• Staff Scientist

    Job ID
    Structural Biology
    Job Location
  • Overview

    We are seeking outstanding biochemists with expertise in protein purification and/or protein engineering to join our new Protein Technologies Center (PTC) within the Structural Biology Department at St. Jude Children’s Research Hospital. The PTC is a multidisciplinary team with capabilities in protein engineering, cloning, expression, purification, and analysis of proteins. The PTC is responsible for the optimization, production and assessment of difficult protein targets for structural studies, thereby supporting structural biologists and other researchers at St. Jude to focus on making big discoveries. This is a bench-based scientist role where you will be providing pivotal support to several projects both strategically and tactically.


    The Department of Structural Biology houses state-of-the-art facilities for NMR (1.1GHz), CryoEM (Titan Krios, Artica), X-ray (robots) and Single Molecule (MicroTime 200); the PTC will work in unison with all the centers and will help to tackle important biological questions.


    1. Design, develop and optimize protein expression, purification and characterization methods like stability, size distribution and conformation
    2. Engineer the proteins, including membrane proteins, immune molecules, complex multi-domain proteins and fusion partners (Chimeras) which would aid in the stabilization and/or increase the chance of success in protein production, purification and structure-function studies.
    3. Purification and analysis of the recombinant proteins, preferably membrane proteins, using FPLC and U/HPLC and also maintenance of the chromatography systems
    4. Contribution to the entire structural biology workflow: - cloning and expression in bacteria, insect or mammalian expression systems
    5. Generate antibodies (or Synthetic Antigen Binders) through hybridoma, phage, yeast, or other panning technology
    6. Work independently on the design, execution, and interpretation of experimental results
    7. Train and mentor research associates, students and/or postdoctoral associates who seek to leverage the Protein Technologies Center’s capabilities at St. Jude

    Minimum Education

    PhD in the area of molecular biology, biochemistry, protein engineering, or any related discipline.

    Minimum Experience

    A minimum of five (5) years of relevant and productive (combined) years postdoctoral research associate or five (5) years of combined academic experience at the postdoctoral level or above.

    EEO Statement

    St. Jude is an Equal Opportunity Employer

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