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We are seeking outstanding, highly motivated candidates for scientist roles in the new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.   You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.   You will have the opportunity to learn about and support new exciting projects such as: - Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin. - Process development and IND-enabling studies (Pharm/Tox) Apply today! A cover letter is highly recommended.   Please include a cover letter in your application addressed to Dr. Jonathan Yen.    
Job ID
F1180
Department
Hematology
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, and extraordinary support for your research to ensure scientific progress is never halted from a lack of resources. At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve.   This is an exciting opportunity for a self-motivated scientist to join the Immunology Department at SJCRH in the laboratory of Dr. Thirumala Devi-Kanneganti. Our laboratory extensively employs murine models to understand how the innate immune system recognizes and responds to pathogens and how genetic mutations in innate immunity affect the development of infectious, inflammatory, and autoimmune diseases in humans.  
Job ID
F1196
Department
Immunology
Company
St. Jude Children's Research Hospital
One staff scientist position is immediately available for motivated candidates in Dr. Peng’s group at St. Jude Children’s Research Hospital, a premier center for biomedical investigation located in Memphis, Tennessee, USA. Our group has contributed to the discovery of ubiquitin code and RNA splicing dysfunction in Alzheimer’s disease (AD). The successful applicant will explore AD pathogenesis by diverse molecular, cellular and genetic approaches, as well as mass spectrometry-based proteomics and systems biology tools, using clinical human AD specimens, mouse models, and human iPSC-derived organoids. The overarching aim is to provide novel insights into AD pathogenesis and therapeutic intervention (https://www.stjude.org/peng). Our publication record is available on Google Scholar (200+ publications, 28,000+ citations). St. Jude is a top ranked hospital (#2 for pediatric cancer specialty in U.S. in 2019) and a world-class basic research institute with ~300 faculty members. Staff scientists at St. Jude are provided with very competitive salary in an affordable city. In this position, you will be responsible to design and perform complex in vitro and in vivo experiments, and analyze data independently. Developing new experimental procedures and publishing research results are expected. The job duty also includes training and supervision of lab members on relevant laboratory procedures and techniques.                                         The candidate shall have a Ph.D. degree in genetics, biochemistry, cell biology, neuroscience and related fields and at least 3 years of post-graduate experience with excellent publication record. The title and salary are commensurate with the experience and qualifications of applicants. Please submit CV, three references and a brief statement regarding previous work to Dr. Junmin Peng (junmin.peng@stjude.org), Member (Full Professor) in Departments of Structural Biology and Developmental Neurobiology, Director of Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital.  
Job ID
44382
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are seeking a highly motivated, organized, and responsible individual to work in a core facility generating genetically engineered mouse and rat models for investigators in the Department of Developmental Neurobiology. Direct hands-on experience with mice is required, hands-on experience with rats is preferred.   The ideal candidate will already be proficient in animal and embryo handling, dissection, anesthesia, and micro-surgery. Experience is preferred in the generation of genetically modified animals by micro-injection (both pronuclear and cytoplasmic), and embryo electroporation. A willingness to learn new concepts and technical skills is optimal.   The candidate should exhibit skill in written and oral communication, the ability to effectively collaborate with co-workers and scientists, and the ability to execute tasks in a timely manner are highly desired. Some weekend and holiday work will be required.  
Job ID
44516
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for multiple experienced NMR spectroscopists to study protein kinases. The NMR scientists will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases,” which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab(Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.    Preferred skills and experiences - Extensive experience in applying NMR techniques in characterization of the structure and dynamics of large proteins, including backbone and methyl assignment methodologies - Experience in using both automated and manual methods for assignment of both backbone and methyl groups - Experience in performing characterization of protein dynamics using CEST - Proficient in data processing using NMRPipe - Experienced in NMR structure calculation and refinement - Independently motivated, detail oriented and good problem-solving ability - Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment - Excellent communications skills  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
Job ID
44584
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for a NMR spectroscopists to study protein kinases. The NMR Senior Researcher will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive.
