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At St. Jude Children's Research Hospital, we are translating science into survival with scientific breakthroughs that are advancing the fight against childhood cancer and other pediatric illness. The Kanneganti laboratory is seeking a highly motivated and team-oriented Science Research Writer to support the development, submission, and publication of the lab’s research articles and reviews and draft and maintain technical documents.   St. Jude Children's Research Hospital offers a unique environment with clinical and basic science investigators working in close proximity and interacting regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state-of-the-art facilities and learn from investigators at the forefront of their fields, consider joining St. Jude.   The laboratory of Dr. Thirumala-Devi Kannegantiinvestigates signaling pathways involved in innate immunity and cell death with a particular focus on NLRs, inflammasomes, and inflammatory cell death (PANoptosis) and understanding how these pathways connect and impact health and disease. Please see the following articles:   Science Immunology (2022) [Epub ahead of print] Nature (2021) 597(7876):415-9. Cell (2021) 184(1):149-168.e17. Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5.   Successful candidates will have excellent critical thinking, problem-solving and data management skills and a keen attention to detail.
Job ID
48789
Department
Immunology
Company
St. Jude Children's Research Hospital
Type
Full Time
The laboratory of Dr. Anang Shelat within the Department of Chemical Biology is seeking a highly motivated scientist interested in leveraging the power of chemical biology to translate promising small molecule drug candidates into clinical trials for pediatric brain and solid tumors. Our lab employs state-of-the-art cell-based high-throughput and high-content screening technologies, advanced bioinformatics and machine learning approaches, and a unique collection of patient-derived orthotopic xenograft tumor models to: (a) investigate drug molecular mechanism of action, (b) identify drivers of drug resistance and sensitivity, and (c) develop combination strategies that enhance in vivo efficacy while preserving a therapeutic window. The lab is particularly interested in exploiting DNA repair defects, identifying and targeting addiction to anti-apoptotic BH3 proteins, and manipulating epigenetic state to selectively eliminate tumor cells.   The applicant must have a strong background in cancer biology and significant experience with in vivo studies, including basic animal husbandry, tissue procurement and processing, and murine xenografting. You must be comfortable working with 2D and 3D cell culture techniques. You will harness the world class resources available at St. Jude to accelerate research and seek new insights. The successful candidate will work alongside basic scientists, clinicians, and pharmacologists in a project team environment, with the goal of translating research findings into clinical trials for children with cancer.  
Job ID
47848
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time
Dr. Xinwei Cao is seeking a Scientist/Lead Researcher for her lab in the Department of Developmental Neurobiology at St. Jude Children’s Research Hospital.   The Cao lab studies the molecular and cellular mechanisms that regulate the development of the vertebrate nervous system, with a special focus on the fundamental mechanisms governing the properties and functions of neural stem/progenitor cells. The Cao lab also investigates the molecular mechanisms and biological relevance of hypertranscription, a poorly understood phenomenon that involves a coordinated increase in the expression of the majority of the transcriptome.      As one of the premier pediatric diseases research institutes in the world, St. Jude Children’s Research Hospital provides exceptional resources and a supportive environment for career development.   Competitive candidates should have a strong background in developmental biology and molecular biology and experience in molecular, cellular, biochemical, imaging, and/or computational techniques. Recent publication in relevant journals is required.
