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During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases. At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.
St Jude Children’s Research Hospital is committed to investing in and implementing cutting-edge imaging technologies to support basic scientific and translational research. An integral part of this infrastructure has been the establishment of our Center for In Vivo Imaging and Therapeutics (CIVIT) a dynamic imaging facility that is home to some of the latest technologies including high-resolution ultrasound, bioluminescence and intravital microscopy. The recent completion of the Inspiration 4 Advanced Research Center provided the opportunity to take bold steps to dramatically enhance our capabilities in preclinical diagnostic imaging through significant investment in high-field MRI and PET including two 9.4T MRI units supported by cryo-coil technology and spectroscopy tools, a PET insert allowing for simultaneous PET and MRI acquisitions and a state-of-the-art PET-CT system. The availability of cutting-edge ancillary equipment supporting all platforms and an energetic, talented and multi-disciplinary staff ensures that the facility expertly supports the research endeavors of the faculty at St. Jude.
The Director of CIVIT is deeply involved in a wide array of basic science and translational research projects, assisting world-renowned investigators in answering their scientific questions as well as pioneering new applications and technology development to keep the facility state-of-the-art. The CIVIT comprises the Surgery & Imaging and Preclinical Diagnostic Imaging teams, each managed by an experienced section lead. The successful applicant will employ and maintain effective communication with investigators and work closely with their team towards optimum planning, scheduling, training for, and implementation of imaging experiments.
This is a dynamic laboratory environment where you will work with researchers involved in innovative basic and translational research for the fulfillment of our mission: Finding Cures. Saving Children.
We have an opportunity for a Scientist or Senior Scientist in the lab of Dr. Charles Roberts in the Department of Oncology at St. Jude Children's Research Hospital.
The Roberts lab studies chromatin-mediated regulation of gene expression. We focus upon the SWI/SNF (BAF) chromatin remodeling/tumor suppressor complex and its relationship to cancers. Genes encoding subunits of the SWI/SNF complex are mutated in over 20% of all cancers making it the most frequently mutated chromatin regulator in human malignancies. We seek to discover the mechanisms by which SWI/SNF complex facilitates regulation of gene expression and lineage specification, and the mechanisms by which mutation of SWI/SNF subunits drives cancer formation. We also seek to identify specific vulnerabilities that are conferred by SWI/SNF mutations with the goal of identifying novel therapeutic opportunities, an area in which we have already been successful.
We seek an ambitious scientist with a strong background in molecular biology, cell biology, cancer biology, and/or genetics/epigenetics of tumorigenesis. Currently there are several projects ongoing in the laboratory involving the use of a variety of model systems that have been engineered in the lab including mouse models, primary cells, and cell lines as well as the use of large sequencing, CRISPR, and drug vulnerability data sets.
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve..
The laboratory of Dr. Mitchell Weiss is seeking a Lead Researcher to join in their group in the Department of Hematology.
Through their innovative research program, we seek to provide outstanding clinical care, and promote education, with the long-term goal of improving the lives of, and ultimately curing children with catastrophic non-malignant blood diseases. The mission of the laboratory is to use integrated genomic, experimental, and preclinical approaches to identify the genetic changes that drive β-Thalassemia and Sickle Cell Disease, to gain mechanistic insight into the roles of these genetic alterations in blood diseases, and to identify and test new therapeutic approaches that consider the unique genetic composition of each patient.
The successful applicant will be experienced and conversant in a range of experimental approaches including animal experimentation and basic biochemical tools. Proficiency in in vivo [mouse] husbandry and manipulation is strongly preferred.
A Senior Researcher position is currently available in the Pharmacotyping Resource, located within the Pharmacy and Pharmaceutical Sciences Department, St. Jude Children’s Research Hospital, Memphis, TN.
The mission of the Pharmacotyping Resource is to leverage new drug screening technology to enable collaborative pharmacogenomics research that will translate into improved cancer treatment outcomes. The resource uses a state-of-the-art fluorescence imaging platform to test drug sensitivity profiles (pharmacotyping) of a variety of pathologic tissues obtained from children with catastrophic diseases, with a focus on pediatric cancer. We seek an accomplished, self-motivated, meticulously organized senior researcher with a strong background in cell culture and microplate assays to work with fluorescence imaging and drug assay development.
Candidates should have experience with cell culture and be able to perform a wide range of laboratory research procedures and conduct complex support tasks and projects determined by our current research. Duties will include molecular and cellular analyses and ex vivo testing of patient tissues using fluorescence imaging methods. The position will involve interaction with other staff scientists, bioinformaticians, and trainees and presentation of scientific findings during regular working group meetings. Candidates should be able to communicate effectively and work both independently and as part of a team.