Job ID
44583
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for experienced NMR spectroscopists to study protein kinases. The NMR Lead Researcher will join an inter-disciplinary Blue Sky Initiative on “Seeing the Invisible in Protein Kinases”, which is supported by $35M in institutional funding by St. Jude Children's Research Hospital. The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 2020, 370, eabc2754) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. The unparalleled NMR center at St. Jude includes three 600 MHz, two 700 MHz, four 800 MHz, 850 MHz, and the first 1.1 GHz. We expect this initiative to have a profound impact on the field, transforming our understanding of protein kinases.  Preferred skills and experience: - Experienced in using multidimensional NMR spectroscopy to study proteins including collection and analysis of three-dimensional noesy data. - Experience in using both automated and manual methods for assignment of backbone and methyl groups. - Working knowledge of protein dynamics using CEST. - Experience in data processing using NMRPipe. - Experienced in NMR structure calculation and refinement. - Independently motivated, detail oriented and good problem-solving ability. - Excellent organizational skills, with an ability to embrace change and multi-task in an extremely fast-paced environment. - Excellent communications skills. St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive
Job ID
44681
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
A Lead Researcher position is currently available in the Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, TN, in the laboratory of Dr. Xinwei Cao. The Cao lab studies the molecular and cellular mechanisms that regulate the development of the vertebrate nervous system, with a special focus on neural stem/progenitor cells. We are also interested in the molecular mechanisms and biological relevance of a phenomenon called “hypertranscription”. We use genetically engineered animal models as well as in vitro models and employ an integrated set of molecular, cellular, biochemical, imaging, and computational techniques. We seek accomplished and self-motivated scientists with strong background in developmental biology, cell biology, or gene regulation and extensive experience in biochemical or molecular techniques.  
Job ID
44810
Department
Developmental Neurobiology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Center for Modeling Pediatric Diseases (CMPD) plays a key role in providing that support. As a new initiative at St Jude Children’s Research Hospital (SJCRH), its mission is to serve the research community by delivering high-quality, fully-characterized, patient-derived, pluripotent cells. Our aim is to generate these cells on our fully-automated, state of the art, robotic system. Our methodologies are based on the Nobel Prize winning work of Shinya Yamanaka, which culminated in the ability to create induced pluripotent stem cells (iPSCs) from terminally-differentiated human somatic cells such as skin cells, blood cells and urine cells. These iPSCs permit the derivation of both normal and disease phenotype, patient-matched cell lines, and are therefore key to developing personalized medicine approaches: iPSCs provide a vital tool to study the cellular and molecular mechanisms involved in patient-specific responses to treatments, and in the future will form the basis of creating patient-derived, patient-matched cellular therapeutics. There are opportunities to develop bioinformatics and data analysis skills, including running machine learning pipelines to evaluate microscope images of developing iPSC colonies. Our automation system includes the latest model instruments: Hamilton Vantage; Hamilton LabElite Decapper; Bionex Centrifuge; Cytation 5; Cytomat (500 capacity); KingFisher Flex; F7 robotic arm and a BioStore III Liquid Nitrogen Freezer.   As CMPD establishes our methodologies and implements our automation we seek an exceptional, self-motivated individual with experience in either cell biology with preferred expertise in robotics and automation or someone with a Biomedical or electrical engineering background that enjoys the thrill of working with a multidisciplinary team to create solutions that automates a series of manual cell culture workflows to aid in increasing stem cell reprogramming throughout. The transition from manual to automated workflows requires a highly-organized, methodical, and algorithmic mindset. This role provides an exceptional opportunity to acquire expertise in developing and implementing automation programming routines. Ability to demonstrate attention to detail is key, as is a desire to work in a highly reproducible manner, by close adherence to optimized SOPs. However, an ability to innovate, and determine where evolutions can be made to improve time and cost efficiencies, in coordination with the team, is also highly desirable.   If you are excited by using state-of-the-art instrumentation, if you are able to take a one-off research experiment and optimize it to make it unbreakably reproducible, and would like to do for biology what Henry T Ford did for car manufacturing, then we would like to hear from you!. A very strong desire to learn automation and process development skills are mandatory.    