Job ID
48047
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking an outstanding and highly motivated Senior Researcher to join the laboratory of Dr. Mitchell Weiss, chair of the Department of Hematology at St. Jude Children’s Research Hospital.   The Weiss lab is particularly interested in non-malignant disorders of the hematopoietic system including β-thalassemia and sickle cell disease. Our research involves defining the mechanisms of gene regulation during hematopoiesis, the functions of non-coding RNAs, and the mechanisms of protein quality control such as autophagy and ubiquitin-mediated proteolysis in red blood cell formation and associated diseases. Moreover, we are developing novel genome editing based strategies to explore new therapies for β-thalassemia and sickle cell disease using Cas9 genome editing, base editing and other technologies.     We care deeply about the success of our lab members. We are also highly supportive of candidates who wish to pursue a PhD in the future.During his career at Harvard, University of Pennsylvania and St. Jude Children’s Research Hospital, Dr. Weiss has trained numerous students and post-doctoral fellows, most of who have gone on to successful careers in academia or industry.   The successful applicant will be experienced and conversant in a range of experimental approaches including mammalian cell cultures, animal experimentation and basic biochemical tools. Proficiency in in vivo [mouse] husbandry and manipulation is strongly preferred but not required.   Please include your CV and a cover letter (no more than 2 pages) If you have questions about the position, please do not hesitate to email Dr. Christakopoulos (gchrista@stjude.org) or Dr. Weiss (mitch.weiss@stjude.org).
Job ID
F1412
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Blanchard laboratory in the Department of Structural Biology at St. Jude Children’s Research Hospital is seeking a highly motivated Lead Researcher with experience in molecular biology, biochemistry and quantitative biophysical techniques. Our highly interdisciplinary, collaborative, mission-driven environment requires a creative team-oriented individual with strong leadership skills, who would ensure quality operations and our vision to successfully pursue scientific advances.     In this role, the successful candidate will use protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Expert ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing is essential, as well as passion to learn and navigate new research fields.
Job ID
48591
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Our world-renowned Developmental Neurobiology department has an exciting employment opportunity for a Director of Behavior Core. In this role, you will have exposure to breakthrough behavior techniques and technologies, pertaining to modeling of neuropsychiatric diseases. This will involve conventional rodent behaviors combined with optogenetics, chemogenetics, telemetry, fiber photometry, and other state-of-the-art tools. Furthermore, the candidate will work closely with the departmental Neuroimaging Analysis Core, which assists in implementing machine learning for unbiased analysis of rodent behavior.   In this role, a candidate will be responsible for all aspects of rodent behavioral assays, including study design, programming software platforms, analyzing and interpreting data. This job will be specifically focused on developing, characterizing and validating standard and innovative behavioral studies. Previous extensive experience in rodent animal behavior models is required. Experience with behavioral software platforms such as MED-Associates and Clever Sys is highly preferred. The job requires adherence to quality control measures and scientific rigor for ensuring experimental consistency. Contributes to the scientific direction of the laboratory in partnership with Principal Investigator. Manages budget planning process. Provides direction and supervision to laboratory staff. Expected to maintain extensive knowledge and expertise in respective discipline. Responsible for the demands of multiple concurrent projects performed at the core in collaboration with our diverse faculty. Flexible work hours (including some weekends) will be required.  
Job ID
48640
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude Children’s Research Hospital, a NCI designated comprehensive care center, is consistently ranked on Fortune Magazine’s “100 Best Places to Work For” list. Because at our world-class pediatric research hospital, every one of our professionals shares our commitment to make a difference in the lives of the children we serve.   The Human Applications (Cellular Therapy) Laboratory supports the Department of Bone Marrow Transplantation and Cellular Therapy by providing products for patients enrolled in investigator-initiated clinical research protocols. The laboratory supports many treatment trials for cancer and genetic diseases, using primary hematopoietic graft products and genetically modified products for sickle cell disease and CAR T-Cell therapy applications. The Human Applications Laboratory is composed of two sections, the Quality Control Section providing product analysis by flow cytometry and product quality testing for sterility, and the Stem Cell Processing Section providing cellular therapy product processing in accordance with good tissue practices and good manufacturing practices.     Contributing to our mission of finding cures and saving children, we are looking for an enthusiastic and dedicated professional to join the Stem Cell Processing Section as a Specialist I. The successful candidate will be responsible for performing complex, highly specialized technical processing procedures, using aseptic technique and maintaining attention to detail for technical and documentation functions.Cellular therapy processing experience is preferred. Essential computer skills, such as Word, Excel and Outlook as well as flexibility, teamwork, and good communication skills are required for this position. Additional requirements: Ability to work in teams and effectively communicate transitions in work processes. Excellent mathematical skill, analytical skill, and technical dexterity. Ability to function in a cleanroom environment and sustain prolonged physical exertion. Routine schedule is Monday through Friday with flexibility in shift hours as needed for processing procedures. (Rotates On-Call Coverage approximately every 6 weeks.)
