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Madan Babu's Group and the Center of Excellence for Data-Driven Discovery in the Department of Structural Biologyis seeking a highly driven, full-time experimental Lead Researcher with expertise in GPCR pharmacology. The Babu Group uses data driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families such as GPCRs and Kinases, respectively. The Lead Researcher will design and carry out experiments aimed at understanding mechanisms of G protein-coupled receptor (GPCR) signaling in human physiology and disease to develop novel therapeutic strategies.   Work from our group has revealed insights into signaling mechanisms linking the ligand-binding pocket in receptors (Nature 2013) to activation-dependent conformational changes (Nature 2016), the selective binding of G proteins (Nature 2017), and allosteric activation mechanism of G proteins (Nature 2015). We have demonstrated that GPCR isoforms diversify signaling response in different human tissues (Nature 2020) and that GPCRs are highly variable in the human population, contributing to variable drug response and posing an economic burden on healthcare systems (Cell 2018).     The ideal candidate will be an expert in the development and use of biosensors to perform imaging, high throughput screening, and functional assays of GPCRs in mammalian cells. The candidate should be an inquisitive problem-solver who thrives in a fast-paced research group with diverse expertise.   Responsibilities - Meticulous electronic documentation of experimental observations, procedures, sample organization and results - Development of FRET, BRET and other high throughput assays for functional screens to dissect GPCR signaling - Engineering mammalian cell lines - Cloning of single constructs and libraries using modern assembly techniques - Collaborate with St. Jude’s Protein Technology Center, Center for Advanced Genome Engineering, as well as Cryo-EM, NMRand X-Ray Crystallography Centers - Plan and present research with passion and clarity - Prepare high-quality manuscripts for publication in high-impact journals   Ranked #2 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is the only NCI-designated Comprehensive Cancer Center devoted solely to children, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, will be the new home of the Babu Group and the Center of Excellence for Data Driven Discovery. There are diverse Basic Science, Translational Science and Data Science communities at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology departments, and support from the Center for Applied Bioinformatics.   The Group believes strongly in providing excellent scope for career advancement to the candidate to develop themselves as a future leader in the field. There will be strong support and encouragement for developing mentoring abilities, "outside the box" scientific ideas and acquiring tangential scientific/technical skills. St Jude offers a well-defined career ladder with potential for growth and advancement. Industry-competitive salaries are based on your degree and years of experience.   St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Babu Group strives to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.     Apply to be a part of the mission of St. Jude Children's Research Hospital: to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.
Job ID
48290
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking to hire a PHP/Laravel Developer who is highly motivated and capable of developing cutting-edge web-based applications as part of St. Jude’s groundbreaking platform, St. Jude Cloud. This team member will work on an agile development team alongside team members as well as world-class researchers to devise novel web applications for working with raw and curated genomics data for a user base ranging from oncologists to bioinformatics research scientists.   This position requires being aware of emerging technologies, platforms, frameworks, and bioinformatics web portals to ensure St. Jude Cloud’s web applications exceed industry standards. The successful candidate is experienced with PHP/larvel development and may have light experience in database design and modern back- and front-end technologies such as Node.js/Express, Ruby on Rails, and modern JavaScript frameworks. Experience in Bioinformatics is preferred. The candidate is expected to be a creative and critical thinker and a quick learner for new domains and technologies.   Recognized as a world leader in mapping the genetic landscape of pediatric cancers, the St. Jude department of Computational Biology has developed state-of-art computational infrastructure, well-established analytical pipelines, and deep genomic analysis expertise with a track record of high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics, and Nature Methods.   The department provides a highly interactive environment with collaborative opportunities across basic and clinical departments, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management, and delivery of high-quality results for highly competitive projects. This position is located in Memphis, TN, and relocation assistance is available.   St. Jude Children's Research Hospital is an Equal Opportunity Employer. St. Jude does not discriminate on the basis of race, national origin, sex, genetic information, sexual orientation, gender identity, transgender status, age, religion, disability, veteran's status or disabled veteran's status with respect to employment opportunities. All qualified applicants will be considered for employment. St. Jude engages in affirmative action to increase employment opportunities for minorities, women, veterans and individuals with disabilities. This position may offer the possibility to work remote.    