Job ID
46355
Department
Ctr for Modelling Ped Disease
Company
St. Jude Children's Research Hospital
Type
Full Time
At St. Jude, you will be part of a collaborative, bench-to-bedside environment where you can see firsthand, how your science translates into survival for the children we serve. We are seeking a self-motivated and detail-oriented Scientist to join the laboratory of Dr. Ellison, in the Department of Pathology. Dr. Ellison’s lab is interested in exploring the clinical and molecular features associated with pediatric brain tumors, particularly ependymoma.   Candidates should be able to perform and coordinate a wide range of laboratory research procedures and conduct a spectrum of complex support tasks and projects determined by our current research. Your duties will include molecular, cellular, and biochemical analyses using methods such as ChIP-Seq, ATAC-Seq, Single Cell-Seq, and processing tissue for translational studies. You will also manage murine colonies and perform cranial implants. Candidates should be able to communicate effectively, work independently, and present scientific findings.
Job ID
46413
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
The Department of Global Pediatric Medicine (GPM) is a growing department looking for professionals who are eager to help implement the St. Jude Global mission of training the clinical workforce, developing and strengthening health systems and patient-centered initiatives, and advancing knowledge to sustain continuous improvement through research.     Summary   This position will provide analytic support to program teams in GPM and St Jude Global. Candidates should demonstrate knowledge of Implementation Science methods and applications to improve point of care and patient health outcomes. In addition, candidates should have knowledge of quantitative and qualitative scientific methods including design of data collection instruments and data analysis, using the selected implementation science theory #impsci, model or framework.  Knowledge/experience in quality improvement studies, methodologies and analytic methods will be an added advantage. Some responsibilities will include programming, analysis of data, graphical presentation and reporting of results, interpretation and explanation of statistical techniques used, and making valid inferences. These activities will be executed as appropriate under the guidance of a GPM Faculty Member. The Biostatistician progresses towards working independently with investigators and ideal candidate should have some experience directly communication with investigators.
Job ID
46410
Department
Global Pediatric Medicine
Company
St. Jude Children's Research Hospital
Type
Full Time
Madan Babu's Group and the Core Center for Data-Driven Discovery in the Department of Structural Biology is seeking a highly driven, full-time Mammalian Synthetic Biologist to lead synthetic biology and pooled cloning, functional genomics, and cellular engineering projects related to IDR-Screen. IDR-Screen is an in-house framework to discover functional intrinsically disordered regions (IDRs) of the mammalian proteome through high-throughput screening of defined sequence protein expression libraries. We use Next-Gen Sequencing coupled with traditional and Machine Learning approaches to uncover sequence-function relationships in IDRs. We also use this pipeline to understand the impact of natural and disease variants in select genes for personalized medicine.   The Babu Group uses data driven approaches to understand sequence-function relationships in intrinsically disordered proteins and structure-function relationships in medicinally important structured protein families, respectively.   Recent examples of our work on these topics include: - Ravarani, C. N., Erkina, T. Y., De Baets, G., Dudman, D. C., Erkine, A. M. & Babu, M. M. High-throughput discovery of functional disordered regions: investigation of transactivation domains. Molecular systems biology 14, e8190, (2018). doi:10.15252/msb.20188190. PMID: 29759983 - Marti-Solano, M., Crilly, S. E., Malinverni, D., Munk, C., Harris, M., Pearce, A., Quon, T., Mackenzie, A. E., Wang, X., Peng, J., Tobin, A. B., Ladds, G., Milligan, G., Gloriam, D. E., Puthenveedu, M. A. & Babu, M. M. Combinatorial expression of GPCR isoforms affects signalling and drug responses. Nature 587, 650-656, (2020). doi: 10.1038/s41586-020-2888-2. PMID: 33149304. - Jones, E. M., Lubock, N. B., Venkatakrishnan, A. J., Wang, J., Tseng, A. M., Paggi, J. M., Latorraca, N. R., Cancilla, D., Satyadi, M., Davis, J. E., Babu, M. M., Dror, R. O. & Kosuri, S. Structural and functional characterization of G protein-coupled receptors with deep mutational scanning. Elife 9, (2020). doi:10.7554/eLife.54895. PMID: 33084570  This position is for an experienced