St. Jude Children’s Research Hospital is seeking multiple Bioinformatics Research Scientists to study the role of genome and other nuclear organization in pediatric cancers. Recognized for state-of-the-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise, St. Jude offers a work environment where you will directly impact the care of pediatric cancer patients. As a Bioinformatics Research Scientist, your responsibilities include analyzing data generated from a variety of second- and third-generation sequencing applications that interrogate a broad range of human gene regulatory biology.
The Abraham lab studies gene expression-regulation mechanisms in healthy and diseased mammalian cells. We are recruiting computational biologists to collaboratively develop computational tools and frameworks to analyze high-throughput sequencing (-omics) data. We build analytical software pipelines to find answers to biological questions about gene regulation in big datasets, usually from applied sequencing experiments like ChIP-Seq, RNA-Seq, and Hi-ChIP. Our interests center on enhancers and super-enhancers. Specifically, we seek to understand how these regulatory elements establish gene expression programs in healthy cells, and how enhancers are altered by mutation, abused by mistargeting, and targetable with drugs in diseased cells. We focus on characterizing the core regulatory circuitries driving disease-relevant cells, and on understanding how mutations in the non-coding DNA of such cells can drive disease, including cancers, through gene misregulation.
The successful candidate will become a fundamental component of a multidisciplinary, inter-institutional team assembled to study how genome structures meaningfully differ between normal and pediatric cancer cells.
Ideal candidates will have experience building, tailoring, and deploying analysis pipelines using widely available genomic analysis toolkits (e.g. bedtools, samtools), as well as experience managing large numbers of datasets. The successful candidate will be tasked with collaborative research within and beyond the lab, so strong communication and interpersonal skills are essential. Additional experience in fundamental understanding of gene expression mechanisms (e.g. transcription factors, enhancers, genome structure, and transcriptional condensates), and experience building succinct, clear figures using R are preferred.
The department of Computational Biology provides access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with experience in data analysis, data management and delivery of high-quality results for competitive projects. We encourage first author, high profile publications to share this element of discovery. Take the first step to join our team by applying now!
Abraham BJ, Hnisz D, Weintraub AS, Kwiatkowski N, Li CH, Li Z, Weichert-Leahey N, Rahman S, Liu Y, Etchin J, Li B, Shen S, Lee TI, Zhang J, Look AT, Mansour MR, Young RA. Small genomic insertions form enhancers that misregulate oncogenes. Nat Commun. 2017 Feb 9;8:14385. doi: 10.1038/ncomms14385. PubMed PMID: 28181482; PubMed Central PMCID: PMC5309821.
Hnisz D, Abraham BJ, Lee TI, Lau A, Saint-André V, Sigova AA, Hoke HA, Young RA. Super-enhancers in the control of cell identity and disease. Cell. 2013 Nov 7;155(4):934-47. doi: 10.1016/j.cell.2013.09.053. Epub 2013 Oct 10. PubMed PMID: 24119843; PubMed Central PMCID: PMC3841062.
Dowen JM, Fan ZP, Hnisz D, Ren G, Abraham BJ, Zhang LN, Weintraub AS, Schujiers J, Lee TI, Zhao K, Young RA. Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes. Cell. 2014 Oct 9;159(2):374-387. doi: 10.1016/j.cell.2014.09.030. PubMed PMID: 25303531; PubMed Central PMCID: PMC4197132.
The World’s Brightest Minds Always Innovate
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities. State-of-the-art technologies. Extraordinary support. And a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big, and we give you everything you need to be the force behind our cures.
The Northcott Lab in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital is internationally renowned for being a leading research group in the genomics and developmental biology of childhood brain tumors. We are seeking a highly motivated and experienced Scientific Manager to assist with the day-to-day management of a sizable laboratory of trainees and technical staff conducting basic and translational research projects with a primary focus on medulloblastoma, the most common malignant childhood brain tumor.
We are seeking for a Research Technologist to focus on translational research support for pediatric solid tumor and brain tumor programs as directed by the DNB Director of Operations and Chair. This position involves assisting with the collection and processing of biological specimens, routine colony maintenance and administration of substances techniques, facilitates specimen inventory and sample shipping worldwide, and maintains detailed records of ongoing scientific projects. Additionally, this person will interact with multiple institutional departments and collaborate on projects and initiatives. Assists with the management of laboratory operations. Performs other related duties as assigned or directed in order to meet the goals and objectives of the department.
*Position will require occasional work after hours, on call and on weekends/holidays (rotational).
