Cryo-EM Researcher/Scientist in Programmed Cell Death

Job ID
Structural Biology
Job Location


The Moldoveanu lab is seeking a highly motivated cryo-EM structural biologist to work on interdisciplinary projects at the interface of integrated structural biology and biochemistry of proteins implicated in programmed cell death.


The successful candidate takes a leadership role in applying cryo-EM analysis in characterization of macromolecular complexes implicated in programmed cell death. He or she is expected to:

  • perform all aspects of single particle cryo-EM analysis independently, including negative staining, grid freezing, data collection and processing, and model building and refinement 
  • interpret structures to generate hypothesis for functional investigations
  • prepare and draft relevant sections of papers and grants
  • interface with the cryo-EM center in training new lab members

The ideal candidate will have an academic record of innovative independent research using cryo-EM (papers in the field), hands-on experience with cryo-EM instrumentation, strong background in computational aspects of cryo-EM analysis, experience with sample manipulation for cryo-EM (e.g. purification, crosslinking), excellent oral, presentation, and written communication skills.


The successful candidate will join a highly collaborative team with expertise in biochemistry and structural biology focused on elucidating mechanisms of cell death signaling in the Department of Structural Biology with access to state-of-the-art cryo-EM instrumentation including Titan Krios, Talos Arctica, and Talos L120C. The Department has outstanding infrastructure and expertise in cryo-EM, X-ray crystallography, NMR spectroscopy, protein technologies, proteomics and metabolomics, and single molecule techniques. St. Jude Children’s Research Hospital is a Fortune 100 Best Company to work for. St. Jude offers highly competitive salary and benefits. We are in Memphis, Tennessee, a city newcomers and natives love to call home. It is friendly, affordable, clean, great for young families, and offers excellent quality of life.


Minimum Education

  • Bachelor's degree in relevant scientific area is required.

Minimum Experience


  •  Seven (7) years of relevant post-degree work experience is required.
  • Five (5) years of relevant post-degree work experience is required with a Master's degree.
  • Three (3) years of relevant post-degree work experience is required with a PhD.

 Lead Researcher

  • Five (5) years of relevant, post-degree work experience is required with a Bachelor's degree.
  • Two (2) years of relevant post-degree work experience is required with a Master's degree.
  • No experience is required with a PhD degree.

What We Offer


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Other Information

COVID-19 vaccine:


As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.


EEO Statement:  St. Jude is an Equal Opportunity Employer

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