Experience with handling and processing of primary tissues for cell culture, DNA extraction, microplate assays and fluorescence imaging are strongly preferred. Candidates with excellent communication and organizational skills are encouraged to apply.
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior Biochemist/Biophysicist to design and implement high throughput biochemical/biophysical assays and screens, including developing direct binding assays to quantify compound-protein interaction.
The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 650K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.
Protein Technologies Center (PTC) is seeking an experienced Surface plasmon resonance (SPR) Scientist who will characterize molecular interactions using SPR and other methods to support Structural biology projects.
The candidate is responsible for the operation and maintenance of the SPR instruments; and should independently plan, optimize and execute experiments to measure the kinetic and equilibrium binding constants. S/he will explore, develop, and apply new methods and technologies to understand the protein-ligand interactions. The candidate will be interacting closely with other scientists and investigators and participating in collaborative research towards understanding the cell functionality and mechanism of disease; should also be willing to train postdocs and other staff members on the instruments.
Preferred skills and experience
- Hands-on experience using Biacore (T200 or S200 or 8K) and/or other biosensors and techniques to analyze a variety of molecular interactions.
- Broad knowledge and understanding of the macromolecular structure, protein-ligand interactions, and biophysical properties.
- Demonstrated ability to tackle multiple projects
Come be a part of the Neuroimaging Laboratory in the Department of Developmental Neurobiology. This advanced imaging facility houses two lattice light sheet microscopes, a custom built adaptive optics enabled lattice light sheet microscope, one Gaussian light sheet system for cleared tissue-imaging, and a wide variety of general use instrumentation for fixed and live-cell applications. We collaborate with leading methods developers to build microscopes and advance the frontier of the field, while also operating a robust training program that enables biologists to rapidly utilize the latest technology in their projects.
The Lead Researcher will support integration of microscope technology into investigator-lead projects, and will primarily be responsible for the maintenance and calibration of the instruments in addition to user guidance and training. There will be opportunities to grow within the role with the potential to become more involved with research and development as they familiarize themselves with our instrumentation and processes.
Successful candidates will be intellectually motivated, have the ability to follow standard operating procedures with a high attention to detail, and have either a background in engineering or extensive microscope experience in a related life science or physical science field. Programming experience in Python and/or MatLAB is desirable but not required.
The Halic lab is seeking a self-motivated, experienced Laboratory Operations Manager to join the team.
The Lab Manager is responsible for the overall operations, administration and daily management of the lab. The successful candidate will have exceptional organizational skills and experience in facilitating operational aspects of a research laboratory. In addition to the maintenance of lab operations, they will be actively involved in research, performing experiments and analyzing results.
We seek applicants with excellent verbal and written communication skills, ability to work independently and as member of a team. Extensive experience with biochemical methodology is required.
The Therapeutic Production and Quality department is looking for a Sr. Scientist I Process Development to design and implement process development experiments with minimal supervision, both upstream and downstream unit operations. In this role you will perform small scale culture experiments, set up and run bioreactors for culture of mammalian or bacterial cells, and optimize purification methods using various chromatography techniques. Experience in mammalian and bacterial cell culture, bioreactors, protein purification, plasmid DNA purification, tangential flow filtration and various other filtration techniques is preferred. You will generate purified plasmid DNA and gene therapy vectors including Lentiviral vectors.
We are seeking for a Researcher to focus on translational research support for pediatric solid tumor and brain tumor programs. This position involves assisting with the collection and processing of biological specimens, routine colony maintenance and administration of substances techniques, facilitates specimen inventory and sample shipping worldwide, and maintains detailed records of ongoing scientific projects. Additionally, this person will interact with multiple institutional departments and collaborate on projects and initiatives. Assists with the management of laboratory operations. Performs other related duties as assigned or directed in order to meet the goals and objectives of the department.
*Position will require occasional work after hours, on call and on weekends/holidays (rotational).
St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine.
St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment to improve the lives of patients. The Department of Structural Biology is seeking a synthetic organic chemist to lead chemistry initiatives in Dr. Scott Blanchard’s lab to further develop intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also lead chemical biology initiatives aimed at advancing the mechanistic study of clinically important biological systems at the single-molecule scale. The highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.
- Experience designing and performing multiple-step synthesis from commercially available reagents.
- Experience in troubleshooting and optimizing chemical reactions and purification techniques.
