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At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.  We are seeking a dynamic Director to lead and direct the Cytogenetics Shared Resource (CSR)with advanced molecular cytogenetics experience.  The Director will manage and assist staff in planning, scheduling, and performing cytogenetic analyses and manipulations required to fulfill the Core’s mission. You will maintain extensive knowledge of cytogenetic technologies and emerging applications. In this role you will employ and maintain effective communication with investigators, CSR staff, and other personnel involved in CSR projects and activities.  The Director will advise and interact with faculty and other research staff on the management, design, and technical needs of projects serviced by the CSR. The Director will ensure and oversee operations and quality of reagents and services provided by the CSR, as well as develop annual budgets and recommendations for future capital acquisitions.   The Cytogenetic Shared Resource provides a large diversity of cytogenetic services including standard G band karyotyping, spectral karyotyping, FISH analysis, and FISH probe design and development. A wide range of FISH services are offered including DNA FISH, RNA FISH, and all combinations of RNA FISH, DNA FISH, and immunofluorescence protein staining.  These types of analysis can be performed sequentially on the exact same cells. This allows for direct visualization of not only gene content but also gene expression and protein translation.     Preferred skills and experiences - Thorough understanding of cytogenetic techniques and analysis. - Experience in G-band karyotyping of human and mouse cells. - Experience in performing Fluorescence in situ hybridization (FISH). - Experience in performing Spectral Karyotype (SKY). - Experience in operating and maintaining karyotype/FISH scanner and karyotyping stations - Fully participates in maintaining a positive team environment that is conducive to end-user satisfaction. - Capable problem solver -Applies sensible approaches that reflect an understanding of all relevant factors and demonstrates an anticipation of consequences in arriving at conclusions or decisions. - Demonstrates the adaptability and flexibility to change behaviors and plans to meet rapidly changing/competing job demands. Revises plans to meet changing circumstances. - Follows through in seeing tasks and assignments to conclusion and obtains results. Takes responsibility for actions and plans. - Organizes work and uses time efficiently. Recommends innovative ways of working more efficiently and effectively. - Ability to direct and train other laboratory personnel. - Ability to effectively communicate both verbally and in writing. - Ability to initiate and conduct experiments with no supervision. - Displays leadership qualities and personal actions that demonstrate ethical values, build trust and positively influence decisions and actions of others. - Displays strong organizational and planning skills that allow self and others to effectively achieve goals. Displays strong Interpersonal Skills. Develops and maintains rapport with others. Varies approach with others and demonstrates effective listening skills.  
Job ID
48013
Department
Cytogenetics
Company
St. Jude Children's Research Hospital
Type
Full Time
The Yu Lab in the Department of Computational Biology is seeking outstanding candidates for a leader researcher focused on systems chemical biology and drug discovery. The Yu Lab is focused on developing and applying computational and systems biology approaches to dissect the molecular circuits that drive tumorigenesis, tumor immune-escape and drug resistance, and identifying novel immunotherapy targets, biomarkers and combination therapies (particularly with immunotherapy) for the treatment of pediatric cancers. This lead researcher will lead the efforts of preclinical target validation, compound screening and optimization, and mechanism of action studies. This lead researcher will assist to analyze and integrate high-throughput omics data, at bulk and single-cell levels, including transcriptomic, genomic, epigenomic, functional genomic, chemical genomic and proteomic data to model context-specific cellular/molecular networks and to identify actionable targets, biomarkers or compounds that could be translated into clinic for the development of precision medicine in pediatric cancer. The candidate will work closely with our collaborators in the departments of iTARGETS, Immunology, Chemical Biology, and Oncology for experiment design and data generation, and with our pipeline and visualization teams to explore novel analysis approaches for drug screening, single-cell RNA-Seq, NGS-based RNAi/CRISPR screening, immune-profiling and proteomics data for molecular network inference and target identification.   Candidates with a strong interest in cancer immunotherapy, cancer precision medicine and expertise in chemical biology, oncology, immunology, computational biology, bioinformatics are encouraged to apply. The successful candidate will also have an opportunity to participate in research projects involved in the analysis of the cancer genome, epigenome, transcriptome or proteome. Experience with omics data analysis using R or Python and familiarity with linux/unix is preferred. Experience and knowledge in chemical biology, immunology and/or immuno-oncology is highly desirable. Expertise in systems biology, network biology, parallel computing, web development, visualization and databases is also highly desirable.   The Yu Lab provides a highly interactive environment with projects involving basic and clinical research collaborators, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and teamwork with scientists who have deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. As a member in Yu Lab, you will interact with leaders in cancer and translational research within and outside the institution and at national/international meetings. Innovative research will be supported by the lab’s infrastructure, which includes a wet-lab component. Lab members have considerable flexibility and freedom to develop their research programs.   St. Jude provides a highly interactive and supportive environment for researchers’ career development and has been named to Glassdoor’s Best Places to Work 2018. St. Jude is a top-ranked hospital (#1 for pediatric cancer specialty in the U.S. in 2017) and a world-class basic research institute with 260+ faculty members.  