Staff Scientist. The ideal candidate will independently design, develop, clone, and run high-throughput, functional genomics screens using FACS and NGS analysis. The candidate should be an inquisitive problem-solver who thrives in a fast-paced research group with diverse expertise. You will lead projects and work as a part of the IDR-Screen team and contribute to many ongoing research projects in the group, lending your library construction skills to protein expression constructs on Structural Biology projects as well. You will be an indispensable member of the Group. In addition to leading research projects and collaborations, you will have opportunities to participate in many ongoing research projects, where your inputs, expertise, and contributions will be valued.   Consistently ranked Top 10 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is the only NCI-designated Comprehensive Cancer Center devoted solely to children, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, will be the new home of the Babu Group and the Center of Excellence for Data Driven Dicsovery. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology departments, and tremendous support from the Center for Applied Bioinformatics.   The Group believes strongly in providing excellent scope for career advancement to the candidate to develop themselves as a future leader in the field. There will be strong support and encouragement for developing mentoring abilities, "outside the box" scientific ideas and acquiring tangential scientific/technical skills. St Jude offers a well-defined career ladder with potential for growth and advancement. Industry-competitive salaries are based on your degree and years of experience.   St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Babu Group strives to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
Job ID
46423
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
Internationally recognized for our pioneering research and treatment of children with cancer and other catastrophic diseases, St. Jude is ranked among the best pediatric cancer hospitals in the nation.  We are the first and only National Cancer Institute- designated Comprehensive Cancer Center devoted only to children. This position contributes to developing treatments  for diseases and new methods of diagnosis that fall in line with the St. Jude Children's Research Hospital's mission statement "Finding Cures. Saving Lives."  In the role of Biocontainment Technician ABSL-2, with minimal supervision from the supervisor of ABSL-2 or designee, your responsibilities entail the following: - Provides basic animal husbandry, facility sanitation and basic technical services support to the animal experimentation conducted in the Animal Biosafety Level 2 containment facility of the Animal Resource Center - Occasional supervised entry into ABSL-3 plus containment facility may be required to fulfill study demands.  Work Schedule: M-F; 7:00am-3:30pm; rotating weekends and holidays; occasional overtime
Job ID
46525
Department
ARC
Company
St. Jude Children's Research Hospital
Type
Full Time
Provides for the daily husbandry and care of rodents, swine, ferrets, avian and aquatic species. Ability to provide back up support in all the areas at short notice. Maintains proper husbandry, environmental and study related records for all species according to standard operating protocols and institutional policies. Recognizes and documents animal health problems as appropriate; assists with drug preparations and basic veterinary treatments, collects and submits biological samples to diagnostic laboratory. Performs daily tasks according to pertinent federal regulations and Assessment and Accreditation of Laboratory Animal Care (AAALAC) standards. Ability to apply knowledge of disinfection, sterilization, sanitation and environmental microbiological analysis while working with different species and biosecurity zones. Maintains a high level of awareness of biosecurity and biosafety levels within the facility.  Work Schedule: M-F; 7:00AM-3:30PM; rotating weekends and holidays; occasional overtime
Job ID
46508
Department
ARC
