for a NMR spectroscopists to study protein kinases. The NMR Senior Researcher will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
Job ID
44583
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support to ensure scientific and clinical progress is never halted from a lack of resources. You will be part of a collaborative environment where you can see, firsthand, the rewards of your hard work. 
Job ID
44624
Department
Cancer Center Administration
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a highly motivated, organized, and responsible individual to lead a major component of Dr. Stephen Mack's new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage and analyze cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors. Applications include short- and long- read WGS, long-isoform sequencing, ChIP-seq, ATAC-seq, and RNA-seq. This candidate will play an integral role in the functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The ideal candidate will have experience in working with genomics datasets, specifically with respect to implementing new algorithms and pipelines, as well as utilizing existing computational software. Knowledge in R, UNIX, Python, and general scripting languages are preferred. He/she will demonstrate a willingness to learn new concepts and technical skills, but most meaningfully harbor an enthusiasm for working in a team-based environment and interfacing with national and international collaborative efforts.  
Job ID
44607
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for experienced NMR spectroscopists to study protein kinases. The NMR Lead Researcher will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  Preferred skills and experience: - Experienced in using multidimensional NMR spectroscopy to study proteins including collection and analysis of three-dimensional noesy data. - Experience in using both automated and manual methods for assignment of backbone and methyl groups. - Working knowledge of protein dynamics using CEST. - Experience in data processing using NMRPipe. - Experienced in NMR structure calculation and refinement. - Independently motivated, detail oriented and good problem-solving ability. - Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment. - Excellent communications skills. St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive
Job ID
44681
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Klco Lab in the Department of Pathology is looking for a Senior Researcher to join our research group. Our lab is broadly focused on the molecular alterations that lead to the development of acute myeloid leukemia and myelodysplastic syndrome in children. We use a variety of approaches, including in vivo murine models, to study how genetic mutations identified in children with these tumors lead to changes in the development of blood cells.   We are seeking a self-motived and detail-oriented team member to assist other lab staff with the management of our mouse colony, to perform various laboratory techniques and to assist in maintenance of lab operations. Exceptional candidates would have experience in nucleic acid preparations, tissue culture and PCR. All candidates are expected to have excellent verbal and written communication skills and the ability to work constructively as a member of a team.
Job ID
44704
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Director of Improvement Science Research will undertake an exciting opportunity at St. Jude! The individual will be responsible to develop a vision and strategy to increase scholarly output by faculty and staff engaged in improvement science.  This position is a critical step for St. Jude to become an academic leader in improvement science for children with catastrophic disease. This position will be expected to foster a culture that embraces rigorous improvement science methods at an institutional level. The Director will guide faculty, and staff to ensure that quality improvement initiatives meet the standard for academic peer-review. This standard is met by collaborating with researchers and establishing structure that guarantees the design, methodology, analysis, and quality of scientific writing of improvement science efforts meets or exceeds scientific norms.    We are looking for someone who takes initiative and enjoys building a program from the ground up. The individual will need to be able to effectively communicate to a diverse range of internal customers. The selected candidate will be also able to balance providing strategic vision for the team and able to be hands on supporting customers. If this position sounds exciting to you, we look forward to reviewing your resume and application.
Job ID
44472
Department
Office of Quality/Pt Care Ops
Company
St. Jude Children's Research Hospital
Type
Full Time
The Moldoveanu lab is seeking a highly motivated cryo-EM structural biologist to work on interdisciplinary projects at the interface of integrated structural biology and biochemistry of proteins implicated in programmed cell death.   The successful candidate takes a leadership role in applying cryo-EM analysis in characterization of macromolecular complexes implicated in programmed cell death. He or she is expected to: - perform all aspects of single particle cryo-EM analysis independently, including negative staining, grid freezing, data collection and processing, and model building and refinement  - interpret structures to generate hypothesis for functional investigations - prepare and draft relevant sections of papers and grants - interface with the cryo-EM center in training new lab members The ideal candidate will have an academic record of innovative independent research using cryo-EM (papers in the field), hands-on experience with cryo-EM instrumentation, strong background in computational aspects of cryo-EM analysis, experience with sample manipulation for cryo-EM (e.g. purification, crosslinking), excellent oral, presentation, and written communication skills.   The successful candidate will join a highly collaborative team with expertise in biochemistry and structural biology focused on elucidating mechanisms of cell death signaling in the Department of Structural Biology with access to state-of-the-art cryo-EM instrumentation including Titan Krios, Talos Arctica, and Talos L120C. The Department has outstanding infrastructure and expertise in cryo-EM, X-ray crystallography, NMR spectroscopy, protein technologies, proteomics and metabolomics, and single molecule techniques. St. Jude Children’s Research Hospital is a Fortune 100 Best Company to work for. St. Jude offers highly competitive salary and benefits. We are in Memphis, Tennessee, a city newcomers and natives love to call home. It is friendly, affordable, clean, great for young families, and offers excellent quality of life.  
Job ID
44710
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time

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