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The Director of Improvement Science Research will undertake an exciting opportunity at St. Jude! The individual will be responsible to develop a vision and strategy to increase scholarly output by faculty and staff engaged in improvement science.  This position is a critical step for St. Jude to become an academic leader in improvement science for children with catastrophic disease. This position will be expected to foster a culture that embraces rigorous improvement science methods at an institutional level. The Director will guide faculty, and staff to ensure that quality improvement initiatives meet the standard for academic peer-review. This standard is met by collaborating with researchers and establishing structure that guarantees the design, methodology, analysis, and quality of scientific writing of improvement science efforts meets or exceeds scientific norms.    We are looking for someone who takes initiative and enjoys building a program from the ground up. The individual will need to be able to effectively communicate to a diverse range of internal customers. The selected candidate will be also able to balance providing strategic vision for the team and able to be hands on supporting customers. If this position sounds exciting to you, we look forward to reviewing your resume and application.
Job ID
44472
Department
Office of Quality/Pt Care Ops
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a Senior Researcher or Lead Researcher to join the lab of Dr. Feng with the data collection and analysis for research projects.  The ideal candidate will have experience with bacteria and in vivo and in vitro cell culture and modeling.  Previous laboratory experience with mouse genetics, autoimmune diseases, and/or cancer immunology is strongly preferred. The candidate will perform these tasks related to the research projects independently, but within specific guidelines which are subject to review by supervisor and/or other research staff.
Job ID
44823
Department
Immunology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Cell & Tissue Imaging Center is St Jude’s institutional imaging facility whose mission is to drive and accelerate the use of advanced imaging technologies across St Jude. As a member of CTIC, you will be part of a dynamic team of PhD-level imaging scientists, each of whom has unique specialties but shares a common interest in applying imaging technology to answer biological questions. The Center emphasizes collaborative, in-depth interactions between staff and users to advance research aimed at curing childhood disease (rather than basic ‘fee-for-service’). The Sr. Scientist will support and enable biophysical studies aimed at measuring the properties of phase separating proteins, the spatiotemporal distribution of second messengers within cells, and the spatial relationships between components of signal transduction cascades, including transcription factors on chromatin.    The ideal candidate can effectively convey expert advice on all aspects of the imaging process, from experimental design through data analysis. Expert advice includes a sufficient breadth of knowledge to ensure that samples are properly prepared before reaching the microscope, that image data collected is suitable for down-stream analyses, and that the assumptions and limitations of analysis methods are fully appreciated. Given this high level of intellectual contribution, co-authorship is encouraged and enabled via minimal recharge requirements. The candidate should be intellectually curious, excited to try new approaches, and naturally stay abreast of new developments in the field via reading and conferences. The candidate will also participate in marketing and educational activities provided by CTIC for the broader St Jude research community.  - Expert knowledge on the theory and practice of quantitative fluorescence imaging or spectroscopic techniques, such as Forster resonance energy transfer (FRET), fluorescence lifetime imaging (FLIM), fluorescence correlation spectroscopy (FCS/ICS), single molecule localization microscopy (SMLM), and single particle tracking (SPT), as evidenced by peer-reviewed publications. - Demonstrated coding ability to automate or refine image data analysis. Experience with ImageJ/FIJI tools desirable. - Hands-on experience with related dyes/stains/probes and sample preparation protocols. - Broad understanding of imaging optics and other imaging modalities. - Ability to communicate complex quantitative concepts to non-specialists in one-on-one and group settings. - Outstanding organizational, record keeping, and multi-tasking skills.