Job ID
48717
Department
Human Applications Lab
Company
St. Jude Children's Research Hospital
Type
Full Time
The Velasquez laboratory in the Bone Marrow Transplant and Cellular Therapy Department is looking for a driven and creative scientist/lead researcher to join the team. We develop cell-based immunotherapies for high-risk leukemias with a strong focus on antigen discovery, bispecific CAR design and studying mechanistic implications of CAR T cell therapies. Our group provides a supportive environment, surrounded by an enthusiastic group of researchers and access to top-of the line resources.   This exciting opportunity will allow you to become part of a collaborative environment and develop and characterize novel immune-based therapies in project with high potential for translation into clinical trials.    Preferred skills: - The applicant must be able to conduct independent research in molecular biology, immunology and/or cellular therapy - Experience in molecular assays and tissue culture techniques.  - Experience performing multicolor flow cytometry  - Experience conducting in vivo experiments is highly desirable.  - Ability to communicate effectively - Excellent multi-tasking skills - Ability to work as part of a team - Eager to learn and implement new techniques. In addition to performing independent research, the applicant will also collaborate with other laboratory members on other endeavors.
Job ID
48243
Department
Bone Marrow Trans & Cell Thrpy
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.   This is an exciting opportunity for a researcher to join our Center for Advanced Genome Engineering (CAGE). The Shondra Pruett-Miller laboratory offers a strong team-based environment where you will work collaboratively with other investigators across the institution to support their research needs and develop and improve genome engineering technologies. As a member of our laboratory, you will also bring in cutting edge protocols to provide newer and better workflows to our genome engineering operations.   Successful candidates should display competencies in the following areas: - Understanding of and experience with molecular biology - Extensive experience with cell culture (experience with iPSC, ESC, of HSCs a plus) - Excellent verbal and written communication skills - Excellent multi-tasking skills - Ability to work as part of a team
Job ID
F1393
Department
Cell and Molecular Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The role of Supervisor- Animal Services contributes to developing treatments for diseases and new methods of diagnosis that fall in line with the St. Jude Children's Research Hospital's mission statement "Finding Cures. Saving Lives."  This role will directly provide supervisory and ancillary support within husbandry operations as well as other related duties assigned to meet the goals and objectives of the Animal Resource Center.     Work Schedule: Monday - Friday 7:00 am until 3:30 pm; Rotating 24 hour on-call weekend and holiday duty.
Job ID
48407
Department
ARC
Company
St. Jude Children's Research Hospital
Type
Full Time
The Histology and Tissue Processing Core located in the Center for Pediatric Neurological Disease Research (CPNDR) is seeking support staff (at the Researcher/Senior Researcher level). This individual will provide institution-wide service in the Center Without Walls (CWW), a component of the St Jude Pediatric Translational Neuroscience Initiative (PTNI) which fosters collaborative neuroscience research across St. Jude.  The successful applicant will have experience with tissue processing and histology and general knowledge regarding animal physiology/neuroscience is an advantage.  Highly organized candidates with good communication skills are encouraged to apply.
Job ID
48607
Department
Ctr-Ped Neurological Dis Res
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Hematology at St. Jude Children's Research Hospital is seeking a Lead Research for their Induced Pluripotent Stem Celll (IPSC) core facility. The selected candidate will have the opportunity to collaborate across the department on multiple projects through the maintenance, differenciation, charaterization, and validation of IPSC lines. Additional tasks will include expansion banking and quality control, providing support for researchers, collecting and analyzing data.    The successful candidate will be experienced in Molecular Biology techniques and tissue culture, with preference to those with experience in IPSCs. The ability to work efficiently, handle multiple projects, and communicate effectively with people at all levels within an organization will help you be successful in this role.