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for highly motivated structural biologist to work on interdisciplinary projects at the interface of structural biology, biochemistry, biophysics, and molecular biology to study molecular mechanisms of Receptor Tyrosine Kinases (RTKs). The successful candidate takes a leadership role and should be able to independently design and perform complex experiments, analyze data and draft manuscripts. Strong background in cryo-EM, X-ray crystallography, protein chemistry of soluble and membrane proteins and biophysics is required as well as strong background and knowledge in the field of RTK biology. The Department of Structural Biology has access to state-of-the-art cryo-EM (Titan Krios, Talos Arctica and Talos L120C ) and X-ray centers and has an outstanding infrastructure and expertise in NMR spectroscopy, biophysical analysis, proteomics and metabolomics, and single molecule techniques. St. Jude Children’s Research Hospital offers a remarkable opportunity to perform cutting edge research with outstanding institutional support and exceptional shared core facilities in an environment of open collaboration, educational advancement, and training opportunities. St. Jude is consistently ranked on Fortune Magazine’s and Glassdoor’s “100 Best Places to Work” for companies with 1,000 or more employees. We are located in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. Preferred experience - Experience with molecular biology and molecular cloning techniques including subcloning, site-directed mutagenesis, PCR and DNA manipulation is desired. - Experience with a variety of protein expression platforms, including E. coli, insect cell culture and mammalian expression systems.  - Expert in protein purification by various chromatographic techniques including but not limited to IMAC, IEC, HIC, SEC etc.  - Experience with protein engineering or rational design of recombinant proteins along with characterization techniques (for example MS, SEC-MALs, DSF, DLS, SDS-Page etc.).  - Strong track record of scientific accomplishments demonstrated through publications in highly regarded journals.  - Outstanding organizational and multi-tasking skills; able to manage several projects going simultaneously.  - Maintain familiarity with current scientific literature relevant to the research experiments or project.  - An excellent team-player with strong communication skills and a willingness to mentor others.  
Job ID
46561
Department
Structural Biology
Company
St. Jude Children's Research Hospital
Type
Full Time
During the past five decades, St. Jude has made remarkable progress toward curing childhood cancer and other life-threating diseases. At St. Jude Children’s Research Hospital, we know what can be achieved when the brightest scientific minds face the fewest barriers. That’s why we provide world-class facilities, state-of-the-art technologies, extraordinary support and a collaborative, bench-to-bedside environment where you can see, firsthand, how your science translates into survival for the children we serve. St. Jude Children Research Hospital ensures that scientific progress is never halted from a lack of resources. We are building on that success with a comprehensive strategy to expand our mission, including our reach around the world.    St. Jude Children’s Research Hospital is launching a major new strategic initiative in spatial transcriptomics to support basic scientific and translational research.  At the foundation of this initiative is the establishment of a new spatial transcriptomics shared resource that will be home to some of the most cutting edge technologies in the field. State-of-the art ancillary equipment supporting all platforms and an energetic, talented, multi-disciplinary team to staff the facility synergize together to support the research endeavors of the faculty at St. Jude.   The Director of the Spatial Transcriptomics Shared Resource will take the lead in hiring and training their staff, identifying technologies to introduce to the facility and designing the research space. Once the new facility has been opened, the Director will become deeply involved in a wide array of basic science and translational research projects, enabling world-renowned investigators to answer their scientific questions.  The successful applicant will be responsible for managing the Spatial Transcriptomics Shared Resource and collaborating with faculty and staff on exciting and innovative research projects. Daily responsibilities include managing the accurate and efficient performance of facility staff, including quality control, and instrument maintenance. In addition to the management responsibilities, you are expected to play an integral role in the day to day operations of the laboratory, consulting with researchers to formulate optimal workflows covering acquisition in line with data processing, and data analysis. The Director also designs one-on-one training or education sessions to guide best practices and support productive collaborations across the institution. You will oversee all work performed, and you are expected to maintain extensive knowledge and expertise in current and emerging spatial transcriptomics techniques and the associated protocols. This is a dynamic laboratory environment where you will work with researchers involved in innovative basic and translational research for the fulfillment of our mission: Finding Cures. Saving Children.    
