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We are seeking a highly driven scientist with broad interest in protein kinases, to oversee, organize and coordinate the activities of multiple researchers in a dynamic, comprehensive, inter-disciplinary initiative at the Department of Structural Biology, St. Jude Children's Research Hospital.   The Blue Sky Initiative "Seeing the Invisible in Protein Kinases" is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027, pp 62–63).   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.     We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases. We are looking for an enthusiastic scientist to join this project and take a key organizational role.   This is a high-level staff position, and the Prinicipal Scientist will: - Oversee the activities of over 40 scientists across different teams performing biochemistry, NMR and computational analyses of different kinases. - Organize and integrate the data generated by those teams. - Be the contact point for PIs and team leaders for information on all ongoing projects. - Identify kinases of biological and medical interest as targets - Search and synthesize the relevant literature information on kinase biology as necessary. - Prepare written materials for reports, presentations and publications. - Take a lead on organizing internal and international scientific meetings - Interact with other teams within St. Jude to identify scientific opportunities relevant for the project Furthermore, the ideal candidate should have a track-record of exceptional organizational and problem-solving skills; outstanding communication skills; be able to absorb, synthesize and integrate different types of information; work independently; and thrive on a highly collaborative and fast-moving environment.
Job ID
44542
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Overview:   A Facilities Attendant career at St. Jude means you will be challenged every day to be your best. At St. Jude you'll work with a dynamic team of compassionate and dedicated professionals who will encourage and support your career goals so you can help fulfil our mission. This position will work under direct supervision and provide facility and equipment sanitation, material handling, transportation and other related tasks in accordance with Standard Operating Procedures as directed to meet departmental goals.   Working Schedule: M-F; 7:00-3:30, rotating weekends and holidays, occasional overtime
Job ID
F1306
Department
ARC
Company
St. Jude Children's Research Hospital
We are looking for experienced Biochemists to aid in structural studies of protein kinases. The Lead Researcher will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  Preferred skills and experience: - Expertise in advanced molecular cloning techniques. - Experience generating chimeric recombinant sequences, site-directed mutagenesis, random mutagenesis, codon optimization, and/or gene synthesis is highly desired. - Strong background in protein biochemistry, protein purification (using affinity and traditional chromatographic techniques), and biophysical characterization. - Hands-on experience with instrumentation essential for protein purification and characterization, especially BioRad/AKTA FPLC, SDS PAGE and Western Blot. - Work in an independent manner to perform protein analysis including (but not limited to) CE SDS, ITC, SPR, U/HPLC, DSF, and cell based functional assays. - Excellent oral, presentation and written communication skills. St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
Job ID
44545
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Giedre Krenciute's Group in the Bone Marrow Transplant Department and Comprehensive Cancer Center and M. Madan Babu's Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biology is seeking a computational biologist to join our team as a Lead Bioinformatics Analyst in our efforts to engineer and improve CAR T cells. The successful candidate will have a strong expertise in computational protein engineering, protein folding and structural bioinformatics, with a keen interest in tackling new challenges at the interface between precision medicine, molecular/cell biology, and computational biology. The candidate will be expected to build structural models of chimeric T cell receptors, assess their quality, perform molecular dynamics (MD) simulations to evaluate and rank the predicted models and to set-up machine-learning pipelines to predict constructs of chimeric T cell receptors that are likely to fold/aggregate. They will be involved in the end-to-end computational analysis, including sequence data pre-processing, ML modelling, structural analysis and performing MD simulations at different resolutions. The candidate will work in a strongly interdisciplinary team composed of molecular biologists, medical experts, computer scientists and computational biologists. The candidate will be expected to lead the bioinformatics analysis component of the team’s effort in collaborations with members of the Center for Data Driven Discovery and Bone Marrow Transplant Department at St. Jude Children’s Research Hospital. When submitting your application, please include your CVand a cover letter.   Dr Krenciute’s group works on highly translational immunology research, with a focus on brain tumors. They use genetically engineered human or murine T cells to design novel, long-lasting and safe therapeutic approaches for pediatric brain tumors. Dr. Krenciute’s Lab studies T cell intrinsic and extrinsic regulators that mediate engineered T cell function in the brain tumor milieu. They also work on engineering and optimizing multi-antigen targeting approaches to overcome antigen escape dilemma.   Dr Babu's group has pioneered data science-based approaches to make biological discoveries and reveal fundamental principles in biological systems. His group has developed state-of-the-art computational and machine learning-based methods to interrogate large-scale biological data from diverse organisms. Dr. Babu’s group investigates biological systems at different scales of complexity: from systems at the atomic level (e.g., structures) to the network of interactions between molecules (e.g., protein interaction–networks) to the level of an entire population (e.g., variation in the human population and cancer genomes).   Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.   St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Krenciute and Babu Groups strive to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide. St Jude offers a well-defined career ladder with potential for growth and advancement. Industry-competitive salaries are based on your degree and years of experience.   