Job ID
44818
Department
Cellular Imaging Shared Resources
Company
St. Jude Children's Research Hospital
Type
Full Time
During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases.  At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.  St. Jude Children Research Hospital ensures that scientific progress is never halted from a lack of resources.  We are building on that success with a comprehensive strategy to expand our mission, including our reach around the world.    St Jude Children’s Research Hospital launched a major new strategic initiative in human stem cell research.  At the foundation of this initiative was the establishment of a new  human stem cell shared resource called the Center for Modeling Pediatric Disease (CMPD) where human stem cells will be produced and differentiated to improve treatment for catastrophic diseases of childhood. A custom built robotic platform will allow the CMPD to reprogram primary cells and perform differentiation assays at a scale that that is unprecedented.  The CMPD is led by Sunita D’Souza and her energetic, talented, multi-disciplinary team who are dedicated to support the research endeavors of the faculty at St. Jude.   The Senior Scientist in the CMPD will lead all stem cell differentiation studies enabling world-renowned investigators to answer their scientific questions.  This will include development and optimization of new stem cell differentiation procedures and implementation of those procedures at scale for high-throughput drug screening and high-content image based screening efforts. The successful applicant will be responsible for managing all aspects of stem cell differentiation and collaborating with faculty and staff on exciting and innovative research projects. Daily responsibilities include working with the director and facility staff to develop new stem cell differentiation assays, optimize and validate existing assays and perform stem cell differentiation for St. Jude investigators. In addition to the leadership role in stem cell differentiation, you are expected to play an integral role in the day to day operations of the laboratory, consulting with researchers to formulate optimal workflows and experimental priorities. The Senior Scientist also designs one-on-one training or education sessions to guide best practices and support productive collaborations across the institution.  You will oversee all work performed, and you are expected to maintain extensive knowledge and expertise in current and emerging stem cell differentiation techniques and the associated protocols. This is a dynamic laboratory environment where you will work with researchers involved in innovative basic and translational research for the fulfillment of our mission: Finding Cures. Saving Children.  
Job ID
46471
Department
Ctr for Modelling Ped Disease
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for an expert scientist in microscopy to assist faculty, postdoctoral researchers, staff, and collaborators in advance microscopy techniques and methodologies, as well as routine maintenance of the instrumentation infrastructure. The Director of Microscopy Operations will consult on the development, evaluation, and performance of studies that support the goals and objectives of the Cell and Molecular Biology department. This person may manage quality control, competency assessment, proficiency testing, regulatory requirements, and instrument maintenance and will serve as a resource to others in advance microscopy techniques and methodologies, including tissue analysis and live cell imaging, FRET, FLIM, FRAP, FCS and TIRF, as well as routine maintenance of the instrumentation infrastructure. Other activities include assessing diverse situations, considering alternatives, and choosing or recommending appropriate courses of action, such as the introduction of new approaches and technologies for new instrumentation to the department. Preparation of manuscripts and grant applications, and presentation of the research at in-house and national meetings.  Scientist at St. Jude Children’s Research Hospital know what they can achieve brightest scientific ideas. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where everyone can see, firsthand, how the science translates into survival for the children we serve. Quite simply, at St. Jude, we encourage you to dream big, and we give scientists and researchers everything needed to be the force behind our cures.  
Job ID
46512
Department
Cell & Molecular Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are recruiting a Structural Biologist to join the efforts in structural determination of protein-ligand complexes and contribute structural biology insights into the mechanism of action of novel chemical probes. The Chen laboratory uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The structural biology efforts are expected to synergize with our chemical biology efforts and enable completion of impactful projects (Lin et al., Nature Comm. 2017; Wang et al., J Am Chem Soc. 2021). The Chen lab provides a unique research environment, in addition to basic research, lab members will learn and gain experience in small molecule drug discovery from target validation, chemical probe discovery and optimization to preclinical mechanistic studies. The Senior or Lead Researcher will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, and technologists.   The successful candidate will have proved experience in expression construct design, molecular cloning, protein expression and purification, optimization of crystallization conditions, crystallization and structural determination of protein-ligand complexes using X-ray crystallography.   Experience in the following areas is a plus: purification and crystallization of nuclear receptors; synchrotron data collection; biophysical assays; in silico modeling of protein-ligand interactions; preparation of manuscripts; along with a strong publication record.
Job ID
46476
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time
The Center for Pediatric Neurological Disease Research (CPNDR) is in search for a Research Operations Manager to manage the core facilities and coordinate the overall daily lab operations.   The successful candidate will have education and knowledge in neuroscience, have initiative, and the ability to work independently. The successful candidate will be expected to run and maintain a state-of-the-art histology and tissue processing core that will serve members of the CPNDR, DNB and associated St. Jude neuroscience investigators. The successful candidate will provide guidance for broad histology and tissue processing methodologies and will serve and help build collaborative relationships across the St Jude neuroscience community. Operational priorities will include ensuring the core is performing at a high level of service and operations and also helping promote the CPNDR to neuroscience Investigators at St. Jude Children's Research Hospital.    
