• Synthetic Organic Chemist

    Job ID
    Structural Biology
  • Overview

    St. Jude Children’s Research Hospital is one of the world’s premier research and treatment centers for pediatric cancer and other life-threatening diseases. It is globally recognized for its pioneering work in pediatric oncology and hematology; genomics; computational biology; immunology; infectious diseases; cell, molecular and structural biology; neurobiology; drug discovery; and global medicine.


    St. Jude Children’s Research Hospital has a unified mission to use cutting-edge research to discover the origins of disease, especially cancer, in order to facilitate advances in the treatment of disease that improve the lives of patients. The Department of Structural Biology is seeking a total synthetic organic chemist to lead chemistry initiatives in Dr. Scott Blanchard’s lab to further develop synthetic control of intra-molecular photo-stabilized fluorescent probes for imaging applications. Qualified applicants will also lead chemical biology initiatives aimed at advancing the mechanistic study of clinically important biological systems at the single-molecule scale. The highly collaborative, hypothesis-driven environment requires a team-oriented individual with strong leadership skills to ensure quality operations as well as the vision and creativity to successfully pursue scientific advances.


    • Design and synthesis of Cyanine- and Rhodamine-class organic fluorophores and other bio-active small molecules.
    • Methodology development and yield optimization for improved syntheses and scaling.
    • Presentation of experimental data, research progress for collaborative publications.
    • Effectively communicate and help advance multidisciplinary team-based research projects
    • Safety guidelines, chemical management, and maintenance of laboratory equipment

    Minimum Education

    • A Ph.D. in an appropriate scientific field, preferably in synthetic organic chemistry or equivalent, is required

    Minimum Experience

    • A minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.

    Preferred Skills

    • Experience in design and performing multiple-step total synthesis from commercially available reagents.
    • Experience in moisture-sensitive reactions, conventional chromatography, HPLC purification, LC-MS, and NMR.
    • Ability to carry out multiple projects and responsibilities in parallel, delegating as appropriate.
    • Expert ability to distill complex information in a clear and concise manner both verbally and in writing.

    EEO Statement

    St. Jude is an Equal Opportunity Employer

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