Job ID
46328
Department
Cancer Center Administration
Company
St. Jude Children's Research Hospital
Type
Full Time
The Children's GMP_LLC has multiple vacancies for Sr. Scientist I GMP Manufacturing. We are looking for experienced professionals with ability to work in an independent fashion with minimal daily supervision on the manufacturing of biological products, including monoclonal antibodies, recombinant proteins, gene therapy vectors (Adeno-associated virus and Lentivirus), and live viral vaccines for Phase I and II human clinical trials at St. Jude Children's Research Hospital.The Sr. Scientist I will have appropriate scientific expertise and understanding of the regulations governing the production of biopharmaceuticals as mandated by the United States Food and Drug Administration (FDA), European Medicines Agency (EMA) and the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). Manufacturing processes will meet the requirements for drug substance and drug products as mandated by the Food and Drug Administration.
Job ID
46458
Department
Childrens GMP_LLC
Company
St. Jude Children's Research Hospital
Type
Full Time
If you would like to pursue a role where you can work with murine models and are interested in scientific research, then this Husbandry Technician- I position is for you!  This position contributes to developing treatments  for diseases and new methods of diagnosis that fall in line with the St. Jude Children's Research Hospital's mission statement "Finding Cures. Saving Lives."    Much of the responsibilities for the Husbandry Technician -I  will involve routine tasks essential to the care and welfare of murine models, including: - Operating under close supervision and maintaining  regular, non-specialized murine model housing areas in a neat and orderly manner - Performing regularly scheduled cage changing in non-specialized murine model housing areas - Maintaining adequate food and water supplies for murine model cages - Maintaining proper murine model identification and records - Recognizing and documenting basic murine model health problems as appropriate; fulfilling murine model health program requirements by collecting and submitting biological samples to diagnostic lab Work schedule: M-F, 7:00-3:30; rotating weekends and holidays; occasional overtime
Job ID
44898
Department
ARC
Company
St. Jude Children's Research Hospital
Type
Full Time
The Zebley laboratory within the Department of Bone Marrow Transplantation and Cellular Therapy at St. Jude Children’s Research Hospital is seeking to hire a dedicated Senior Researcher. As part of a larger team of scientists within the Youngblood lab in the Department of Immunology, our lab is dedicated to groundbreaking CD8 T cell research focused on the epigenetic regulation of T cell functions and applying basic science findings toward the advancement of immunotherapy.   This individual will have opportunities to be involved in projects related to the epigenetic enhancement of human T cell-based cellular therapy approaches for clinical trials. Candidates with experience in tissue culture, flow cytometry, in vivo murine work, DNA extraction/bisulfite conversion, single cell and next generation sequencing, and other basic molecular biology techniques are highly encouraged to apply.
Job ID
46370
Department
Bone Marrow Transplant & Cell Therapy
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking for a Researcher to join Dr. Dyer’s laboratory and provide highly technical animal  and research support for members of the laboratory. Dr. Dyer’s research focus on how to improve immunotherapy for patients with Neuroblastoma, in addition to elucidate retinoblastoma cellular origins and develop more effective, targeted therapy.  St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for childhood disease. St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and was one of The Scientist’s top 10 “Best Places to Work in Academia” for seven consecutive years. St. Jude offers highly competitive stipends and benefits and actively fosters professional development.   Please include a cover letter in your application addressed to Dr. Michael Dyer. Application Tips  
Job ID
46468
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for multiple experienced biochemists to aid in structural studies of protein kinases. The biochemists will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab(Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  Preferred skills and experiences - Experience with molecular biology and molecular cloning techniques including subcloning, site-directed mutagenesis, PCR and DNA manipulation is desired. - Experience with a variety of protein expression platforms, including E. coli, insect cell culture and mammalian expression systems. - Expert in protein purification by various chromatographic techniques including but not limited to IMAC, IEC, HIC, SEC etc. - Experience with protein engineering or rational design of recombinant proteins along with characterization techniques (for example MS, SEC-MALs, DSF, DLS, SDS-Page etc.). - Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals. -  Outstanding organizational and multi-tasking skills; able to manage several projects going simultaneously. -  Maintain familiarity with current scientific literature relevant to the research experiments or project. -  An excellent team-player with strong communication skills and a willingness to mentor others. St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.  
