M. Madan Babu's Group at the Center of Excellence for Data-Driven Discovery and the Department of Structural Biology is seeking a highly driven, full-time Principal/Senior Bioinformatics Research Scientist to serve as the Web Development and Design lead to support the Kalodimos and Babu Groups on the Blue Sky Initiative "Seeing the Invisible in Protein Kinases." This project is supported by $35 million in institutional funding (more information in the St. Jude Strategic Plan 2022–2027). This is a joint project between the Kalodimos Lab and the Babu Group at St Jude.
The project will extend the ultra-high field NMR spectroscopy and biochemistry approaches developed recently by the Kalodimos lab (Science 370, eabc2754, 2020) to study the human kinome. This is a large-scale project that aims to detect and structurally characterize the distinct conformational states populated by kinases, and to dissect the mechanisms of allosteric regulation and those underpinning oncogenic and drug-resistance mutations. This strategy will be integrated with and complemented by data-science and computational approaches developed by the Babu lab (Nature 587, 650, 2020), to systematically characterize the conformational landscape of the human kinome.
The ideal candidate will be an expert in UX/UI design and back-end development of web applications to help scientists visualize, analyze and understand high-dimensional biological data. You will have a strong background in computer science, web development, bioinformatics, or computational biology and truly exceptional skills in designing visualizations to render complex, multi-dimensional biological data interpretable and understandable. You should be able to present or provide links to a strong work portfolio that demonstrates your expertise in designing, building, and deploying insightful web-based applications. You will be a team player and will work as part of an interdisciplinary team of 40 scientists including biochemists, NMR spectroscopists, data scientists and bioinformaticians. Exceptional communication (written and verbal) and critical thinking skills are a must.
When submitting your application, please include your CV and a cover letter, which includes information or a link to a portfolio of past projects.
Ranked #1 in the U.S. in Pediatric Cancer, St. Jude Children's Research Hospital is a NCI-designated Comprehensive Cancer Center, and home to the Pediatric Cancer Genome Project. The St. Jude campus is a truly unique research environment, encompassing state-of-the-art HPC facilities, world-leading oncology basic research, outstanding Shared Resources and Core Facilities and a dedicated translational Chemical Biology and Therapeutics department. The $412M Advanced Research Center, opened in 2021, doubles the campus’ research space and adds support for an additional 1000 employees. There is a vibrant Data Science community at St. Jude, with opportunities to interact with researchers in the Biostatistics and Computational Biology Departments, and tremendous support from the Center for Applied Bioinformatics.
The Department of Structural Biology is building one of the world’s most comprehensive research center for defining molecular structures to understand health and disease at the molecular level. The Department is home to multiple Technology Core Centers (Cryo-EM and Tomography, X-ray, NMR, Single-Molecule Imaging, and Protein Technologies) ready to characterize Data Driven Discoveries.
In this role, the successful candidate will work independently to assist, and where relevant, lead ongoing projects on the Blue Sky Kinase Project. The Principal/Senior Bioinformatics Research Scientist is expected to work efficiently to manage concurrent projects, collaborate extensively, and meticulously document work (e.g., through written reports, presentations, etc.) and code. In addition, this person will be responsible for instructing and managing junior members of the team and delegating tasks to them.
Preferred Skills and Experience:
Principal Bioinformatics Research Scientist
Senior Bioinformatics Research Scientist
St. Jude Children’s Research Hospital is consistently named as one of Fortune magazine and Glassdoor.com’s “Best Places to Work,” as well as “Best Workplace for Women” and “Best Workplace for Diversity.” We are in the heart of Memphis, Tennessee, a vibrant and friendly city at the historic American crossroads of music, trade, food, and culture. Mild winters and beautiful green outdoor spaces are part of the reasons why Forbes recently named Memphis the 4th happiest city in which to work. Low cost of living and high quality of life are other attractions; Money magazine listed Memphis as one of the least expensive cities in which to raise a child. St. Jude facilities and salaries are highly competitive. The Kalodimos and Babu Groups strive to build and maintain a culture of respect, diversity, and inclusion and we strongly feel these values directly contribute to the dynamic and intellectually stimulating scientific environment we can provide.
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
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