Job ID
44326
Department
Center for Pediatric Neurological Disease Research
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for experienced biochemist to aid in our exciting studies of the protein kinome. Our recent NMR studies of the Abl kinase (Xie et al Science 2020) have shown how the conformational states dynamically populated by a kinases directly regulates function. We have been awarded the largest BlueSky initiative grant to expand such studies to the entire protein kinome. We are looking for experienced biochemist to aid in these efforts. The candidate will work in an exciting environment as the candidate studies large and dynamic protein kinases in close collaboration with NMR spectroscopists and computational biologists.  The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz in the world. The research activity will be supported by the BlueSky initiative.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared resource core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
Job ID
44581
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a highly driven scientist with broad interest in protein kinases, to oversee, organize and coordinate the activities of multiple researchers in a dynamic, comprehensive, inter-disciplinary initiative at the Department of Structural Biology, St. Jude Children's Research Hospital.   The Blue Sky Initiative "Seeing the Invisible in Protein Kinases" is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027, pp 62–63).   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.     We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases. We are looking for an enthusiastic scientist to join this project and take a key organizational role.   This is a high-level staff position, and the Prinicipal Scientist will: - Oversee the activities of over 40 scientists across different teams performing biochemistry, NMR and computational analyses of different kinases. - Organize and integrate the data generated by those teams. - Be the contact point for PIs and team leaders for information on all ongoing projects. - Identify kinases of biological and medical interest as targets - Search and synthesize the relevant literature information on kinase biology as necessary. - Prepare written materials for reports, presentations and publications. - Take a lead on organizing internal and international scientific meetings - Interact with other teams within St. Jude to identify scientific opportunities relevant for the project Furthermore, the ideal candidate should have a track-record of exceptional organizational and problem-solving skills; outstanding communication skills; be able to absorb, synthesize and integrate different types of information; work independently; and thrive on a highly collaborative and fast-moving environment.
Job ID
F1267
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Cell and Tissue Imaging Center at St. Jude Children’s Research Hospital is looking for a talented and driven electron microscopist to join the Center at the Sr. Scientist level.   The electron microscopy facility houses a Thermo Fisher Scientific F20, a Helios FIB/SEM and a Teneo VolumeScope SEM as well as a variety of equipment for sample preparation including Leica tissue processors and ultramicrotomes, equipment for low temperature processing and multiple vacuum evaporators. The facility is funded by the Hospital and is utilized by faculty from across the research departments, providing world class imaging to the investigators at St. Jude. Staff members in the Center collaborate with investigators on a variety of research projects from standard tissue pathologies through three-dimensional imaging projects by electron tomography or volume SEM and have the opportunity to participate in development of techniques and protocols to drive St. Jude’s research forward.   The facility is recruiting an experienced electron microscopist to drive implementation and adaptation of high pressure freezing and freeze substitution techniques in support of implementing array tomography and correlative array tomography approaches as well as other established imaging modalities (TEM, FIB-SEM). Primary responsibilities will be implementing specific and appropriate HPF/FS protocols across a diverse set of sample types (multiple tissue types, organoid culture, primary and immortalized cell culture) as well as involvement in downstream sample preparation (rein embedding, serial ultramicrotomy, immunolabeling) and imaging (TEM, SEM).
Job ID
F1297
Department
Cellular Imaging Shared Res
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Pharmacy and Pharmaceutical Sciences at St. Jude Children's Research Hospital is seeking an Associate Biomedical Modeler to join the lab of Dr. Clinton Stewart. In this role you will perform mathematical modeling and statistical analysis for clinical and laboratory research projects. - Knowledge of contemporary mathematical methodologies applicable to pharmacokinetic (PK) and/or pharmacodynamic (PD) modeling (e.g., non-compartmental and compartmental analysis, population-based analysis, translational approach) is essential. - Familiarity with standard PK/PD modeling and statistical software (e.g., NONMEM, Monolix, R or Matlab) and coding languages is required. - This position is responsible for study design, data handling, conducting modeling and application projects, developing software applications as needed, and for providing direction and training to post-doctoral fellows and graduate students on the projects involving mathematical modeling.
