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The World’s Brightest Minds Always Innovate    At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big, and we give you everything you need to be the force behind our cures.    The Northcott Lab in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital is internationally renowned for being a leading research group in the genomics and developmental biology of childhood brain tumors. We are seeking a highly motivated and experienced Scientific Manager to assist with the day-to-day management of a sizable laboratory of trainees and technical staff conducting basic and translational research projects with a primary focus on medulloblastoma, the most common malignant childhood brain tumor.  
Job ID
42504
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.   The laboratory of Dr.Chia-Hsueh Lee in the Structural Biology Department strives to elucidate the molecular mechanism and function of membrane signaling complexes using cryo-EM and biochemical/biophysical approaches. The lab has full access to the state-of-the-art cryoEM facility in St. Jude, which houses a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope, both equipped with a K3 detector and energy filter. We are seeking a highly motivated staff research scientist to join Dr. Lee’s lab at SJCRH. This scientist will lead research projects focusing on structural mechanisms of neuronal membrane proteins and assist Dr. Lee with lab operations. The ideal candidate should have good communication skills and a collaborative attitude. Project management, scientific writing and expertise in structural biology (single particle cryo-EM or X-ray crystallography) would be a plus.    
Job ID
42711
Department
Structural Biology
Company
St. Jude Children's Research Hospital
We are seeking for a Research Technologist to focus on translational research support for pediatric solid tumor and brain tumor programs as directed by the DNB Director of Operations and Chair. This position involves assisting with the collection and processing of biological specimens, routine colony maintenance and administration of substances techniques, facilitates specimen inventory and sample shipping worldwide, and maintains detailed records of ongoing scientific projects. Additionally, this person will interact with multiple institutional departments and collaborate on projects and initiatives. Assists with the management of laboratory operations. Performs other related duties as assigned or directed in order to meet the goals and objectives of the department.   *Position will require occasional work after hours, on call and on weekends/holidays (rotational).  
Job ID
42987
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
A Bioinformatics Research Scientist position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to perform computational analysis for understanding 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will develop innovative methods and perform analysis to determine haplotype phasing using chromatin contact maps and for investigating heterogeneity in 3D genome architecture at the level of single cell.   The successful candidate will have good training in human genetics and bioinformatics analysis. Additional training and experience in epigenetics and cancer biology are preferable. The candidate is expected to be a critical thinker, a quick learner for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidate must have a PhD, an excellent publication record, and great communication skills.   Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics and computer science. St. Jude provides a highly interactive and supportive environment for researchers’ career development.    
Job ID
43035
Department
Collaborative Research Program
Company
St. Jude Children's Research Hospital
We are seeking a highly talented and motivated Bioinformatics Clinical Scientist to join the Department of Pathology at St. Jude Children's Research Hospital. In this role, you will work in multi-disciplinary teams of pathologists, molecular biologists, computational biologists and software engineers to design, develop, validate, implement and continually improve advanced computational pipelines for next generation sequencing (NGS) analysis of tumor and germline data for clinical and translational research applications. You will refine methodologies for data analysis, processing, visualization and storage. You will assist in preparing clinical validation and protocol documents, as well as manuscripts. This is an exciting opportunity to join a dynamic, collaborative group developing cutting edge analytical technologies for high-throughput sequencing and other complex molecular assay data.  
Job ID
43333
Department
Pathology
Company
St. Jude Children's Research Hospital
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources.     The St. Jude Protein Production Facility provides protein expression and purification services to support the translation of discoveries in molecular and cellular biology to chemical and structural biology. The facility offers state-of-the-art technologies for protein expression/purification from bacterial, insect cell and mammalian systems. The facility has worked with many St. Jude investigators, expressing and purifying almost 2,000 different proteins for use in structural and biochemical characterization, high-throughput screens, and use as reagents or antigens. The facility aims to help investigators obtain pure proteins for biochemical assay and structure determination for the development of new anti-cancer and anti-infective drugs.   Contributing to our mission of finding cures and saving children, the Protein Production Facility at St. Jude Children’s Research Hospital is looking for an experienced researcher to join the facility as a Sr. Research Technologist or Research Laboratory Specialist to provide support and assistance to different departments and investigators at SJCRH.  
Job ID
F1172
Department
Protein Production
Company
St. Jude Children's Research Hospital
We are seeking a highly motivated and creative bioinformatics research analyst to join Dr. Martine Roussel's team in the Tumor Cell Biology Department at St. Jude Children's Research Hospital to develop and apply innovative analytical approaches in the area of functional genomics. You will collaborate with St Jude investigators to analyze data such as single cell RNA-seq, single cell ATAC-seq, bulk RNA-seq, DNA methylation, ChIP-seq, to understand the tumor biology, tumor-infiltrating lymphocytes and neurobiology and help the investigators prepare manuscripts and grant applications. Experience with programming languages such as Python and R are preferred. You will also lead the evaluation of published bioinformatics tools and develop the optimized pipeline to share with scientists at St Jude. The department provides a highly interactive environment with collaborative opportunities, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. Candidates with a strong background in statistics, computational biology, machine learning, and experience using systems biology approaches to understand the mechanisms of action of disease or experimental intervention are highly encouraged to apply for this position. This position is located in Memphis, TN, and relocation assistance is available.    
