Lead Researcher in Structural Biology - Scott Blanchard Group

The Blanchard laboratory in the Department of Structural Biology at St. Jude Children’s Research Hospital is seeking a highly motivated Lead Researcher with experience in molecular biology, biochemistry and quantitative biophysical techniques.

Our highly interdisciplinary, collaborative, mission-driven environment requires a creative team-oriented individual with strong leadership skills, who would ensure quality operations and our vision to successfully pursue scientific advances.

In this role, the successful candidate will use protein and/or nucleic acid biochemistry, including protein expression, purification, and labeling and/or nucleic acid manipulation and purification. Expert ability to distill, convey and present complex information in a clear and concise manner both verbally and in writing is essential, as well as passion to learn and navigate new research fields.

• A Bachelor’s degree in life science or other physical science is required
• Ph.D is preferred

• Five (5) years of relevant, post-degree work experience is required with a Bachelor's degree
• Two (2) years of relevant post-degree work experience is required with a Master's degree
• No additional experience is required with a PHD

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Publication links:

• Quantifying secondary transport at single-molecule resolution.
• Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.
• Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.
• Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.
• Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.
• A partially-open inward-facing intermediate conformation of LeuT is associated with Na⁺ release and substrate transport.
• Aminoglycoside interactions and impacts on the eukaryotic ribosome.
• Dynamics of P-type ATPase transport revealed by single-molecule FRET.
• Miscoding-induced stalling of substrate translocation on the bacterial ribosome.
• Single-molecule analysis of ligand efficacy in β₂AR-G-protein activation.
• Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging.
• Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.
• Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation.
• Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale.
• Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis.
• Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.
• Transport domain unlocking sets the uptake rate of an aspartate transporter.
• Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex.
• Ultra-stable organic fluorophores for single-molecule research.
• Allosteric control of the ribosome by small-molecule antibiotics.
• Cyanine fluorophore derivatives with enhanced photostability.
• Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.
• Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homologue.

Apply to be a part of the mission of St. Jude Children's Research Hospital: to advance cures, and means of prevention, for pediatric catastrophic diseases through research and treatment. Consistent with the vision of our founder Danny Thomas, no child is denied treatment based on race, religion or a family's ability to pay.