Job ID
46435
Department
Pharmaceutical Sciences
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a highly driven scientist with broad interest in protein kinases, to oversee, organize and coordinate the activities of multiple researchers in a dynamic, comprehensive, inter-disciplinary initiative at the Department of Structural Biology, St. Jude Children's Research Hospital.   The Blue Sky Initiative "Seeing the Invisible in Protein Kinases" is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027, pp 62–63).   The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.     We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases. We are looking for an enthusiastic scientist to join this project and take a key organizational role.   This is a high-level staff position, and the Prinicipal Scientist will: - Oversee the activities of over 40 scientists across different teams performing biochemistry, NMR and computational analyses of different kinases. - Organize and integrate the data generated by those teams. - Be the contact point for PIs and team leaders for information on all ongoing projects. - Identify kinases of biological and medical interest as targets - Search and synthesize the relevant literature information on kinase biology as necessary. - Prepare written materials for reports, presentations and publications. - Take a lead on organizing internal and international scientific meetings - Interact with other teams within St. Jude to identify scientific opportunities relevant for the project Furthermore, the ideal candidate should have a track-record of exceptional organizational and problem-solving skills; outstanding communication skills; be able to absorb, synthesize and integrate different types of information; work independently; and thrive on a highly collaborative and fast-moving environment.
Job ID
F1266
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
This Radiochemist/Scientist in the Department of Diagnostic Imaging—Molecular Imaging Core will participate in the production of radiopharmaceuticals for Positron Emission Tomography (PET).  Duties may include synthesis of analytical standards and radiochemistry precursors and radiolabeling with short half-life positron emitting radionuclides. The Radiochemist will assist the Molecular Imaging Core (MIC) with the implementation of known and novel radiotracers for clinical and preclinical use to support the research of institutional faculty. The Radiochemist assists in managing inventory and documentation, maintains efficient laboratory operations, has attention to detail, and performs other duties as assigned or directed in order to meet the goals and objectives of the MIC and the Diagnostic Imaging Department. We are seeking a radiochemist with a strong synthesis background with great organizational and communication skills to contribute to multiple diverse projects and be an ideal team player in our small, impactful team.   Preferred skills: Experience must include performing multi-step organic syntheses, interpreting analytical data (NMR, MS, IR, UV), carbon-11 and fluorine-18, micro-scale reactions, chromatographic separation methods (HPLC, GC, TLC), and troubleshooting complex automated radiochemistry systems and equipment. Experience performing routine maintenance on small laboratory equipment (HPLC, vacuum pumps, etc.) preferred.  Background in radiometal labeling of peptides and antibodies is a plus. 
Job ID
46480
Department
Diagnostic Imaging
Company
St. Jude Children's Research Hospital
Type
Full Time
A Researcher or Senior Researcher position is available in the laboratory of Dr. Myriam Labelle in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital. The Labelle laboratory studies the role of the microenvironment in cancer progression and metastasis, with major efforts dedicated to elucidating the molecular mechanisms by which blood platelets, granulocytes, and the extracellular matrix (ECM) cooperate to promote metastasis (Labelle et al.,Cancer Cell, 2011; PNAS, 2014). In recent work (Hong et al. EMBO J, 2019), we discovered that WISP1, a factor secreted by tumor cells upon interactions with platelets, promotes metastasis by inducing collagen linearization in tumors. Current studies are conducted leveraging a wide array of model systems and techniques including novel mouse models of metastasis, patient-derived xenografts, in vitro co-culture systems, and advanced microscopy approaches.   We are looking for a highly motivated, responsible and organized individual to carry out experimental research and help maintain efficient laboratory operations. Work in the lab involves a large number of approaches including work with murine models, tissue culture, microscopy, molecular biology, genetics and biochemistry. 
