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The goal of the Department of Infectious Diseases at St. Jude Children’s Research Hospital is to study devastating diseases of childhood through a comprehensive approach including basic science research, translational trials, and bedside care, and we’re seeking a strategic thought partner and leader to help guide the trajectory of our HIV prevention and treatment program as we grow.
Here at St. Jude, our mission is at the center of all we do, and we’re honored to lead HIV prevention and treatment research for children and youth on a national stage: managing a multimillion-dollar, grant-funded portfolio, designing and implementing ground-breaking new protocols, and leading high-profile clinical trials. In this unique role, you’ll lead a tight-knit, high-performing team of clinical research associates, managing the ebb and flow of cases and protocols while collaborating across departments to drive our mission forward.
St. Jude is leading the way the world understands, treats and defeats childhood cancer and other potentially life-threatening diseases such as HIV infection, and we encourage applicants whose aspirations match the caliber of our work. If you're passionate about research, thrive in collaborative environments, and are a strategic leader with a heart for bold, mission-driven work, we’d love to have you apply.
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.
This is an exciting opportunity for a self-motivated scientist to join the Immunology Department at SJCRH in the laboratory of Dr. Thirumala Devi-Kanneganti. Our laboratory extensively employs murine models to understand how the innate immune system recognizes and responds to pathogens and how genetic mutations in innate immunity affect the development of infectious, inflammatory, and autoimmune diseases in humans.
This position is involved in the cGMP manufacturing of patient-specific cellular gene therapy products. The selected person will be part of a cGMP cellular gene therapy (CGT) manufacturing team that works closely with the Experimental Cellular Therapy (ECT) group responsible for the development of cellular gene therapy products. The cGMP CGT manufacturing team, under the direction of the Processing Facility Director, is responsible for the cGMP manufacturing of all cellular gene therapy products used by St. Jude in Phase I/II clinical trials.
At St. Jude, we are translating science into survival with scientific breakthroughs that are advancing the fight against childhood cancer and other pediatric illness. The Kanneganti laboratory is seeking a highly motivated and team-oriented science research writer to support the development, submission, and publication of the lab’s research articles and reviews and draft and maintain technical documents. The lab investigates signaling pathways involved in innate immunity and cell death with a particular focus on NLRs and inflammasomes and understanding how these pathways connect.
Successful candidates will have experience in manuscript writing, excellent critical thinking, problem-solving and a keen attention to detail. You are expected to work onsite in Memphis, TN at St. Jude Children's Research Hospital.
As a Clinical Research Associate II in the Neuropsychology Section of the Psychology Department, you will support Faculty Investigators examining cognitive outcomes related to treatment for childhood catastrophic diseases and evaluating interventions addressing these issues. Studies focus primarily on brain tumor, leukemia, and sickle cell disease.
The ideal candidate will have training and experience in cognitive testing (typical batteries for testing include measures of intelligence, attention, memory, and parent report measures). Attention to detail and organizational skills are essential in coordinating data across multiple disciplines and collaborating sites.
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior cell and molecular biologist/chemical biologist to design and implement a variety of cell-based phenotypic screens, ranging from large-scale automated cytotoxicity screens, medium-scale genetic loss-of-function siRNA screens, to focused high-content imaging-based screens. The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The HTS Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 600K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.
Directs, initiates and executes research strategies in partnership with Principal Investigator. Designs and conducts studies to investigate specific basic science or clinical research questions within field of expertise. Focuses on one or more specific scientific endeavors of the laboratory. Develops new experimental procedures and publishes research results.
The laboratory of Shengdar Q. Tsai is seeking outstanding, highly motivated, and creative candidates for a Scientist, starting in June 2021, to define and improve genome editing strategies for treatment of sickle cell disease. The ideal candidate will have experience with genome editing technologies, human hematopoietic stem cells, or high-throughput genomics.
You will have the opportunity to work with a group of talented interdisciplinary team of scientists to develop autologous cell therapies with the goal of treating patients here at St. Jude Children’s research hospital and worldwide. Examples of exciting projects include:
- Optimizing pre-clinical CRISPR-Cas gene editing strategies for treating sickle cell disease by induction of fetal hemoglobin as a replacement for adult sickle hemoglobin.
- Developing strong pre-clinical data to support advancing potentially curative, autologous cell therapy approaches to treating SCD.
- Protein engineering of CRISPR-Cas genome editors with improved activity, targeting range, or specificities.
- Define the safety or genome-wide activities of therapeutic genome editors.
In this position, you will gain extensive experience and training in genome editing, sickle cell disease, high-throughput genomics, and characterization of human hematopoietic stem cells. We strongly support the career development of lab members through opportunities to publish in high-impact journals and present work at academic conferences.
For more information about our lab and recent publications visit: www.tsailab.us
*Please include a cover letter with your application that will be reviewed directly by Dr. Tsai.
As a Clinical Research Associate-RN III reporting to the Director of the Division of Anesthesiology, you will provide support to our faculty-initiated studies. When a faculty member has new project ideas, you are there to assist with research and proposals while also attending stakeholder meetings. Research has been focused on pain management, yet the scope of projects is about to expand with your help. Other responsibilities include enrolling and educating participants on active studies, updating databases, reviewing research findings, and developing patient safety initiatives. You will enjoy this job if you have a passion for quality and safety as well as a desire to drive studies forward in the clinical research arena. Take the first step to join our team by applying now!