Job ID
43342
Department
Tumor Cell Biology
Company
St. Jude Children's Research Hospital
Focuses on one or more specific scientific endeavors of the laboratory as directed by the Associate or Full Member. Utilizes unique, advanced skills in achieving the highest research goals. Develops new experimental procedures and publishes research results. Initiates and conducts independent experiments without direct supervision. Assists with the management of laboratory operations. Performs other related duties as assigned or directed in order to meet the goals and objectives of the department.
Job ID
43384
Department
Ctr-Ped Neurological Dis Res
Company
St. Jude Children's Research Hospital
This position is an outstanding opportunity for a highly motivated candidate to join as a Staff Scientist in Dr. Ji Sun’s group in the Structural Department. Dr. Sun's laboratory will focus on the structure and function of important membrane proteins and protein complexes. For more details about Dr. Sun’s previous research, please check his publications. In this position, you will   ·     design and perform complex experiments and analyze data independently.   ·     develop new experimental procedures and publish research results  ·     train and supervise lab members on relevant laboratory procedures and techniques.  ·     assist with day-to-day operation of the lab  Strong background in structure biology, biochemistry or related fields and training in cryo-EM or membrane protein biology preferred.     
Job ID
42257
Department
Structural Biology
Company
St. Jude Children's Research Hospital
The Department of Developmental Neurobiology (DNB) at St. Jude Children's Research Hospital is seeking a motivated Data Scientist to join its Neuroimage Analysis Core. Researchers in DNB study the neural circuits that underly neuropsychiatric disorders, arousal, attention and motor function. Recent advances in machine learning have enabled a revolution in how animal behavior is studied. These new approaches enable insights into how neural circuits contribute to behavior. You will join a dynamic team in DNBs fast-paced research environment to apply machine learning approaches in the analysis of animal behavior and develop innovative solutions to advance our understanding of the role of individual neural circuits in complex behaviors. You will work closely with the Neuroimage Analysis Core, the Neurobehavior Core and the Center for Bioimage Informatics.   Preferred experience • Experience in deep learning is preferred. • Experience in using machine learning to analyze time-series data is preferred. • Experience in using computer-vision for tracking and pose-estimation is preferred. • Experience in using established image analysis platforms (e.g.: ImageJ/Fiji, CellProfiler) is preferred. • Experience in working with large image data volumes is preferred. • Experience in biological/medical imaging is preferred.  
Job ID
43083
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
St. Jude Children’s Research Hospital is seeking multiple Bioinformatics Research Scientists to study the role of genome and other nuclear organization in pediatric cancers. Recognized for state-of-the-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise, St. Jude offers a work environment where you will directly impact the care of pediatric cancer patients. As a Bioinformatics Research Scientist, your responsibilities include analyzing data generated from a variety of second- and third-generation sequencing applications that interrogate a broad range of human gene regulatory biology.   The Abraham lab studies gene expression-regulation mechanisms in healthy and diseased mammalian cells. We are recruiting computational biologists to collaboratively develop computational tools and frameworks to analyze high-throughput sequencing (-omics) data.  We build analytical software pipelines to find answers to biological questions about gene regulation in big datasets, usually from applied sequencing experiments like ChIP-Seq, RNA-Seq, and Hi-ChIP. Our interests center on enhancers and super-enhancers. Specifically, we seek to understand how these regulatory elements establish gene expression programs in healthy cells, and how enhancers are altered by mutation, abused by mistargeting, and targetable with drugs in diseased cells.  We focus on characterizing the core regulatory circuitries driving disease-relevant cells, and on understanding how mutations in the non-coding DNA of such cells can drive disease, including cancers, through gene misregulation.     The successful candidate will become a fundamental component of a multidisciplinary, inter-institutional team assembled to study how genome structures meaningfully differ between normal and pediatric cancer cells.    Ideal candidates will have experience building, tailoring, and deploying analysis pipelines using widely available genomic analysis toolkits (e.g. bedtools, samtools), as well as experience managing large numbers of datasets.  The successful candidate will be tasked with collaborative research within and beyond the lab, so strong communication and interpersonal skills are essential.  Additional experience in fundamental understanding of gene expression mechanisms (e.g. transcription factors, enhancers, genome structure, and transcriptional condensates), and experience building succinct, clear figures using R are preferred.   The department of Computational Biology provides access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with experience in data analysis, data management and delivery of high-quality results for competitive projects. We encourage first author, high profile publications to share this element of discovery. Take the first step to join our team by applying now!   Relevant Papers:   Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, Mansour MR, Young RA. Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun. 2017 Feb 9;8:14385. doi: 10.1038/ncomms14385. PubMed PMID: 28181482; PubMed Central PMCID: PMC5309821.   Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 2013 Nov 7;155(4):934-47. doi: 10.1016/j.cell.2013.09.053. Epub 2013 Oct 10. PubMed PMID: 24119843; PubMed Central PMCID: PMC3841062.   Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell. 2014 Oct 9;159(2):374-387. doi: 10.1016/j.cell.2014.09.030. PubMed PMID: 25303531; PubMed Central PMCID: PMC4197132.    