Job ID
48355
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Bone Marrow Transplantation & Cellular Therapy at St. Jude Children's Research Hospital is looking for a Senior Researcher to work in the departmental Immune Monitoring Core, which supports faculty members and scientists in the Department on translational research projects. In this role you may i) analyze samples from clinical studies that evaluate the safety and efficacy of cell and/or gene therapies or translational research projects, ii) assist in training other laboratory personnel, and iii) perform other duties as assigned or directed in order to meet the goals and objectives of the department. For this institutionally-funded position, the preferred candidate would have experience in molecular biology, cytokine assays, and cell-based immune assay.  The ideal candidate will have experience as a Medical Technologist. Preferred Skills - Proficiency in molecular biology and cell-based immune assays. - Familiarity with qPCR, Sequencing, Luminex assay, Elispot assays. - Experience in processing patient samples (RNA/DNA isolation, PBMC cell purification). 
Job ID
48708
Department
Bone Marrow Trans & Cell Thrpy
Company
St. Jude Children's Research Hospital
Type
Full Time
As a Clinical Research Associate RN II on this team, you will have the unique opportunity to work to improve the quality-of-life of St. Jude patients. The selected candidate will need be very detailed oriented, organized and be able to perform in-depth data abstraction, collection, and entry to support clinical research. The candidate will also ideally be a skilled communicator, as this role also includes working with patients and families enrolled on quality-of-life studies. We are a hard working team who care deeply about our mission, our research, our St. Jude patients and families, and each other as well.
Job ID
48703
Department
Bone Marrow Trans & Cell Thrpy
Company
St. Jude Children's Research Hospital
Type
Full Time
We have an opportunity for a Researcher or Senior Researcher in the Lab of Dr. John Crispino within the Department of Hematology at St. Jude Children's Research Hospital. The selected candidate will collaborate with other members of the lab to collect data for publications, and will manage the inventory and purchasing for the lab. The focus of the Crispino Lab is to understand the mechanisms of normal and abnormal blood cell development. They do this through basic science to inform highly translational efforts.They strive to better understand disease progression and develop strategies for clinical intervention in inherited anemias, leukemia, and myelodysplastic syndromes. Additionally, the lab explores the link between leukemia and Down syndrome.  The successful candidate will have at least two years experience in a molecular biology lab setting and have familiarity with corresponding techniques and tissue culture.Being highly organized and having the ability to collaborate well and communicate effectively with people at all levels within an organization will help you be successful in this role.
Job ID
48679
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Pharmacokinetics Shared Resource (PKSR) is seeking an advanced-level Senior Scientist to conduct experiments/projects independently under overall direction of the director and/or more senior scientists.   The PKSR facilitates and centralizes high-quality competitively funded peer-reviewed clinical pharmacokinetic/pharmacodynamic research in both clinical and pre-clinical models at St. Jude Children's Research Hospital.     The position requires preparation of detailed reports, development of standard operating procedures and diligent documentation skills. Experience in bioanalytical method design, implementation, and validation are essential. A background in (bio) analytical chemistry, chemistry, or biochemistry is preferred. Additional experience with biological assays requiring performance validation and assessment is desirable (e.g., ELISA, cell based assays). Experience with proteomics workflows, peptide mapping and top-down or bottom-up biopharmaceutical analysis is desirable but not required. Performs other duties as assigned or directed in order to meet the goals and objectives of the department.
Job ID
48741
Department
Pharmacy and Pharmaceutical Sciences
Company
St. Jude Children's Research Hospital
Type
Full Time
The Epigenetics Group from the Center for Applied Bioinformatics at St. Jude Children's Research Hospital is looking for a highly motivated and creative Bioinformatics Research Scientist or Lead Bioinformatics Analyst to develop and apply innovative analytical approaches to understand the underlying mechanisms that drive pediatric cancers and other human diseases. Working for all different projects together with different PIs, employee could make a valuable difference not only to science but also to pediatric cancer patient curation and survival.Besides the various analysis tasks, we alsoencourage exploring newly available methods, pipeline development could result in first author, high profile publications, as long as it aligns with our ultimate goal: “Finding cures. Saving children”.     The Center provides a highly interactive environment with collaborative opportunities within the centers including transcriptomics group, genomics group and genetics group and across basic and clinical departments, access to high performance computing clusters, cloud computing environment, novel sequencing platforms such as long reads sequencing technologies, single cell sequencing at both DNA and RNA level and spatial transcriptomics, innovative visualization tools, highly automated analytical pipelines powered by GPU technology and mentorship from scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects. The members of this Center could work on broad areas of bioinformatics and gain valuable experiences. The members of this Center also have the opportunities to publish high profile papers with prominent authorship and file patents for novel biomarker discoveries or novel methods for clinical diagnosis or disease treatment.     Good candidates will have experience building, optimizing analysis pipelines using available softwareor installing pipelines for high-throughput next generation sequence data analysis(such as ChIP-Seq, ATAC-Seq, RNA-Seq, Hi-C/HI-CHIP/CaptureC) under Linux/Unix environment. The successful candidate is expected to have good programming skills in Bash, Python and R. Also understanding basic Epigenetics gene regulation mechanisms (e.g. Histone Modification, Chromatin Accessibility, DNA Methylation, 3D Genome). Experience with deep learning or nextflow is a plus.     