Job ID
48730
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Bone Marrow Transplantation and Cellular Therapy is looking for a Data Scientist to help further the mission of St. Jude Children's Research Hospital. The Data Scientist role will have a direct impact on analytics needs of the entire BMTCT Program, utilizing state-of-the-art technologies. This position will be responsible for using data to unlock trends and key insights that are critical for the success of BMTCT operations. In this role, you will gain significant domain knowledge across administrative, clinical, research and basic science areas and help them make effective data based decisions. This is an opportunity to assist sPrincipal Investigators, BMT Faculty, clinicians, and Lab Director in developing presentations, charts and graphs to effectively communicate and illustrate results of key-findings, data analysis and data/science models as well as present them to customers including executive leadership teams. 
Job ID
48753
Department
Bone Marrow Trans & Cell Thrpy
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.   Our world-renowned Developmental Neurobiology department has an exciting employment opportunity for a highly motivated Scientist who has a strong background and interest in mechanisms of brain development, neurodevelopmental disorders, or brain tumors to join the lab of Dr.Young-Goo Han.    Recently, we revealed a key pathway that expands neural stem/progenitor cells and promotes the expansion and folding of the neocortex, the center for superior human cognitive abilities, and are now studying underlying molecular and cellular mechanisms and how alterations in such mechanisms lead to neurodevelopmental disorders and brain tumors.     Our lab is highly collaborative and uses diverse complementary approaches including genetically modified animals, pluripotent stem cell culture, brain organoids, genome editing, high resolution imaging, single-cell sequencing, spatial transcriptomics, proteomics, and in utero surgeries. The successful candidates will have strong experience in molecular, biochemical, cellular, and histological analyses of cell culture and animal models.
Job ID
48172
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide-to advance the research and treatment of pediatric cancer and other catastrophic diseases.   St. Jude is anticipating hiring a Scientist or Senior Scientist in the summer months. We are seeking outstanding, highly motivated, and creative candidates for scientist roles in the new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our ongoing therapeutic pipeline is fueled by internal scientific discoveries academic collaborations. Come join TGEn to enGENEer concepts to cures.   You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.   You will have the opportunity to learn about and support new exciting projects such as: - Development and optimization of pre-clinical genome editing strategies to treat hemoglobinopathies and other hematological diseases. - Process development and IND-enabling studies (Pharm/Tox)     Apply today! A cover letter is highly recommended.
Job ID
F1390
Department
Hematology
Company
St. Jude Children's Research Hospital
The Center for Translational Immunology and Immunotherapy, a collaborative effort between the Departments of Immunology and Bone Marrow Transplantation & Cellular Therapy (BMTCT), has recently launched, with a focus on immune monitoring of new clinical trials, efforts to define and exploit productive anti-tumor immune responses, and characterization of immune competence during standard and experimental cancer treatments.     We are seeking a Scientist to join this exciting multidisciplinary effort. As a member of the Thomas Lab, under the supervision of Dr. Jeremy Chase Crawford, your research will support our comprehensive efforts to study anti-tumor immunity and develop novel, immune-based treatments while collaborating with scientists, clinicians, and bioinformaticians across the institution.   In addition to applying cutting-edge techniques (like single-cell and spatial transcriptomics) to patient samples, you will have opportunities to help develop novel molecular and cellular approaches, pushing the boundaries of current laboratory capabilities.     The ideal candidate will be highly motivated and detail-oriented with an interest in immunology and immunotherapy, and have excellent laboratory, data curation, and critical thinking skills.     Experience with flow cytometry, PCR, NGS library preparation, molecular cloning, and cell culture is preferred. Experience with single-cell genomics and/or spatial transcriptomics is beneficial but not required. Excellent communication and organization skills are required, as you will play a major role in coordinating research efforts among various labs within the institution. In addition, the ability to work as a team player and collaborate effectively is essential for this position. 