Job ID
42082
Department
Computational Biology
Company
St. Jude Children's Research Hospital
The Cell and Tissue Imaging Center at St. Jude Children’s Research Hospital is looking for a talented and driven electron microscopist to join the Center at the Associate Scientist level.   The electron microscopy facility houses a Thermo Fisher Scientific F20, a Helios FIB/SEM and a Teneo VolumeScope SEM as well as a variety of equipment for sample preparation including Leica tissue processors and ultramicrotomes, equipment for low temperature processing and multiple vacuum evaporators. The facility is funded by the Hospital and is utilized by faculty from across the research departments, providing world class imaging to the investigators at St. Jude. Staff members in the Center collaborate with investigators on a variety of research projects from standard tissue pathologies through three-dimensional imaging projects by electron tomography or volume SEM and have the opportunity to participate in development of techniques and protocols to drive St. Jude’s research forward.   This position requires experience in biological electron microscopy. Skill sets in volume SEM (scanning block face SEM, array tomography, and FIB/SEM) and/or high pressure freezing and freeze substitution are highly desirable.     
Job ID
43138
Department
Cellular Imaging Shared Resources
Company
St. Jude Children's Research Hospital
Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics, and Nature Methods. The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management, and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.   The department of Computational Biology is seeking a highly motivated and creative Associate Product Owner to serve as a user advocate and key point of contact for the St. Jude Cloud project. The Associate Product Owner will manage the software development lifecycle, oversee and participate in the process of preparation, annotation, and maintenance of genomic data files on St. Jude Cloud, and oversee the process for St. Jude Cloud data access. This position will regularly deal with diverse matters which require extensive knowledge of St. Jude Cloud and the successful candidate will possess the ability to handle sensitive situations in a mature and confidential manner.    
Job ID
42751
Department
Computational Biology
Company
St. Jude Children's Research Hospital
At St. Jude, we are translating science into survival with breakthroughs that are advancing the fight against childhood cancer and other pediatric illness. The Chemical Biology & Therapeutics department at St. Jude Children's Research Hospital is looking for a motivated scientific visualization engineer or medical illustrator to join their team. The department’s research focuses on discovery of new bioactive small molecules, and developing therapeutic lead compounds. In this role you will design, develop and provide visualization methods, algorithms, software applications and technology platforms that are used to display multi-dimensional research data in interactive visual graphics and/or render 2D/3D representation of complex biological systems for the advancement of basic and translational scientific research. This role works collaboratively with a variety of departments to develop ideas, and create visualization materials necessary to communicate research data to target audiences.   To be successful in this role the following list of skills, knowledge and abilities are preferred. - Proficiency in theory and practices for visualization of complex high-dimensional scientific data, and the computational sciences needed to implement visualization methods at extreme scale. - Proficiency with modern high-level programming language. - Ability to create animation on the molecular, cellular and gross level through all stages of production including concept, script, storyboarding, draft animatics, final animation, rendering, and post-production. Advanced experience in 3D modeling, animating, shading, and lighting.  - Proficiency with or ability to learn protein structure visualization software.  - Strong writing skills to translate scientific concepts to a lay audience. - Familiarity with disseminating scientific information on social media applications. - Innovative capacity to solve technology gaps. - Strong analytical and critical thinking skills. - Effective communication and interpersonal skills - Excellent presentation skills for demo and user training, writing skills for user documentation. - Self-motivated, independent and able to learn quickly. - Teaching skills in both individual and group settings. - Ability to work in a fast-paced environment. - Resourcefulness in finding solutions to problems. - Adaptable to changing goals and outcomes.