Job ID
F1437
Department
Center for Applied Bioinformatics
Company
St. Jude Children's Research Hospital
Internationally recognized for our pioneering research and treatment of children with cancer and other catastrophic diseases, St. Jude is ranked among the best pediatric cancer hospitals in the nation.  We are the first and only National Cancer Institute- designated Comprehensive Cancer Center devoted only to children. This position contributes to developing treatments  for diseases and new methods of diagnosis that fall in line with the St. Jude Children's Research Hospital's mission statement "Finding Cures. Saving Lives."  In the role of Sr. Biocontainment Technician, with minimal supervision from the supervisor or manager, your responsibilities entail the following: - Provides basic animal husbandry, facility sanitation and basic veterinary assessments, treatments and technical services support to the animal experimentation conducted in the Animal Biosafety Level 2  and 3+ containment facility of the Animal Resource Center - Required to provide the necessary training to the users and ARC technicians on biocontainment practices including entry and exit requirements.  Work Schedule: M-F; 7:00am-3:30pm; rotating weekends and holidays; occasional overtime *This position starts at a minimum of $20.06/hr. and benefits start on your first day of employment for most roles.* 
Job ID
48779
Department
ARC
Company
St. Jude Children's Research Hospital
Type
Full Time
The Geeleher Lab is seeking a Bioinformatics Research Scientist to work on exciting projects related to cancer genomics, pharmacogenomics, and drug repurposing in the St. Jude Department of Computational Biology. One of the premier pediatric research institutions in the world, St. Jude Children’s Research Hospital provides exceptional resources, a collaborative environment, and access to extensive, unique cancer genomics datasets from large-scale research initiatives.   Positions are available in these broad research areas: - Developing machine learning approaches for integration of pre-clinical, clinical genomics and electronic health record data for drug re-purposing and pharmacogenomics of anticancer agents. Identifying targeted therapies for patients with cancer is a central focus at St. Jude, and genome and RNA sequencing of patients’ tumors is now being performed regularly as part of standard-of-care. A major goal of the Geeleher lab is to explore machine learning approaches to prioritize targetable variants and expand the scope of targeted therapeutics. You will explore, optimize and build on emerging informatics techniques, including integrating somatic variation with transcriptomic variation and with protein-protein interaction networks. The Geeleher lab’s wet-lab component provides a platform for validation of computational predictions and discoveries. Successful completion of the project has the potential for a direct positive impact on patient care and high-impact publications. (Projects funded by our NCI R01 award). - Developing computational methods for single-cell RNA-seq and spatial transcriptomics data. Recent advances have allowed the measurement of genome-wide gene expression directly within tissue sections, using a set of technologies referred to as spatial transcriptomics. These tools allow us to dissect tumor heterogeneity in unprecedented detail and will allow us to study the determinants of drug response at a resolution not previously possible. You will develop new computational and statistical methodologies for analyzing and interpreting these data and develop approaches to integrate spatial transcriptomics with matched single-cell RNA-seq data. You will utilize both Visium and MERFISH data, with a primary focus on neuroblastoma. This work will aim to improve our understanding of tumor heterogeneity and yield computational approaches applicable to a broad variety of complex traits and diseases. (Projects funded by our NIGMS R35 award) The Geeleher Lab is recognized for developing innovative computational approaches and has led drug re-purposing efforts, spearheaded publications in Nature, Genome Research, Genome Biology, Journal of the National Cancer Institute (JNCI) and Bioinformatics in the last five years, and is funded by the NIH. St. Jude offers an exceptional research environment, including state-of-the-art high-performance computing facilities, robust analytical pipelines, the latest wet-lab technology, access to outstanding core facilities and scientific expertise in genomics, cancer biology, statistics, and computer science. The Department of Computational Biology is highly interactive with collaborative opportunities across basic and clinical departments and mentorship from faculty-level scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects
Job ID
46447
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
