Therapeutic Genome Engineering Scientist

Job ID
Job Location


We are seeking outstanding, highly motivated candidates for scientist roles in the new Therapeutic Genome Engineering (TGEn) group that is part of a multidisciplinary team of scientists and clinical researchers to help advance genome editing strategies to treat sickle cell disease to a Phase 1 clinical trial. Our therapeutic pipeline is fueled by internal scientific discoveries directed from “bench-to-bedside” and academic collaborations.


You will have the opportunity to work with a talented interdisciplinary team of scientists to develop a cellular therapy with the goal of treating patients here at St. Jude Children’s Research Hospital and worldwide. The ideal candidate will have a combination of experience with genome editing and human hematopoietic stem cells.


You will have the opportunity to learn about and support new exciting projects such as:

  • Development and optimization of pre-clinical genome editing strategies for sickle adult hemoglobin.
  • Process development and IND-enabling studies (Pharm/Tox)

Apply today! A cover letter is highly recommended.


Please include a cover letter in your application addressed to Dr. Jonathan Yen.




  • Perform studies to improve genome editing and culture of human hematopoietic stem cells. 
  • Design and execute IND-enabling experiments to characterize the pharmacology of a genome edited human hematopoietic stem cell product to treat sickle cell disease. 
  • Characterize the efficacy and potency of the cellular drug product in in vitro and xenotransplantation assays. 
  • Interact and collaborate with multidisciplinary team to advance the program. 
  • Evaluate scale-up and close-system processes to ensure reproducibility of drug product. 
  • Establish tracking and trending analyses of process development and pilot runs. 
  • Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility. 

Minimum Education

  • Three (3) years of relevant post-degree work experience is required with a PhD in Life Sciences, Bioengineering, or related discipline.

Minimum Experience

  • Strong experience and knowledge in hematology and hematopoietic stem cell biology.
  • Experience in cell-based therapy culture and process. 
  • Experience with genome editing tools (Nucleases/base editing) 
  • Ability to communicate effectively with strong communications skills and a collegial personality. 
  • Ability to operate in a fast-paced, multi-disciplinary environment. 
  • Must be an independent thinker, meticulous, detail-oriented, and analytical. 
  • Must be highly motivated, have excellent organizational, communication and interpersonal skills. 
  • Must be able to work independently and as part of a multi-disciplinary team. 

Preferred Qualification

  • cGMP experience in the cell and gene therapy spaces.
  • Experience within biotech/pharmaceutical company or a CRO/CMO.
  • Experience in biologics manufacturing.
  • Knowledge of process development concepts for biological manufacturing; basic principles of various engineering disciplines.
  • Experience in NGS sequencing and data analysis.
  • Experience in automated cell processing systems such as Sepax, CliniMACS Prodigy & Plus, bioreactors, or other cell therapy processing instruments.
  • Familiarity with flow cytometry; analysis and sorting.
  • Animal experience, familiar with humanized mouse xenotransplantation models (NSG/NBSGW) 

What We Offer


Salary is highly competitive (comparable to industry) and employee benefits are outstanding. Relocation assistance is available. Working at St. Jude provides the opportunity to make a tangible difference to pediatric cancer patient care and survival and St. Jude has been consistently ranked in Fortune magazine’s “100 Best Places to Work” list and is exceptionally positively reviewed on GlassDoor.


WHATWE_Benefits          WHATWE_Glassdoor          WHATWE_UnexpectedPerks




Other Information

COVID-19 vaccine:


As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.


EEO Statement:  St. Jude is an Equal Opportunity Employer

No Search Firms:

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.



Sorry the Share function is not working properly at this moment. Please refresh the page and try again later.
Share on your newsfeed

Stay connected

We're breaking new ground at St. Jude. Stay up-to-date on our latest news and career opportunities in the areas you're most interested in by becoming a St. Jude Careers Insider.

Search all St. Jude Jobs, including postdoctoral research fellowships, clinical fellowships and faculty appointments.