• Bioinformatics Research Scientist - Blanchard Lab

    Job ID
    Structural Biology
    Job Location
  • Overview

    St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment of disease that improve the lives of patients. The Department of Structural Biology at St. Jude is seeking a highly motivated and creative bioinformatics scientist to lead our genomics initiatives, using both existing and novel algorithms, to reveal insights into the role of translational control (using genomics and next-generation sequencing methods including RNA-Seq, ribosome profiling, Pro-Seq etc.) in regulating physiological events related to cancer metastasis. Particular emphasis will be given to interrogating the role of non-coding RNAs from multi-copy gene families. The successful applicant will be an integral part of an interdisciplinary team of scientists, collaborating directly with team members to expertly solve data analysis challenges and empower them to make powerful quantitative insights.


    • Perform analysis on clinically relevant biological problems using a variety of bioinformatics workflows, including both genomics and time series data (hidden Markov modeling).
    • Uncover DNA sequence variation in high copy number genes utilizing both existing and novel algorithms for the analysis of RNA-Seq (Illumina) and next-generation DNA sequencing (NGS; e.g., PacBio) data.
    • Characterize genome-wide modulation of the transcriptome and translatome using RNA-Seq and ribosome profiling during cellular differentiation events related to cancer metastasis.
    • Uncover changes in the expression of gene isoforms with highly similar sequences (e.g., PacBio Iso-Seq; Illumina 10X).
    • Collaborate with biologists to provide expertise in the statistical analysis of a variety of data types.
    • Regularly present results at group meetings and conferences and publish results in peer-reviewed journals.  

    Minimum Education

    • Ph.D. in Molecular Biology, Biochemistry, Computer Science, Statistics, Mathematics, Bioinformatics or related field required

    Minimum Experience

    • Ph.D which must include research related to bioinformatics (such as analysis of sequence data, microarrays, SNPs, image data, proteomics data, or biological pathways; development of algorithms, statistical methods, or scientific software); OR If Ph.D with no bioinformatics research, then two (2) years of pre-or postdoctoral experience in Computational Biology or Bioinformatics research is required
    • Experience with programming languages such as Perl, C, or Java required

    Preferred Skills:

    • Thorough knowledge of statistics, probability theory, machine learning algorithms, maximum likelihood optimization, Bayesian methods, and linear algebra.
    • Proficient with R and associated bioinformatics packages (e.g., Bioconductor), MATLAB, and shell scripting.
    • Ability to create compelling graphics, including interactive data visualization tools (e.g. R-Shiny, D3.js).
    • Experience with distributed computing bioinformatics workflows on Unix/Linux and cloud environments.
    • Thorough knowledge of software engineering principles and capability to produce robust, well-documented software with polished user interfaces.
    • Expert ability to distill complex information in a clear and concise manner both verbally and in writing.


    EEO Statement

    St. Jude is an Equal Opportunity Employer

    No Search Firms:

    St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.


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