A Principal Bioinformatics Research Scientist position is immediately available in the lab of Dr. Jinghui Zhang, Chair of the Department of Computational Biology, for a highly motivated candidate to lead omics-based investigation on the etiology, response and therapeutic targets of pediatric cancer.   Candidates with a strong background in computational biology, cancer genomics/epigenetics or cancer predisposition are highly encouraged to apply for this position. Successful candidates shall have a well-established track record in cancer genomic/epigenomic research, in-depth experience in data analysis, excellent critical thinking and manuscript preparation. Experience in software development and mentoring for junior staff is highly desirable.   Recognized as a world leader in genomic analysis, the Zhang lab has focused on computational methods development and research investigation involving both the dry-lab analysis and wet-lab validation with high-impact publications in top-tier biomedical journals such as Nature, NEJM, JAMA, Nature Genetics, Nature Methods and Cancer Discovery. The candidate will be leading highly productive research investigation on advancing cures for pediatric cancers. Our lab also has a track record of providing a nurturing environment that enables scientists to further advance their career by deepening and broadening their scientific and technical skills. We provide a highly interactive environment with collaborative opportunities across a broad spectrum of research areas, access to high performance computing clusters, cloud computing environment, innovative visualization tools, highly automated analytical pipelines and mentorship from faculty scientists with deep experience in data analysis, data management and delivery of high-quality results for highly competitive projects.   This position is located in Memphis, TN, and relocation assistance is available.
Job ID
48265
Department
Computational Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
St. Jude is developing a comprehensive effort to study the immune system in cancer patients, with particular applications aimed at developing and refining immunotherapy approaches. For this effort, bioinformatics is critical, and we are actively searching for a highly motivated scientist who will serve as an informatic bridge between the Departments of Immunology and Bone Marrow Transplant & Cellular Therapy. In addition to spanning these two departments, you will be part of the Thomas Lab and will report to the Director of Immunoinformatics. Working alongside other bioinformaticians, clinicians, and staff scientists, you will have numerous opportunities to be involved in cutting-edge immunological research with direct translational applications, including analysis of near real-time data obtained from ongoing clinical trials. This work will in part entail the development, evaluation, and utilization of novel analytical tools related to bulk and single-cell expression and epigenetic analyses, including processes related to data processing, statistical analysis, network analysis, and data visualization; as such, this is a prime opportunity to develop expertise in the burgeoning field of single-cell bioinformatics broadly and in areas of cancer immunotherapy specifically. Experience in R is required, and previous experience analyzing single-cell gene expression data is highly desirable but not required. Experience with general-purpose programming languages (C/C++, JavaScript, or PHP) preferred but not required. Background in molecular biology, cell biology, immunology, and/or cancer biology, wetlab environment, and familiarity with next-generation sequence analysis are highly preferred. Ability to effectively multitask and communicate clearly are both integral to success in this position.  
Job ID
48378
Department
Translational Immuno-Oncology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Cell and Tissue Imaging Center at St. Jude Children’s Research Hospital is looking for a talented and driven electron microscopist to join the Center at the Scientist level.   The electron microscopy facility houses a Thermo Fisher Scientific F20, a Helios FIB/SEM and a Teneo VolumeScope SEM as well as a variety of equipment for sample preparation including Leica tissue processors and ultramicrotomes, equipment for low temperature processing and multiple vacuum evaporators. The facility is funded by the Hospital and is utilized by faculty from across the research departments, providing world class imaging to the investigators at St. Jude. Staff members in the Center collaborate with investigators on a variety of research projects from standard tissue pathologies through three-dimensional imaging projects by electron tomography or volume SEM and have the opportunity to participate in development of techniques and protocols to drive St. Jude’s research forward.     This position requires experience in biological electron microscopy. Skill sets in volume SEM (scanning block face SEM, array tomography, and FIB/SEM) and/or high pressure freezing and freeze substitution are highly desirable. 
Job ID
48744
Department
Cellular Imaging Shared Res
Company
St. Jude Children's Research Hospital
Type
Full Time
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior Cell and Molecular Biologist to design and implement high throughput cell-based phenotypic screens, ranging from focused high-content imaging-based screens, medium-scale genetic loss-of-function siRNA screens, to large-scale automated cytotoxicity screens.     The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 650K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.