We are seeking a highly talented and motivated Bioinformatics Clinical Scientist to join the Department of Pathology at St. Jude Children's Research Hospital. In this role, you will work in multi-disciplinary teams of pathologists, molecular biologists, computational biologists and software engineers to design, develop, validate, implement and continually improve advanced computational pipelines for next generation sequencing (NGS) analysis of tumor and germline data for clinical and translational research applications. You will refine methodologies for data analysis, processing, visualization and storage. You will assist in preparing clinical validation and protocol documents, as well as manuscripts. This is an exciting opportunity to join a dynamic, collaborative group developing cutting edge analytical technologies for high-throughput sequencing and other complex molecular assay data.
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources.
The St. Jude Protein Production Facility provides protein expression and purification services to support the translation of discoveries in molecular and cellular biology to chemical and structural biology. The facility offers state-of-the-art technologies for protein expression/purification from bacterial, insect cell and mammalian systems. The facility has worked with many St. Jude investigators, expressing and purifying almost 2,000 different proteins for use in structural and biochemical characterization, high-throughput screens, and use as reagents or antigens. The facility aims to help investigators obtain pure proteins for biochemical assay and structure determination for the development of new anti-cancer and anti-infective drugs.
Contributing to our mission of finding cures and saving children, the Protein Production Facility at St. Jude Children’s Research Hospital is looking for an experienced researcher to join the facility as a Sr. Research Technologist or Research Laboratory Specialist to provide support and assistance to different departments and investigators at SJCRH.
A Manager of Software Development position is immediately available for a highly motivated candidate to lead the development of St. Jude’s groundbreaking data sharing ecosystem, St. Jude Cloud. This people leader will direct a team of engineers developing the data sharing ecosystem underpinning the world’s largest repository of pediatric cancer genomics data. St. Jude Cloud is comprised of a set of interconnected web applications which share large-scale genomics data, curated genetics data, and many other types of data produced at St. Jude Children’s Research Hospital with a user base ranging from oncologists to bioinformatics research scientists. Learn more by visiting this link
This position requires staying abreast of emerging technologies, platforms, frameworks to ensure St. Jude’s software quality exceeds industry standards. All candidates are expected to be a creative and critical thinker and a quick learner for new domains and technologies. Additionally, all candidates must have a demonstrated track record of excellence in people management or project management for at least one year.
Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics, and Nature Methods. The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management, and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.
The Biostatistician will have a direct impact on the mission of St. Jude Children’s Research Hospital to advance cures for pediatric catastrophic diseases by providing statistical knowledge and expertise to St. Jude researchers conducting clinical and experimental studies. The Department of Biostatistics is a large department with 14 faculty (PhD level) statisticians, 26 master’s level statisticians, 3 postdoctoral fellows, 8 computer scientists, and administrative staff. Master’s level biostatisticians work in teams with a faculty member and sometimes with other biostatisticians to support assigned specific research areas. This approach enables the successful candidate to gain disease-specific knowledge and expertise and to build productive relationships with collaborators across St. Jude.
We are seeking a Research Technologist to join the laboratory of Dr. Taosheng Chen in the department of Chemical Biology & Therapeutics at St. Jude Children's Research Hospital. The Research Technologist will assist in conducting experiments and analyzing data using techniques such as cell culture, Western blotting, chromatin immunoprecipitation, PCR, qPCR, protein purification, and microplate-based assays. Experience with one or more techniques is preferred, but not required. The work will be performed in a highly collaborative environment with communication among multiple teams, so excellent communication and organizational skills are required. Experience with programs such as Excel, Word, and PowerPoint is also a plus. Opportunity to co-author peer-reviewed publications.
St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.
The Department of Computational Biology is seeking a highly motivated Bioinformatics Research Scientist to develop innovative solutions for visualizing massive and complex cancer genomics data. The candidate will work with the Data Visualization team that is developing many cutting-edge visualization features for the cancer genomics research. The candidate will be responsible for solving technical and scientific challenges in adapting the visualizations in high-profile and mission-critical applications. This includes St. Jude Cloud Visualization Community, Clinical Genomics initiative, NCI Genomics Data Common Portal, among other internal and external collaborative research projects. The candidate will ensure the highly effective and accessible end results of these visualization products, as well as the scientific accuracy and robustness.
Candidates with a strong background in DNA/RNA/epigenome sequencing data analysis, and visualization tool development are highly encouraged to apply for this position. Successful candidates will have excellent critical thinking, data management and programming skills.