Job ID
43256
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
The goal of the Department of Infectious Diseases at St. Jude Children’s Research Hospital is to study devastating diseases of childhood through a comprehensive approach including basic science research, translational trials, and bedside care, and we’re seeking a strategic thought partner and leader to help guide the trajectory of our HIV prevention and treatment program as we grow.   Here at St. Jude, our mission is at the center of all we do, and we’re honored to lead HIV prevention and treatment research for children and youth on a national stage: managing a multimillion-dollar, grant-funded portfolio, designing and implementing ground-breaking new protocols, and leading high-profile clinical trials. In this unique role, you’ll lead a tight-knit, high-performing team of clinical research associates, managing the ebb and flow of cases and protocols while collaborating across departments to drive our mission forward.   St. Jude is leading the way the world understands, treats and defeats childhood cancer and other potentially life-threatening diseases such as HIV infection, and we encourage applicants whose aspirations match the caliber of our work. If you're passionate about research, thrive in collaborative environments, and are a strategic leader with a heart for bold, mission-driven work, we’d love to have you apply.  
Job ID
F1162
Department
Infectious Diseases
Company
St. Jude Children's Research Hospital
Research in the Schwarz lab focuses on how neuromodulatory circuits in the brain are organized to regulate complex behaviors. Using in vivo methods, such as viral tracing, optogenetics, and calcium imaging, we aim to identify how small populations of neurons can differentially regulate the brain depending on the situation. These neuronal circuits have also been implicated in several neurological disorders, such as depression, anxiety, and Alzheimer’s disease. Therefore, we would like to know how the organization of these circuits change during disease progression.   We are seeking a highly motivated individual with an interest in neuroscience or cell biology research. The ideal candidate is detail-oriented and has laboratory experience.  People with experience in molecular approaches and working with in vivo models, as well as administrative and organizational skills, are encouraged to apply. 
Job ID
F1171
Department
Developmental Neurobiology (Neural circuits and behavior)
Company
St.Jude Children's Research Hospitla
Overview: There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers.    About the position Ideal candidate will have 2+ years of experience in clinical biomedical and/or behavioral research.   The Clinical Research Associate RN II is a registered nurse who operates under general supervision and acts as site Study Coordinator.  The selected candidate will serve as a preceptor/mentor to new clinical research staff. Performs data abstraction, collection, and entry to support clinical research. Prepares submission for all reportable events and develops, maintains, and/or monitors case report forms and ensures compliance with prescribed interventions and evaluations of the assigned protocol(s). Provides data to the collaborating research organization or study sponsor. Prepares data reports. Provides patient care, education, and management. Position has a dotted line reporting relationship to the Nursing Executive/CNO. Coordinates with Supervisor and Nursing Executive/CNO to ensure consistent institution-wide compliance with standards of nursing practice.   About the Department of Radiation Oncology Known for setting standards in technical delivery of radiotherapy and clinical trials, the Department of Radiation Oncology is a full-service department dedicated to clinical research and treatment of 300 children, adolescents, and young adults each year. With the mission of providing expert and compassionate clinical care, the department is the largest group of experts devoted to pediatric radiation oncology who collectively treat more children than any other cancer center or hospital in the country. The department includes: -  Multidisciplinary team: Pediatric radiation oncologists, physicists, dosimetrists, radiation therapists, registered nurses, nurse practitioners as well as supportive research teams (anesthesia, sedation, social work and child life specialists to name a few). -  World-class resources: This includes the first worldwide installation of detector-based spectral CT and digital PET/CT in a Radiation Oncology Department, state-of-the-art 1.5T and 3T MR scanners (radiotherapy simulators), a dedicated PET/CT and the world’s first proton therapy center with pencil beam scanning technology designated solely for the treatment of pediatric cancer. -  State-of-art facility: The department has 20,000 square feet of clinical space that includes a clinic, treatment planning, therapy, anesthesia and sedation support. There are two linear accelerator systems with image-guidance, a HDR/fluoroscopy suite, and spectral CT and 1.5T MR systems dedicated to treatment planning. The adjacent 25,000 square feet St. Jude Red Frog Events Proton Therapy Center includes two gantry rooms and a fixed beam room; each equipped with high-precision patient positioning, volumetric image-guidance systems, and dedicated scanning nozzles.    
Job ID
43020
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Operates as an advanced-level Research Technologist by assisting the principal investigator with the data collection and analysis for research projects. Properly conducts specific projects, maintains efficient laboratory operations and may assist in training other laboratory personnel. Performs other duties as assigned or directed in order to meet the goals and objectives of the department.
Job ID
43239
Department
Hematology
Company
St. Jude Children's Research Hospital
Operates as an advanced-level Research Technologist by assisting the principal investigator with the data collection and analysis for research projects. Properly conducts specific projects, maintains efficient laboratory operations and may assist in training other laboratory personnel. Performs other duties as assigned or directed in order to meet the goals and objectives of the department.
Job ID
42681
Department
Center for In Vivo Imaging & Therapeutics
Company
St. Jude Children's Research Hospital

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