Job ID
48273
Department
Translational Immuno-Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
A Scientist or Lead Researcher position is currently available in the laboratory of Dr. Paul Northcott (https://www.stjude.org/research/labs/northcott-lab.html) in the Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN. The Northcott lab is internationally recognized for making seminal contributions to the understanding of the genomics and developmental biology of childhood brain tumors. We seek accomplished, self-motivated, efficient, and meticulously organized scientists with a strong background in primary sample processing for cutting edge next-generation sequencing, including single-cell/nuclei and liquid biopsy analyses.   Candidates should be able to perform and coordinate a wide range of laboratory research procedures and conduct complex support tasks and projects determined by our current research. Duties will include molecular, cellular, and biochemical analyses using methods such as single-cell/nuclei sequencing, ATAC-seq, ChIP-seq, CUT&RUN, and sample processing for translational genomic studies. Prior experience with primary tissue handling and FACS analysis are highly desirable. The position will involve interaction with other staff scientists, bioinformaticians, and trainees on large, multidisciplinary projects and presentation of scientific findings during regular working group meetings. Candidates should be able to communicate effectively and work both independently and as part of a team.   Preferred Skills Experience with handling and processing of primary tissues for DNA, RNA, and protein extractions, single-cell/nuclei sequencing, ATAC-seq, ChIP-seq, CUT&RUN, library preparation/QC analysis, and cell sorting by FACS is strongly preferred. Candidates with excellent communication and organizational skills are encouraged to apply.
Job ID
F1395
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a motivated scientist for assay development with special emphasis on flow cytometry and molecular diagnostic laboratory skills. In this role you will provide technical support for global development projects, including flow cytometry panel design, implementation and cross-validation experiments. The selected candidate will be able to develop adapted standard operating procedures for limited resource pathology labs. Experience with molecular diagnostics, including tissue storage, DNA/RNA extraction, library creation preferred. The successful candidate would also be able to provide assistance on small “proof of concept” projects to help decrease major diagnostic discrepancies, increase quality of FFPE samples, and develop low cost tools to aid in diagnosis. Travel required. Foreign language skills preferred. 
Job ID
48660
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
Dr. Tuomanen is seeking a highly motivated Researcher to join her team in the Department of Infectious Diseases at St. Jude Children's Research Hospital. Preferred candidates will have a general understanding of sterile culture techniques, microscopy and performing biological assays with bacteria. Strong candidates should have some experience with molecular microbiology or protein purification. The candidate will be expected to maintain an organized lab notebook, understand and implement experimental design as well as present results on a weekly basis.  The successful candidate will work in close collaboration with the postdoc in the lab on a project related to bacterial responses to antibiotics. Experience in microbiology is highly preferred.
Job ID
48784
Department
Infectious Diseases
Company
St. Jude Children's Research Hospital
Type
Full Time
The Lead Researcher in Vector Production at St. Jude Children's Research Hospital provides technical skills and expertise for vector production. Performs, evaluates and reports test results as outlined in the laboratory’s standard operating procedures. Actively contributes to the efficient and consistent operations within the St. Jude Vector Production and Development Laboratory. Ensures that Quality Control procedures are performed. Develops or assists in revising standard operating procedures as needed. Performs vector production and participates in troubleshooting as needed. Performs all procedures in compliance with current St. Jude policies. Demonstrates consistent ownership and accountability for all activities.     The successful candidate will be experienced in Molecular Biology techniques and tissue culture, the ability to communicate effectively with people at all levels within an organization, and have a high attention to detail.
Job ID
48093
Department
Vector Development
Company
St. Jude Children's Research Hospital
Type
Full Time

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