Recognized as a world leader in pediatric cancer genomics, the Zhang Lab has developed state-of-art computational algorithms, well-established analytical pipelines, and deep data analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, Nature Genetics and Nature Methods. The lab provides a highly interactive environment with projects involving basic and clinical research collaborators, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.
The role of Supervisor- ARC Research Services contributes to developing treatments for diseases and new methods of diagnosis that fall in line with the St. Jude Children's Research Hospital's mission statement "Finding Cures. Saving Lives." This role will directly supervise the operations and staff of the ARC Research Services Unit of the Animal Resource Center. In addition to ensuring quality assurance of work produced by direct reports and research services staff,the ideal candidate must possess the mastery of time management and multi-tasking. Familiarity with Six Sigma Lean Management Process and database software, preferably with Cayuse Protocol Management software and Breeding Colony Management Software, are highly desired.
Work Schedule: 7:00 am/8:00 am until 3:30 pm/4:30 pm; Required on call rotation
A Senior Research Technologist position is available in the laboratory of Dr. Myriam Labelle in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. The laboratory studies the role of the microenvironment in cancer progression and metastasis, with major efforts dedicated to elucidating the molecular mechanisms by which blood platelets, granulocytes, and the extracellular matrix (ECM) cooperate to promote metastasis (Cancer Cell, 20(5):576-90, 2011; PNAS, 111(30):E3053-61, 2014; EMBO J, 38(16):e101302, 2019). We are looking for a highly motivated, responsible and organized individual to carry out experimental research and help maintain efficient laboratory operations. Work in the lab involves a large number of approaches including work with murine models, patient-derived xenografts, tissue culture and in vitro assays, advanced microscopy approaches, molecular biology, and biochemistry.
St Jude Children's Research Hospital offers an outstanding research environment, state-of-the-art scientific resources and facilities, and a community of highly collaborative investigators.
Internationally recognized for our pioneering research and treatment of children with cancer and other catastrophic diseases, St. Jude is ranked among the best pediatric cancer hospitals in the nation. We are the first and only National Cancer Institute- designated Comprehensive Cancer Center devoted only to children. Our culture fosters goodwill and teamwork with a central focus on responsible animal care balanced with research support to a wide variety of laboratory animal species. It is highly desired that the ideal candidate is proficient with database software and familiar with Microsoft Outlook and Teams.
Work Schedule: M-F 7am-3:30pm; Required weekend rotation; Required overtime to complete late service requests and rotating weekends.
The Research Services Unit of the ARC provides multiple technical skills for the advancement of research with a focus on efficiency, dependability, integrity and quality so the research community can further their scientific efforts and as a result, strive to improve the quality of human life. The Technologist is expected to execute in vivo projects from beginning to end as dictated by research needs. Required to work in all areas of the facility and with all species, especially severely immunocompromised study models. It is highly desired that the ideal candidate is proficient with database software and familiar with Microsoft Outlook and Teams.
Work Schedule: M-F 7am-3:30pm; Rotating weekend shifts; overtime required to cover additional service requests and weekend shifts.
The department of Structural Biology at St Jude Children’s Research Hospital is seeking a full-time senior science writer/editor. This is a unique opportunity for a motivated and experienced writer to work in a dynamic environment where important and challenging biological systems are studied using state-of-the-art structural biology, computational and biophysical techniques. The person will lead initiatives to shape scientific communications by the department, working closely with faculty and scientists to write and edit publications and grant proposals and communicate scientific accomplishments. The writer will actively attend scientific meetings and collaboratively organize and plan symposia held by the department on campus. The ideal candidate will have a passion for scientific communication, strong understanding of the scientific and funding landscape, and experience as an editor in a biology-related scientific journal. Competitive salary and benefits are offered.
The Center for Applied Bioinformatics, a bioinformatics shared resource at St Jude Children’s Research Hospital, is looking for an experienced Manager of Bioinformatics Development and Operations, who will oversee both the development of software solutions and hardware configuration to support large scale bioinformatics analyses across a diverse range of HPC and cloud environments. This position ensures the stability, scalability and reproducibility of bioinformatics pipelines, optimizes novel HPC and cloud architectures to power the cutting-edge bioinformatics pipelines ensuring portability of analyses and results. He or she will lead the implementation of best practices for software development of data model driven workflows to reduce the time to delivery of well tested software and works with customers to ensure the final product meets their needs. He or she will promote the inter-department collaboration as a liaison between information technology professionals and academic departments. This position is also responsible for designing and managing workshops, educational seminars, or tutorial sessions to advocate best practices for software development and usage of bioinformatics pipelines. Candidates with knowledge and experiences of bioinformatics software development, management of the operation of a wide variety of bioinformatics pipelines under the HPC or cloud environment, and/or HPC hardware configuration are highly encouraged to apply.