- Experience with moisture-sensitive reactants, conventional chromatographic methods, HPLC purification, LC-MS, and NMR.
- Basic knowledge in fluorophore design and good understanding in fluorophore structure -performance relationships.
- Ability to carry out multiple projects and responsibilities in parallel, delegating as appropriate.
- Expert ability to distill complex information in a clear and concise manner both verbally and in writing.
The Laboratory Services at St. Jude Children's Research Hospital supports St. Jude Principal Investigators and their research teams by providing cleaning and sterilization of numerous items used for experimentation. Laboratory Services strives for constructive communication with laboratory personnel concerning changes, additions or deletions to the services provided.
For this full time role, the Supervisor of laboratory Services should have exceptional organization skills, positive and motivating attitude, problem solving skills to serve staff and customers, and attention to detail.
Schedule: Monday through Friday 8:00 am-4:30 pm. Occasional rotations to 7:30 am-4 pm will be required as needed.
We have an opportunity for a Senior Researcher to work under the guidance of Dr. Lindsay Talbot in theDepartment of Surgeryat St. Jude.
Dr. Talbot’s research involves identifying strategies to improve CAR T-cell therapy against osteosarcoma and other solid tumors and has a specific focus on metastatic disease. This collaborative lab’s work is highly translational as they seek to introduce new CAR-T cell therapies into clinics. The lab functions as an embedded part of the larger Bone Marrow Transplant and Cell Therapy translational laboratory, and therefore the candidate will be extensively supported by technical and postdoctoral researchers in a highly collaborative and collegial team.
The ideal candidate will have the ability to work independently on projects while supporting the rest of the lab’s initiatives, and have experience with tissue culture, transduction, proliferation and migration assays, animal handling, and FLOW Cytometry.
We are seeking a Manager for the Laboratory Services Department at St. Jude Children's Research Hospital. The selected person will be responsible for the overall scope of operations, leadership, direction, and administration and daily management of Laboratory Services. The manager works closely with investigators, lab directors and managers, research staff, clinicians, and hospital administrators to assess service needs and foster productive, working relationships. Under this role, the manager directs activities of Laboratory Services personnel to meet institutional service needs. Prepares capital and operating budgets for the department and is responsible for monthly and annual reporting. Develops and revises Standard Operating Procedures (SOPs) and policies and standards for laboratory processes and quality assurance initiatives. Services provided for research departments include 1) glassware, media, and reagent cleaning and sterilization; 2 pipette calibration and repair; and 3) media broth preparation.
The Tsai labis a collaborative, creative and fun academic lab group at St. Jude Children’s Research Hospital focused on advancing genome editing technologies for therapeutics. We are known for developing state-of-the-art genomic methods to understand and improve genome editors, and translating them for therapeutic applications. Dr. Tsai was chosen as one of the American Society for Gene and Cell Therapy (ASGCT) Outstanding New Investigators in 2020 and is one of the co-chairs of the Steering Committee of the NIH Somatic Cell Genome Editing Consortium.
We areseeking an outstanding, experienced, and highly-motivated Lead Researcher to help us advance state-of-the-art genome editing approaches for Cas12a nucleases. We care deeply about the success of our scientists and this is a unique opportunity to work on understanding a class of novel CRISPR genome editors.
You will work in a highly collaborative and fast-paced team focused on developing state-of-the art approachesto understand the genome-wide off-target activity of genome editors. As a Lead Researcher you will use high-throughput genomic approaches to characterize the safety of Cas12a genome editors, and help generate key data to support the development of novel engineered versions of Cas12a.
Apply nowto join our talented team! Please include your CV and a cover letter addressed to Dr. Tsai who will read and review all qualified applications.
The Tsai lab is a collaborative, creative, and fun academic lab groups at St. Jude Children’s Research Hospital, focused on advancing genome editing technologies for therapeutic treatment of diseases like sickle cell disease and cancer.
We are seeking an outstanding and highly motivated Researcher to help us advance state-of-the-art genome editing approaches for therapeutics by protein engineering of improved editors.
We care deeply about the success of our scientists and this is a unique opportunity to learn about genomics while improving confidence in the safety of genome editing therapies. We are highly supportive of candidates who wish to pursue a PhD in the future, and recent lab members in this position have gone on to highly competitive graduate programs.
Apply now to join our talented team!
Please include your resume and a cover letter addressed to Dr. Tsai who will read and review all qualified applications. If you have questions about the position, please don’t hesitate to e-mail Dr. Tsai (email@example.com).