Job ID
F1314
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
St. Jude Children’s Research Hospital is one of the world's premier research and treatment centers for pediatric cancer and childhood diseases. It has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and was one of The Scientist’s top 10 “Best Places to Work in Academia” for 7 consecutive years.   The Department of Radiation Oncology at St. Jude is seeking a creative and highly motivated Medical Imaging Scientist who shares our passion for advancing pediatric cancer treatments to join our research team. Under the supervision and guidance of the principal investigator (faculty member), your role will focus on maximizing the therapeutic ratio in proton therapy through novel analysis and modeling of imaging, radiation dose and clinical outcome data. Your discoveries can directly impact pediatric cancer patients treated at St. Jude and the world.   The main areas of our imaging research include improving proton therapy accuracy, developing adaptive proton therapy, and assessing/predicting tumor and normal tissue response to radiation therapy in clinical trials. You will have access to our state-of-the-art imaging technology, which includes two MRI machines, a PET/CT and Spectral CT, all dedicated solely to our department.
Job ID
43761
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Moldoveanu lab is seeking a highly motivated cryo-EM structural biologist to work on interdisciplinary projects at the interface of integrated structural biology and biochemistry of proteins implicated in programmed cell death.   The successful candidate takes a leadership role in applying cryo-EM analysis in characterization of macromolecular complexes implicated in programmed cell death. He or she is expected to: - perform all aspects of single particle cryo-EM analysis independently, including negative staining, grid freezing, data collection and processing, and model building and refinement  - interpret structures to generate hypothesis for functional investigations - prepare and draft relevant sections of papers and grants - interface with the cryo-EM center in training new lab members The ideal candidate will have an academic record of innovative independent research using cryo-EM (papers in the field), hands-on experience with cryo-EM instrumentation, strong background in computational aspects of cryo-EM analysis, experience with sample manipulation for cryo-EM (e.g. purification, crosslinking), excellent oral, presentation, and written communication skills.   The successful candidate will join a highly collaborative team with expertise in biochemistry and structural biology focused on elucidating mechanisms of cell death signaling in the Department of Structural Biology with access to state-of-the-art cryo-EM instrumentation including Titan Krios, Talos Arctica, and Talos L120C. The Department has outstanding infrastructure and expertise in cryo-EM, X-ray crystallography, NMR spectroscopy, protein technologies, proteomics and metabolomics, and single molecule techniques. St. Jude Children’s Research Hospital is a Fortune 100 Best Company to work for. St. Jude offers highly competitive salary and benefits. We are in Memphis, Tennessee, a city newcomers and natives love to call home. It is friendly, affordable, clean, great for young families, and offers excellent quality of life.  
Job ID
44710
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for an outstanding and motivated Scientist to help us advance state-of-the-art genome editing approaches for treatment of sickle cell disease to clinical trials at St. Jude, and to develop the next generation of novel genomic medicines. We care deeply about the success of our scientists and this is a unique opportunity to work on multiple types of CRISPR genome editors, and to make a difference by helping transform them into potentially curative genetic therapies.   You will help lead a highly collaborative and fast-paced team focused on developing state-of-the art approaches to treat sickle cell disease by genome editing of patient human hematopoietic stem cells. You will use high-throughput genomic and protein engineering approaches to characterize the safety and improve different CRISPR genome editors (including nucleases, base editors, and prime editors), and help generate key data to support our goal of opening a clinical trial in 2022.   We are a fun, collaborative, and creative academic lab group focused on advancing genome editing technologies for therapeutics. We are known for developing state-of-the-art genomic methods to understand and improve genome editors, and translating them for therapeutic applications. Dr. Tsai was chosen as one of the American Society for Gene and Cell Therapy (ASGCT) Outstanding New Investigators in 2020, and is one of the co-chairs of the Steering Committee of the NIH Somatic Cell Genome Editing Consortium. As part of your role, you will have opportunities to attend and present at national and international meetings such as ASGCT, ASH, Keystone Genome Engineering, CSHL Genome Editing, and FASEB Genome Engineering.   *Please include a cover letter with your application that will be reviewed directly by Dr. Tsai.
Job ID
44901
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Computational Biology Genomics Laboratory (CBGL) has an opening for a Senior Researcher in the Core for Genomic and Epigenetic Assays (CGEA). The selected individual for this position will have the opportunity to contribute to the understanding of 3D chromosome architecture, and perform leading edge development of epigenetic assays at the low input and single cell level. Experience performing protocols such as chromatin immunoprecipitation assays for sequencing (ChIP-seq), and conformation assays such as Hi-C, 3C,4C, or Capture C is preferred.The CBGL has a strong publication record in the areas if epigenetics and single cell research. The selected individual will have the opportunity of authorship.  