Job ID
44582
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine.   St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients. The Department of Structural Biology is seeking a synthetic organic chemist to lead chemistry initiatives in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also lead chemical biology initiatives aimed at advancing the mechanistic study of clinically important biological systems at the single-molecule scale. The highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.   Preferred Skills - Experience designing and performing multiple-step synthesis from commercially available reagents. - Experience in troubleshooting and optimizing chemical reactions and purification techniques. - Experience with moisture-sensitive reactants, conventional chromatographic methods, HPLC purification, LC-MS, and NMR. - Basic knowledge in fluorophore design and good understanding in fluorophore structure -performance relationships. - Ability to carry out multiple projects and responsibilities in parallel, delegating as appropriate. - Expert ability to distill complex information in a clear and concise manner both verbally and in writing.
Job ID
44514
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we provide state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment. The Margolis lab in the Infectious Diseases Department is seeking a Scientist to join their interdisciplinary and highly collaborative team of microbiologists,computational biologists and clinicians. The research focus of the lab is to advance understanding of the bacterial community and host-bacterial interactions which contribute to antibiotic resistance and alter treatment outcomes in immunocompromised pediatric patients. This position will lead laboratory-based projects to elucidate the normal physiological and immunological functions of pediatric microbial communities and evaluate microbial colonization resistance mechanisms to multi-drug resistant bacteria.   In this role, you will join a laboratory, where we endeavor to move smoothly between large human data sets and in vivo and in vitro model systems to gain a deeper functional understanding of the pediatric microbiota, host and bacterial interactions and response to cancer/antibiotic treatment. The ideal candidate will have a strong background in microbiology, immunology, metagenomics, evolutionary biology, metabolomics and/or microbial ecology.    Preferred experiences (one or more of) - Anerobic microbial cultivation - Primary and stem cell culture - Host-microbiome interactions - Identification of microbial taxa or metabolites - Animal infection models  
Job ID
44493
Department
Infectious Diseases
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking for a Researcher to join Dr. Dyer’s laboratory and provide highly technical animal  and research support for members of the laboratory.  Dr. Dyer’s research focus on how to improve immunotherapy for patients with Neuroblastoma, in addition to elucidate retinoblastoma cellular origins and develop more effective, targeted therapy.  St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for childhood disease. St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and was one of The Scientist’s top 10 “Best Places to Work in Academia” for seven consecutive years. St. Jude offers highly competitive stipends and benefits and actively fosters professional development.   Please include a cover letter in your application addressed to Dr. Justina McEyoy. Application Tips  
Job ID
46378
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Therapeutic Production and Quality department is looking for a Sr. Scientist I Process Development to design and implement process development experiments with minimal supervision, both upstream and downstream unit operations. In this role you will perform small scale culture experiments, set up and run bioreactors for culture of mammalian or bacterial cells, and optimize purification methods using various chromatography techniques. Experience in mammalian cell culture, bioreactors, protein purification, tangential flow filtration and various other filtration techniques is preferred. You will generate monoclonal antibodies, recombinant proteins, and gene therapy vectors including Lentiviral and AAV vectors.
Job ID
46445
Department
Therapeutics Production & Quality
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for an outstanding and highly motivated Researcher to help us advance state-of-the-art understanding of genome editing approaches for therapeutics. We are hiring a new team member for our NIH Somatic Cell Genome Editing consortium project, focused on developing a new platform for defining biological adverse consequences of editing in human T cells. We care deeply about the success of our scientists and this is a unique opportunity to learn about genomics while improving confidence in the safety of genome editing therapies.   The Tsai and Cheng labs are collaborative and creative academic lab groups focused on advancing genome editing technologies for therapeutics and understanding the function of non-coding regulatory elements in the human genome, respectively.    You will help a highly collaborative and fast-paced team to advance methods for defining biological consequences of genome editing of human T cells. You will use high-throughput genomic and epigenomic approaches to characterize the activities of CRISPR genome editors (including nucleases, base editors, and prime editors), and help develop and validate a novel platform to functionally interpret these activities. We are highly supportive of candidates who wish to pursue a PhD in the future, and recent lab members in this position have gone on to highly competitive graduate programs.   Please include a cover letter in your application addressed to Dr. Shengdar Tsai. Application Tips  
Job ID
46374
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking an industrious, self-motivated Researcher to join our in vivo imaging and therapeutics team. The Center for In Vivo Imaging and Therapeutics (CIVIT) provides cutting-edge preclinical imaging technology and related services to support research at St. Jude Children’s Research Hospital.  The successful candidate will work with scientists and other research personnel, supporting a wide array of pharmacology and efficacy studies. 
