We are recruiting a Structural Biologist to join the efforts in structural determination of protein-ligand complexes and contribute structural biology insights into the mechanism of action of novel chemical probes. The Chen laboratory uses multidisciplinary approaches to study transcriptional regulation by nuclear receptors, including chemical biology approaches to develop chemical modulators, with a goal to understand nuclear receptor-regulated transcription networks and design therapeutic approaches to overcome drug resistance and tumorigenesis in cellular and animal models. The structural biology efforts are expected to synergize with our chemical biology efforts and enable completion of impactful projects (Lin et al., Nature Comm. 2017; Wang et al., J Am Chem Soc. 2021). The Chen lab provides a unique research environment, in addition to basic research, lab members will learn and gain experience in small molecule drug discovery from target validation, chemical probe discovery and optimization to preclinical mechanistic studies. The Senior or Lead Researcher will work in a collaborative and multidisciplinary environment by collaborating with biologists, chemists, and technologists.
The successful candidate will have proved experience in expression construct design, molecular cloning, protein expression and purification, optimization of crystallization conditions, crystallization and structural determination of protein-ligand complexes using X-ray crystallography.
Experience in the following areas is a plus: purification and crystallization of nuclear receptors; synchrotron data collection; biophysical assays; in silico modeling of protein-ligand interactions; preparation of manuscripts; along with a strong publication record.
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
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