Job ID
48742
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time
The Research Services Unit of the ARC provides multiple technical skills for the advancement of research with a focus on efficiency, dependability, integrity and quality so the research community can further their scientific efforts and as a result, strive to improve the quality of human life. The Technologist is expected to execute in vivo projects from beginning to end as dictated by research needs. Required to work in all areas of the facility and with all species, especially severely immunocompromised study models. It is highly desired that the ideal candidate is proficient with database software and familiar with Microsoft Outlook and Teams. *This position starts at a minimum of $20.06/hr. and benefits start on your first day of employment for most roles.*
Job ID
48799
Department
ARC
Company
St. Jude Children's Research Hospital
Type
Full Time
Dr. Tuomanen is seeking a highly motivated Lead Researcher to join her team in the Department of Infectious Diseases at St. Jude Children's Research Hospital. Preferred candidates will be highly motivated with experience in cell culture techniques, especially with culture of brain cells.  They will need skills in harvesting and fractionating cells and performing general assays of protein expression.  A preferred skill would be preparation and staining of organ slices for microscopy. A small amount of animal work may be required.  The candidate will be able to expected to maintain an organized lab notebook, understand and implement experimental design as well as present results on a weekly basis.   The successful candidate will work in close collaboration with the Lab Manager on a project related to embryonic brain development. Experience in microbiology is highly preferred.
Job ID
48723
Department
Infectious Diseases
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children's Research Hospital, we are translating science into survival with scientific breakthroughs that are advancing the fight against childhood cancer and other pediatric illness. The Kanneganti laboratory is seeking a highly motivated and team-oriented Science Research Writer to support the development, submission, and publication of the lab’s research articles and reviews and draft and maintain technical documents.   St. Jude Children's Research Hospital offers a unique environment with clinical and basic science investigators working in close proximity and interacting regularly to translate scientific discoveries into improved therapies for children. If you are a highly motivated individual who wants to work at a world-class institution with state-of-the-art facilities and learn from investigators at the forefront of their fields, consider joining St. Jude.   The laboratory of Dr. Thirumala-Devi Kannegantiinvestigates signaling pathways involved in innate immunity and cell death with a particular focus on NLRs, inflammasomes, and inflammatory cell death (PANoptosis) and understanding how these pathways connect and impact health and disease. Please see the following articles:   Science Immunology (2022) [Epub ahead of print] Nature (2021) 597(7876):415-9. Cell (2021) 184(1):149-168.e17. Cell (2020) 181(3):674-687.e13. Nature (2019) 573(7775):590-4. Nature Microbiology (2019) 4(2):316-27. Cell (2018) 173:1–14. Journal of Experimental Medicine (2018) 215(4):1023-34. Nature (2016) 540:583-7. Science Immunology (2016) 1(2):aag204-5.   Successful candidates will have excellent critical thinking, problem-solving and data management skills and a keen attention to detail.
Job ID
48789
Department
Immunology
Company
St. Jude Children's Research Hospital
Type
Full Time
M. Madan Babu's Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biologyis seeking a highly driven, full-time human geneticist. This post will be part of a newly established Centre for Adipocyte Signaling (ADIPOSIGN) funded by a major grant from the Novo Nordisk Foundation. This position is available immediately with four years of funding. ADIPOSIGN is run by four partners with highly complementary expertise in the fields of adipocyte biology, transcriptional regulation, signal transduction, physiology, and computational systems biology:   Susanne Mandrup, Prof., Dept. Biochemistry and Molecular Biology, SDU, DK Jan-Wilhelm Kornfeld, Prof., Dept. Biochemistry and Molecular Biology, SDU, DK Madan Babu, Member, Dept. of Structural Biology SJCRH, USA Zach Gerhart-Hines, Assoc. Prof., NNF Center for Basic Metabolic Research, University of Copenhagen, DK   The ideal candidate may have extensive expertise and a proven track record in statistical genetics, population genetics, computational analysis of human genetics and large-scale phenotype data and interpreting genome variation data (coding and non-coding variant effects). Your primary role as a computational human geneticist will be to identify, develop, implement and use computational genetics methods to integrate, mine, visualize and analyze multiple large-scale molecular omics and natural variation datasets for hypothesis generation, polygenic risk score calculation, and creation of molecular network models of obesity. You will develop computational pipelines and machine learning approaches to analyse genome sequences in order to quantify obesity risk and predict its effects. When submitting your application, please include a cover letter.   This position requires relocation to Memphis, TN. When possible, it will involve travel for collaborative purposes to Denmark. You will be working in a highly dynamic and collaborative environment, and will be expected to communicate complex informatics principles, methods, analyses and results to scientists from diverse backgrounds in the consortium.Excellent interpersonal and communication skills are a must, as you will interact directly with both Computational Biologists and Experimentalists in a highly interdisciplinary environment.   Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.   Preferred skills and experience: - Experience with GWAS data analysis, QTL, eQTL analysis, and other methods of linking genotype and epigenetics information to phenotype - Experience with development, implementation and application of Polygenic Risk Score estimation for phenotypes - Experience with diverse statistical data analysis approaches (Bayesian and non-Bayesian statistical methods) - Interest and expertise in adipocyte biology, human physiology, or other areas relevant to the study of obesity - Interest or expertise in GPCR signalling, transcription, metabolic pathways, and/or nuclear receptors is desirable - Experience with writing reports, developing web interfaces for data analysis and/or data dissemination. - Experience with developing and maintaining databases (ideally graph databases) - Experience with novel data visualisation methods
Job ID
45020
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Molecular Pathology group of  the Department of Pathology at St. Jude Children’s Research Hospital (SJCRH) is seeking a highly motivated Bioinformatics Research Scientist. This is an opportunity to implement bioinformatics solutions in next generation sequencing (NGS) and maintain large informatics systems under the direction of Molecular Pathology Leaders.   The Molecular Pathology group uses whole-genome sequencing (WGS), whole exome sequencing (WES), whole transcriptome sequencing (RNA-seq) and target-capture NGS testing for oncology and genetic diagnosis for all patients managed at SJCRH. This group provides comprehensive molecular profiling for all cancer types which would assist clinicians in determining disease diagnosis, risk stratification, prognosis, and treatment options, including targeted therapies and eligibility for clinical trials. We are one of very few clinical laboratories in the US who use the most cutting-edge sequencing platforms, WGS and whole transcriptome sequencing, for oncology molecular diagnosis.   The comprehensive genetic tests developed by Molecular Pathology and Computational Biology at SJCRH involve sequencing the genome of the tumor and the matched normal specimen. These germline findings in cancer predisposition genes could have a significant impact in the clinical management of patients and their families.   The Molecular Pathology team provides a highly interactive environment with collaborative opportunities with Computational Biology Department and Center of Applied Bioinformatics at SJCRH, access to high performance pipelines and computing clusters, a cloud computing environment, innovative visualization tools, and mentorship from senior scientists with expertise in data analysis, data management and delivery of high-quality results. This team supports strong teamwork as well as personal career development.
Job ID
48495
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
As a Clinical Research Associate III (Regulatory) in Infectious Diseases, you act as project manager for institutional as well as St. Jude sponsored, multi-center trials, including regulatory, financial, and administrative aspects of the study. For complex, large multi-site and/or multidisciplinary clinical trials, will coordinate all aspects of the study. Responsibilities also include data abstraction, collection, and entry; preparing submissions for all reportable events; maintaining case report forms; and ensuring compliance with prescribed interventions and evaluations of the assigned protocol. You may be asked to prepare reports for various stakeholders on any given study. Take the next step to join our team by applying now!  
Job ID
48623
Department
Infectious Diseases
Company
St. Jude Children's Research Hospital
Type
Full Time
The laboratory of Dr. Anang Shelat within the Department of Chemical Biology is seeking a highly motivated scientist interested in leveraging the power of chemical biology to translate promising small molecule drug candidates into clinical trials for pediatric brain and solid tumors. Our lab employs state-of-the-art cell-based high-throughput and high-content screening technologies, advanced bioinformatics and machine learning approaches, and a unique collection of patient-derived orthotopic xenograft tumor models to: (a) investigate drug molecular mechanism of action, (b) identify drivers of drug resistance and sensitivity, and (c) develop combination strategies that enhance in vivo efficacy while preserving a therapeutic window. The lab is particularly interested in exploiting DNA repair defects, identifying and targeting addiction to anti-apoptotic BH3 proteins, and manipulating epigenetic state to selectively eliminate tumor cells.   The applicant must have a strong background in cancer biology and significant experience with in vivo studies, including basic animal husbandry, tissue procurement and processing, and murine xenografting. You must be comfortable working with 2D and 3D cell culture techniques. You will harness the world class resources available at St. Jude to accelerate research and seek new insights. The successful candidate will work alongside basic scientists, clinicians, and pharmacologists in a project team environment, with the goal of translating research findings into clinical trials for children with cancer.  
Job ID
47848
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time

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