The department of Chemical Biology and Therapeutics at St Jude Children’s Research Hospital is seeking a full-time science research writer. This is a unique opportunity for a motivated and experienced writer to work in a dynamic environment with state-of-the-art technology at the interface of Chemistry, Biology, and Medicine. The person in this role will work closely with faculty and scientists to write and edit primary research articles and reviews for journal submission and publication; preparation of grants and project proposals and communicate scientific accomplishments of the department.
The successful candidate will have a strong scientific background and experience preferably in chemistry and biology; intellectual curiosity and ability to quickly learn new scientific topics and to keep abreast of the literature in the field; excellent skills in communication, manuscript writing and critical thinking; a keen attention to detail and desire to work in a fast-moving, open scientific environment. Prior editorial experience is highly desirable.
This position may be eligible for the possibility of remote work. Please submit a cover letter.
There is a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve. There is a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers.
About the position
Ideal candidate will have 4+ years of experience in clinical biomedical and/or behavioral research.
The Clinical Research Associate III operates under general supervision and performs activities consistent with those of a Study Coordinator role, namely maintenance of protocol portfolio(s), informed consent(s) and preparation/submission of complex study documents. This position also performs data abstraction, collection, and entry to support clinical research and prepares submission for all reportable events. The selected candidate develops, maintains, and/or monitors case report forms and ensures compliance with prescribed interventions and evaluations of the assigned protocol(s). Provision of data to the collaborating research organization or study sponsor and preparation of complex data reports as well as serving as a mentor and preceptor to staff are also key responsibilities.
About the Department of Radiation Oncology
Known for setting standards in technical delivery of radiotherapy and clinical trials, the Department of Radiation Oncology is a full-service department dedicated to clinical research and treatment of 300 children, adolescents, and young adults each year. With the mission of providing expert and compassionate clinical care, the department is the largest group of experts devoted to pediatric radiation oncology who collectively treat more children than any other cancer center or hospital in the country. The department includes:
- Multidisciplinary team: Pediatric radiation oncologists, physicists, dosimetrists, radiation therapists, registered nurses, nurse practitioners as well as supportive research teams (anesthesia, sedation, social work and child life specialists to name a few).
- World-class resources: This includes the first worldwide installation of detector-based spectral CT and digital PET/CT in a Radiation Oncology Department, state-of-the-art 1.5T and 3T MR scanners (radiotherapy simulators), a dedicated PET/CT and the world’s first proton therapy center with pencil beam scanning technology designated solely for the treatment of pediatric cancer.
- State-of-art facility: The department has 20,000 square feet of clinical space that includes a clinic, treatment planning, therapy, anesthesia and sedation support. There are two linear accelerator systems with image-guidance, a HDR/fluoroscopy suite, and spectral CT and 1.5T MR systems dedicated to treatment planning. The adjacent 25,000 square feet St. Jude Red Frog Events Proton Therapy Center includes two gantry rooms and a fixed beam room; each equipped with high-precision patient positioning, volumetric image-guidance systems, and dedicated scanning nozzles.
This position is based in Memphis, TN; relocation assistance is available. Memphis is a family-friendly metropolitan area that more than a million residents call home. Memphis is recognized for its world-class music, food and hospitality. Cost of living is one of our biggest attractions; in fact, Money listed Memphis as one of the least expensive cities in which to raise a child. Mild winters and beautiful green spaces make the city a magnet for outdoor enthusiasts – there are over 200 miles of bike-friendly lanes with more being added. Forbes recently named Memphis the 4th happiest city in which to work. Why live anywhere else?
Take the first step to join our team by applying now!
The Department of Developmental Neurobiology at St. Jude Children's Research Hospital is seeking a Reseacher to join the lab of Dr. Stephen Mack. In this role, the selected candidate will perform laboratory tasks under direct supervision and is expected to understand underlying concepts of experimental design and to implement these concepts under direct supervision.
We are looking for a motivated Lead Researcher to join the lab of Dr. Russell in the Infectious Diseases Department at St. Jude Children's Research Hospital.
Dr. Russell's lab is interested in identifying molecular mechanisms of infectious diseases caused by emerging influenza viruses and paramyxoviruses, negative-strand RNA virus replication and pathogenesis, and studying viral envelope glycoproteins as targets for novel vaccines and drugs.
This is an opportunity to incorporate disciplines from structural biology to studying infectious diseases in animals, better understand how a virus gains pandemic potential in humans, and be on the forefront of improving vaccines.
Experience in viral pathogenesis and working on animal models is preferred.
Candidates with good communication and organizational skills, are encouraged to apply.