Job ID
48137
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children's Research Hospital is seeking motivated biostatistics professionals to join our team, and further our life-saving mission.  We have multiple positions available within the Department of Biostatistics.  Successful candidates will be hired into the career level for which they qualify, based on their education and experience.   The Biostatistics Professionals (“Biostatisticians”) at St. Jude will have a direct impact on the mission of St. Jude by providing statistical expertise to researchers conducting clinical and experimental studies. The Department of Biostatistics is a large department with 14 faculty, 26  biostatisticians, 3 postdoctoral fellows, 8 computing professionals, and administrative staff. Biostatisticians work in teams with a faculty member and sometimes with other biostatisticians to support assigned specific research areas. This approach enables them to gain disease-specific knowledge and expertise while also building productive relationships with collaborators across St. Jude.This position may be eligible for the possibility of remote work.    Biostatistician – Cancer Genomics (1 available opening) In addition to general biostatistics background, we are also specifically seeking a  biostatistician specializing in cancer genomics who will enthusiastically advance the research and mission of St. Jude using their cancer genomics base of knowledge. This staff biostatistician will join Dr. Stan Pounds’ team in the Department of Biostatistics working in statistical cancer genomics. The successful applicant will advance scientific understanding of pediatric leukemia and other cancers while building productive relationships with collaborators across St. Jude. The successful applicant for the Cancer Genomics position will - implement scientifically innovative and computationally complex methods in St. Jude’s outstanding high-performance computing environment, - meet with clinicians, laboratory scientists and other research personnel to develop research projects and objectives, - perform parallel computing in St. Jude’s outstanding high-performance computing environment, and - assist with publication of research discoveries. Ideal knowledge, skills and abilities specific for the Cancer Genomics position:  - Mastery of statistical methods and software (particularly R) - Superb verbal and narrative communication skills, including the ability to effectively articulate statistical methodology and results to non-statisticians - Excellent organizational and time management skills - Design and execute multiple computing jobs to complete demanding statistical analyses of large data sets in a timely manner - Advanced understanding of molecular biology   Biostatistician (multiple available openings) Our biostatisticians are responsible for: - Assisting in the analyses of research studies by using appropriate statistical methods and/or mathematical techniques - Meeting with clinicians, scientists and other research personnel to discuss research projects, goals and hypotheses - Providing support for statistical analyses by extracting data and ensuring accurate data files - Using statistical software packages (e.g., SAS and/or R) to write computer programs to analyze data - Preparing memoranda to effectively document data issues, statistical methodology, and analysis results and interpretations, including results in tabular and graphical forms - Assisting investigators with abstract and manuscript development to disseminate research results Duties are performed under the guidance of a faculty member. Ideal knowledge, skills and abilities for biostatisticians:  - Knowledge of statistical methods - Knowledge of statistical software such as SAS and/or R - Strong oral and verbal communication skills, including the ability to effectively communicate statistical methodology and results to non-statisticians - Excellent organizational and time management skills - Ability to manage multiple projects with competing deadlines in a professional manner   Career Levels Candidate may be hired at a career level that best fits her or his individual qualifications.   Statistical Analyst - Master's Degree in biostatistics, applied statistics, or related field. - Prior medical consulting and/or graduate research experience in a biostatistical environment preferred.   Biostatistician  - Master's Degree in biostatistics, applied statistics, or related field. - Minimum of two (2) years of work experience consistent with that expected of the Statistical Analyst position.   Senior Biostatistician  - Master's Degree in biostatistics, applied statistics, or related field. - Minimum of five (5) years of work experience consistent with that expected of the Statistical Analyst position.   Lead Senior Biostatistician - Master's Degree in biostatistics, applied statistics, or related field. - Minimum of eight (8) years of work experience.
Job ID
F1245
Department
Biostatistics
Company
St. Jude Children's Research Hospital
Type
Full Time

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