This position is located in Memphis, TN, and relocation assistance is available.
At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.
We are looking for a Senior Research Technologist or Research Lab Specialist to join the department of Bone Marrow Transplant and Cell Therapy where our research strives to perform cutting-edge laboratory and clinical research, particularly in the areas of immunogenetics, cellular therapy, transplant tolerance, immune reconstitution, infection control, and survivorship. We collaborate with faculty members and scientists across the department to provide flow cytometry analysis and interpretation of patient samples. The ideal candidate would have experience in BD FACSDiva Software or any other flow cytometry software experience.
St. Jude Children’s Research Hospital is recognized one of the “Best Places to Work” by Glassdoor and People magazine’s “50 Companies That Care”. Our mission is to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. We look for the best people to join our team and provide world-class facilities, state-of-the-art technologies, and extraordinary support to ensure scientific progress and help accomplishing our mission.
This position designs biological and analytical methods for in-process, release and stability testing of biological products developed and produced in the GMP facility at St. Jude Children’s Research Hospital. Position is responsible for assay development and assay qualification as per FDA and ICH guidelines. Skills sets can include, but are not limited to, cell-based assays, High Performance Liquid Chromatography, capillary electrophoresis, analytical chemistry, molecular biology, and biochemistry. The position requires technology transfer of assays from the laboratories of internal principal investigators and outside entities, and to develop an experimental plan to further develop the method so it can be used for either release or characterization of the products. Ensures method meets the requirement established by the Food and Drug Administration and International Committee on Harmonization guidelines for a fully qualified assay. Assists in the development of in-process assays used to quantitate and characterize the product during the production process. Generates documents, including Standard Operation Procedures (SOPS), qualification protocols and the qualification analytical methods. Ensures the appropriate Quality Control personnel receive training on relevant developed methods.
This position reports directly to the Director of the Center for ExperimentalNeurotherapeutics (CENT). The CENT program is a new program at St. Jude Children's Research Hospital, and the Program Manager is responsible for building and managing the CENT clinical research operations team. The Program Manager is also responsible for providing drug discovery project support for St. Jude collaborations. This includes working with a multi-institutional project team by: (a) directing the development of research projects between external partnerships and internal St. Jude staff (b) maintaining an organized project environment, (c) establishing and tracking project timelines and milestones, and (d) updating the project SharePoint site and associated databases. The Program Manager is responsible for achieving operational objectives as assigned by contributing information and recommendations to strategic plans and reviews; preparing and completing action plans; implementing production, productivity, quality, and customer-service standards; resolving problems; completing audits; identifying trends; determining system improvements; and implementing change for assigned programs or assigned departments. In this role, you will develop, maintain, and coordinate the resources needed to provide support for each project as assigned. You will also ensure compliance with applicable policies, laws, and regulations. Lastly, you will perform other related duties as assigned to meet the goals of the CENT and the institution.
The Neuro-Oncology Division is an integral part of the larger institutional Brain Tumor Program, which is a multidisciplinary team representing pediatric oncology, neuro-oncology, neurosurgery, radiation oncology, neuroradiology, pathology and neuropsychology. The focus of the program is on innovative therapeutic interventions, including new chemotherapeutic agents studied in conjunction with internationally recognized laboratories in clinical pharmacology and molecular biology. The Clinical Research Associate RN II is a registered nurse who operates under general supervision and acts as site Study Coordinator. The selected candidate will serve as a preceptor/mentor to new clinical research staff.
The Kriwacki lab seeks to understand how phase separation drives the condensation of biomolecules to create liquid-like bodies that mediate diverse biological processes. Importantly, aberrant biomolecular condensation is associated with several devastating human diseases, including cancer and neurodegeneration. A new initiative in the laboratory addresses the role of aberrant phase separation by fusion oncoproteins as drivers in cancer (e.g., NUP98 fusions in AML & AEL). We use an integrative approach, involving a combination of cell and molecular biology, biophysical, and live and fixed cell imaging techniques, coupled with computational methods, to determine how phase separation by NUP98 fusion oncoproteins contributes to the formation of aberrant transcription centers that drive aberrant gene expression and transform hematopoietic cells. We seek an analytical and self-motivated researcher to join the team as a Sr Research Technologist.