The Department of Global Pediatric Medicine (GPM) is a new and growing department looking for professionals who are eager to help implement the mission of taking St. Jude to the world by training the clinical workforce, developing and strengthening health systems and patient-centered initiatives, and advancing knowledge to sustain continuous improvement through research. GPM is seeking a Clinical Research Associate II- NACHO.
The North American Consortium for Histiocytosis (NACHO) was formed in July 2014 by clinicians and scientists from twelve North American institutions dedicated to developing a research infrastructure to effectively implement clinical and translational studies and conduct biological research of histiocytic diseases. While many other initiatives will be developed and executed in the future, one of our aims is to rapidly design and implement high-impact clinical trials. NACHO currently has over 60 member sites, and 4 clinical trials in progress. The NACHO Operations Center is housed at St. Jude Children’s Research Hospital in Memphis, TN.
Are you ready to join St. Jude Children's Research Hospital? Well this may be the opportunity for you! As a member of the Epidemiology & Cancer Control clinical research team, you will serve as the protocol expert for assigned clinical trials. Our goal is to improve the lives of pediatric cancer survivors through clinical research related to late effects of cancer treatment. Your primary responsibilities will include coordinating the day-to-day activities of a new research study, consenting and enrolling study participants, as well as coordinating with other team members across multiple institutions. Take the first step to join our team by applying now! NOTE: This is a grant-funded position.
The Cell and Tissue Imaging Center at St. Jude Children’s Research Hospital is looking for a talented and driven Senior Researcher to join the electron microscopy lab.
The Senior Researcher
- Utilizes an established skill set in electron microscopy and histology (tissue processing, resin embedding, ultramicrotomy, & electron microscopy) to assist St. Jude researchers (principal investigators, research staff, post-doctoral fellows, and graduate students) in achieving the results needed to advance their research goals.
- Performs basic workflows and experiments without direct supervision and advanced and specialized workflows with some direct supervision.
- Works to further develop electron microscopy skill sets (serial sectioning, low temperature and microwave processing protocols, advanced microscopy techniques). Participates in the development of procedures and participates in the publication of research results and may manages or be responsible for various laboratory operations. Pursues advanced knowledge in sophisticated methodology in the electron microscopy field.
- Performs other related duties as needed to successfully execute research projects and meet the goals and objectives of the department.
This position requires experience in preparing and imaging biological samples by electron microscopy.
The Mefford Lab in the Center for Pediatric Neurological Disease Research at St. Jude Children’s Research Hospital uses genome-wide approaches to identify genetic, genomic and epigenetic causes of human disease including epilepsy, and related pediatric neurodevelopmental disorders. The major focus of our current work is to identify causes of pediatric epilepsy by employing state-of-the-art technologies including whole exome sequencing, targeted gene panel sequencing and custom array comparative genomic hybridization (aCGH). The Mefford lab has discovered numerous new epilepsy genes and copy number variants, including deletions of chromosomes 1q21, 15q13 and 17q12, each of which cause a range of clinical features.
The Bioinformatics Research Scientist/Lead Bioinformatics Analyst will take a prominent role in our research and collaborations to analyze multiple types of genomics data: exome and genome sequence, bulk RNA-seq, single cell/nuclei RNA-seq, methylation, SNP array, and others to identify variants associated with human genetic conditions and understand their underlying mechanisms. The ideal candidate will be capable of self-directed research within broader goals set by group, have previous experience with next-generation sequence data analysis highly desirable, knowledge of statistical/mathematical packages such as R.
The Center for Pediatric Neurological Disease Research (CPNDR) is in search for a Research Operations Manager to manage the core facilities and coordinate the overall daily lab operations.
The successful candidate will have education and knowledge in neuroscience, have initiative, and the ability to work independently. The successful candidate will be expected to run and maintain a state-of-the-art histology and tissue processing core that will serve members of the CPNDR, DNB and associated St. Jude neuroscience investigators. The successful candidate will provide guidance for broad histology and tissue processing methodologies and will serve and help build collaborative relationships across the St Jude neuroscience community. Operational priorities will include ensuring the core is performing at a high level of service and operations and also helping promote the CPNDR to neuroscience Investigators at St. Jude Children's Research Hospital.
St. Jude department of Epidemiology & Cancer Control is searching for a Senior Coordinator of Clinical Research Operations to join the team. This team works on one of the world’s most robust survivorship studies collecting critical longitudinal data. You will play a key role in coordinating both survey-based and intervention studies. Primarily, you will manage important project activities and timelines, prepare data reports, and submit regulatory documents. As the Senior Coordinator of Clinical Research Operations and as a member of the Epidemiology & Cancer Control team, you are an integral leader for studies that impact both survivors and current patients. A nurse with research and/or drug study experience is highly preferred for this role. Take the first step to join our team by applying now! **This is a grant funded position.**
This is an opportunity for a skilled Lead Researcher in the Cancer Biomarkers Laboratory, in the Department of Pathology at St. Jude Children’s Research Hospital. The laboratory is an Institutional Shared Resource Laboratory where we design and perform correlative molecular studies for investigator-led clinical trials. We also have a role in evaluating and developing novel technologies for the discovery and measurement of biomarkers relevant to pediatric catastrophic diseases. Our goal is to transition novel methods and technologies into the clinical diagnostic service in the Department of Pathology.