Job ID
46545
Department
Spatial Transcriptomics Core
Company
St. Jude Children's Research Hospital
Type
Full Time
The High Throughput Bioscience (HTB) Center at St. Jude under Director and St. Jude Faculty Member Dr. Taosheng Chen, seeks a senior cell and molecular biologist/chemical biologist to design and implement a variety of cell-based phenotypic screens, ranging from large-scale automated cytotoxicity screens, medium-scale genetic loss-of-function siRNA screens, to focused high-content imaging-based screens. The ideal candidate is familiar with high throughput screening and associated data analysis and quality control, and capable of developing/utilizing novel bioassays to solve challenging biology problems. The HTS Scientist reports to the Director of HTB Center and is expected to independently lead and implement collaborative projects; present or publish research results; and assist the Center Director in managing the daily operation of the Center. The HTB Center consists of those with advanced training in biology, chemistry, and engineering who work together on target identification and validation, assay development, laboratory automation, high-throughput and high-content screening (up to 600K small molecules and genome-scale siRNAs), large-scale data processing, and management of scientific collaborations.  
Job ID
44167
Department
Chemical Biology & Therapeutic
Company
St. Jude Children's Research Hospital
Type
Full Time
We are looking for a Lead Researcher to join the lab of Dr. Downing. The selected person will focus on role of germline and somatic mutations in Core Binding Factor acute myeloid leukemia (CBF-AML) with an t(8;21) translocation. As a Lead Researcher you will have the opportunity to contribute to groundbreaking research and explore the underlying molecular mechanism of one of the more common variants of human acute myeloid leukemia. Candidates must possess a good understanding and experience in molecular biology and biochemistry. Demonstrate advanced skills in designing experiments and knowledge in a substantive area of science or technology. Develop new experimental procedures and publish research results. Participate in the presentation/publication of research results. Keep comprehensive accurate organized and legible records of experimental procedures and results. Assist in data analysis and reduction. Write research reports and/or portions of scientific publications as requested.  Experience in, RNA, DNA and protein manipulation, immunofluorescence, cell culture, retroviral/lentiviral transduction, murine genetics, CRISPR technology, ChIP-seq, CLIP-Seq and next generation sequencing procedures preferred. A publication list of manuscripts indicative of a consistent high level of productivity and examples of the capacity for scientific communication at a professional level is desirable. 
Job ID
44872
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
This is an exciting career opportunity for a Senior Researcher or Lead Researcher to join the laboratory of Dr. Lu Wang, MD, PhD, at St. Jude Children's Research Hospital. The Wang laboratory studies genetic/genomic and epigenetic changes of rare tumors with poorly understood genetics using high-resolution, genome-wide approaches such as whole genome sequencing, whole transcriptome sequencing, methylation array, etc., with an emphasis on clinical translation of potential diagnostic markers and therapeutic targets; and addresses questions in tumorigenesis of recurrent genetic aberrations using in vitro and in vivo experimental approaches.   To succeed in this position, you should have a demonstrated proficiency in basic molecular and cell biology techniques such as DNA/RNA/protein extraction, PCR-based techniques, cell culture, cell transfection, as well as skills in generating and maintaining preclinical models. Experience in NGS library preparation and sequencing data review as well as FACS is highly desired. Previous experience in CRISPR-Cas9 genome editing and iPSCs culture is preferred for exceptional applicants.
Job ID
44941
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time
The department of Pathology at SJCRH is looking for a highly motivated and diligent scientist to join the research staff community. The selected candidate will be directly involved in clinical case data analysis, interpretation and reporting. Liaises with other services and departments to facilitate appropriate test ordering and interpretation. Works as part of a multi-disciplinary healthcare team, including individuals from the departments of Pathology, Computational Biology, Cancer Predisposition, and Oncology. May collaborate with faculty in the development and implementation of research protocols in cancer genetics and genomics. Collaborates in the preparation of clinical validation and protocol documents, as well as manuscripts. Participates in the Pathology Department's method evaluation and independent research.
Job ID
43574
Department
Pathology
Company
St. Jude Children's Research Hospital
Type
Full Time

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