Job ID
46436
Department
Collaborative Research Program
Company
St. Jude Children's Research Hospital
Type
Full Time
The Kriwacki lab is seeking a Senior Researcher to contribute to ongoing NCI-funded studies of links between phase separation by fusion oncoproteins and oncogenesis.The Senior Researcher will perform molecular biology experiments to prepare large numbers of mammalian cell and bacterial expression vectors for cancer-driving fusion oncoproteins. This will involve gene synthesis, PCR, sub-cloning using Gibson assembly and other methods, DNA sequencing and, finally, tests of protein expression in the relevant cell types. Experience with these methods, as well as with aseptic technique and mammalian cell culture, is highly preferred. The Senior Researcher will also participate in functional analyses of fusion oncoproteins in various mammalian cell types using qPCR, RNA-seq, ChIP-seq/Cut & Run, ATAC-seq and HiC. Experience with these genomic and epigenetic methods is highly desired. Also, excellent quantitative, communication and record keeping skills are highly preferred.  
Job ID
46492
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Overview: There’s a reason St. Jude Children’s Research Hospital is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. At our world-class pediatric research hospital, every one of our professionals share our commitment to make a difference in the lives of the children we serve. There’s a unique bond when you’re part of a team that gives their all to advance the treatments and cures of pediatric catastrophic diseases. The result is a collaborative, positive environment where everyone, regardless of their role, receives the resources, support and encouragement to advance and grow their careers.    About the position Ideal candidate will have 2+ years of experience in clinical biomedical and/or behavioral research.   The Clinical Research Associate II operates under general supervision and performs activities consistent with those of a Study Coordinator role, namely maintenance of protocol portfolio(s), informed consent(s) and preparation/submission of complex study documents. This position also performs data abstraction, collection, and entry to support clinical research and prepares submission for all reportable events. The selected candidate develops, maintains, and/or monitors case report forms and ensures compliance with prescribed interventions and evaluations of the assigned protocol(s). Provision of data to the collaborating research organization or study sponsor and preparation of complex data reports as well as serving as a mentor and preceptor to staff are also key responsibilities.   About the Department of Radiation Oncology Known for setting standards in technical delivery of radiotherapy and clinical trials, the Department of Radiation Oncology is a full-service department dedicated to clinical research and treatment of 300 children, adolescents, and young adults each year. With the mission of providing expert and compassionate clinical care, the department is the largest group of experts devoted to pediatric radiation oncology who collectively treat more children than any other cancer center or hospital in the country. The department includes: -  Multidisciplinary team: Pediatric radiation oncologists, physicists, dosimetrists, radiation therapists, registered nurses, nurse practitioners as well as supportive research teams (anesthesia, sedation,  social work and child life specialists to name a few). -  World-class resources: This includes the first worldwide installation of detector-based spectral CT and digital PET/CT in a Radiation Oncology Department, state-of-the-art 1.5T and 3T MR scanners (radiotherapy simulators), a dedicated PET/CT and the world’s first proton therapy center with pencil beam scanning technology designated solely for the treatment of pediatric cancer. -  State-of-art facility: The department has 20,000 square feet of clinical space that includes a clinic, treatment planning, therapy, anesthesia and sedation support. There are two linear accelerator systems with image-guidance, a HDR/fluoroscopy suite, and spectral CT and 1.5T MR systems dedicated to treatment planning. The adjacent 25,000 square feet St. Jude Red Frog Events Proton Therapy Center includes two gantry rooms and a fixed beam room; each equipped with high-precision patient positioning, volumetric image-guidance systems, and dedicated scanning nozzles. About Memphis This position is based in Memphis, TN; relocation assistance is available. Memphis is a family-friendly metropolitan area that more than a million residents call home. Memphis is recognized for its world-class music, food and hospitality. Cost of living is one of our biggest attractions; in fact, Money listed Memphis as one of the least expensive cities in which to raise a child. Mild winters and beautiful green spaces make the city a magnet for outdoor enthusiasts – there are over 200 miles of bike-friendly lanes with more being added. Forbes recently named Memphis the 4th happiest city in which to work. Why live anywhere else?  
Job ID
43732
Department
Radiation Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time

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