Job ID
46110
Department
Center for In Vivo Imaging & Therapy
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking outstanding, highly motivated, and creative candidates for a Senior or Lead Researcher role in a new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.   You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children's Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.   You will have the opportunity to learn about and support new exciting projects such as: - Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin. - Process development and IND-enabling studies PharmmToxx) Please include a cover letter in your application addressed to Dr. Jonathan Yen.    
Job ID
F1221
Department
Hematology
Company
St. Jude Children's Research Hospital
Seeking a highly motivated, organized, and responsible individual to lead a major component of our new cancer genetics and epigenetics lab, as a foundation for their career advancement in academia or industry. Candidates will leverage cancer genomics and epigenomics data that we have generated in a variety of pediatric and adult brain tumors to undertake experiments in functional discovery, validation, as well as the development of integrated large-scale datasets using new genetic technologies. The ideal candidate will demonstrate a willingness to learn new concepts and technical skills, but most importantly harbor an enthusiasm for working in a team-based environment and interfacing with national and international collaborative efforts.   Qualified candidates will have a strong background in aspects of molecular and cellular biology, developmental and stem cell biology, neurobiology, neuroscience, chromatin biology/epigenetics, and/or cancer biology, substantiated by first author publications in high-impact journals. Direct hands-on experience with in vivo functional studies and/or the biological characterization of gene/protein function are required for this position. In addition, competitive candidates will be proficient with molecular cloning, CRISPR/Cas9 gene editing, recombinant virus preparation and transduction, primary and stem cell culture, iPS cell and/or organoid propagation, and a wide spectrum of molecular, biochemical, and cellular assays. Excellent written and communication skills, ability to effectively collaborate with fellow trainees and scientists, and execute tasks in a timely manner are highly desired.
Job ID
44660
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children's Research Hospital, a staff Biostatistician specializing in cancer genomics will enthusiastically advance the research and mission of St. Jude towards the dream that no child die in the dawn of life. This staff biostatistician will join Dr. Stan Pounds’ team in the Department of Biostatistics working in statistical cancer genomics. The successful applicant will advance scientific understanding of pediatric leukemia and other cancers while building productive relationships with collaborators across St. Jude.   The successful applicant will - implement scientifically innovative and computationally complex methods in St. Jude’s outstanding high-performance computing environment, - meet with clinicians, laboratory scientists and other research personnel to develop research projects and objectives, - perform parallel computing in St. Jude’s outstanding high-performance computing environment, and - assist with publication of research discoveries. Ideal knowledge, skills and abilities:  - Mastery of statistical methods and software (particularly R) - Superb verbal and narrative communication skills, including the ability to effectively articulate statistical methodology and results to non-statisticians - Excellent organizational and time management skills - Design and execute multiple computing jobs to complete demanding statistical analyses of large data sets in a timely manner - Advanced understanding of molecular biology   Candidate may be hired at a career level that best fits her or his individual qualifications.   Statistical Analyst - Master's Degree in biostatistics, applied statistics, or related field. - Prior medical consulting and/or graduate research experience in a biostatistical environment preferred. Biostatistician  - Master's Degree in biostatistics, applied statistics, or related field. - Minimum of two (2) years of work experience consistent with that expected of the Statistical Analyst position. Senior Biostatistician  - Master's Degree in biostatistics, applied statistics, or related field. - Minimum of five (5) years of work experience consistent with that expected of the Statistical Analyst position. Lead Senior Biostatistician - Master's Degree in biostatistics, applied statistics, or related field. - Minimum of eight (8) years of work experience.
Job ID
F1245
Department
Biostatistics
Company
St. Jude Children's Research Hospital
Type
Full Time

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