The successful applicant should have experience in genomic research, particularly the wet lab aspects of standard DNA and RNA-based genomic studies including library preparations, quality assessments, capture hybridization and enrichment. Applicants should also have a diverse skill set in laboratory research, including experience in nucleic acid extraction, molecular cloning, mammalian cell culture and immunoassays.
Expectations for this position include rigorously designing, testing, evaluating, troubleshooting and implementing novel assays and experimental techniques, as needed for evolving lab priorities. The selected candidate should be able to work effectively to deadlines with minimal specific supervision and manage multiple projects. Strong organizational skills, meticulous attention to detail, good interpersonal communication skills and the ability to work in a dynamic, collaborative team environment are essential.
St. Jude Children's Research Hospital is consistently ranked on Fortune Magazine's "100 Best Places to Work For" list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve.
This is an exciting opportunity for a self-motivated person to join Dr. Krenciute’s laboratory in the Department of Bone Marrow Transplantation and Cellular Therapy at St. Jude. The research focus is to develop an effective immunotherapy for brain tumors using genetically modified T cells. Our goal is to generate and optimize CAR-T cells to target pediatric brain tumor associated antigens and to understand tumor escape mechanism in order to design superior immunotherapy treatments. This research employs different genetic manipulations of CAR T-cell effector functions to reduce resistance to tumor microenvironment.
The department of Computational Biology is seeking a highly motivated Sr. Bioinformatics Research Scientist to serve as the scientific lead for St. Jude Cloud, a cloud-based ecosystem for data sharing, cloud-computing and dynamic visualization of the world’s largest pediatric cancer genomic data set. The candidate will be a part of an interdisciplinary team consisting of scientists and engineers from St. Jude and our external partners at DNAnexus and Microsoft. Specific responsibilities include providing scientific guidance for the engineering team, organizing pilot studies to evaluate collaborative research initiatives, developing prototypes of workflow and designing new concepts for data visualization, performing curation on data releases, and participating in presentation and training of St. Jude Cloud platform to the biomedical community.
Candidates with a strong background in bioinformatics, computational biology, and cancer genomics are highly encouraged to apply for this position. Successful candidates shall have well-established track record in cancer genomic research, in-depth experience in data analysis, excellent critical thinking and communication skills, as the St. Jude Cloud project is an institutional strategic initiative and this position will frequently interact with senior scientists from departments across the institution, as well as external partners and collaborators.
Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics and Nature Methods. The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management and delivery of high-quality results for highly collaborative projects. This position is located in Memphis, TN, and relocation assistance is available.
A Bioinformatics Research Scientist position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to perform computational analysis for understanding 3D genome architecture in pediatric cancer. The candidate with be part of the 3D Genome Collaborative Research Consortium formed by distinguished researchers at St. Jude, Dana-Faber Cancer Institute, and MIT. The candidate will develop innovative methods and perform analysis to determine haplotype phasing using chromatin contact maps and for investigating heterogeneity in 3D genome architecture at the level of single cell.
The successful candidate will have good training in human genetics and bioinformatics analysis. Additional training and experience in epigenetics and cancer biology are preferable. The candidate is expected to be a critical thinker, a quick learner for new analytical approaches, and capable of applying or developing novel computational methods for solving complex problems. Candidate must have a doctoral degree (PhD or MD), an excellent publication record, and great communication skills.
Recognized as a world leader of genomic research in pediatric cancer, the Zhang lab has led the characterization of the genomic landscape for over 20 subtypes of pediatric cancers with high-impact publications in Nature, Nature Genetics, Nature Methods, JAMA, Cancer Cell, and NEJM in the last five years. The lab has a well-established track record of developing and publishing novel and high-impact analytical and visualization tools for cancer genomic research. Research in the lab is facilitated by access to the wealth of high-quality data, state-of-art high performance computing facility, robust analytical pipelines, latest laboratory technology and scientific expertise in genomics, cancer biology, and mathematics and computer science. St. Jude provides a highly interactive and supportive environment for researchers’ career development.
The Halic lab in the department of Structural Biology is seeking a motivated supervisor/manager to join his team. The Halic lab studies the epigenetic regulation of gene expression using genetics, molecular biology, biochemistry and structural biology. In particular you will focus on protein purification and study heterochromatin formation and chromatin-modifying proteins. Currently there are several projects ongoing in the laboratory involving the use of cryo-EM to address processes involved in chromatin organization. We also use genetics and molecular biology to address heterochromatin formation in fission yeast as a model system. In this role you will coordinates and assists in the training for laboratory personnel, ensure that the laboratory complies with regulatory requirements, writes manuscripts and presents the research. You will engage in research projects (75%) and manage daily wet lab operations (25%).