St. Jude Children’s Research Hospital was the first pediatric cancer research center in the U.S. to open its own on-site GMP facility, Children’s GMP, LLC. Now St. Jude, a federally-designated Hemophilia Treatment Center, is working to bring a new hemophilia gene therapy to patients in countries where access to treatment is low and the standard of care is poor. The process development team is working on a novel process to manufacture and purify this new AAV-based gene therapy so the GMP team can manufacture sufficient quantities to meet the clinical research needs in these countries. If successful, this project has the potential to bring a cure to hemophilia B patients in these populations.
The Senior Scientist I will implement downstream process development and characterization experiments with minimal supervision, and maintain experimental details via electronic notebook; oversee day-to-day troubleshooting and maintenance of instrumentation; help to draft production batch records in close collaboration with the Quality Assurance Department of Children’s GMP, LLC; and lend support in cGMP manufacturing.
The ideal candidate has excellent experience in ion-exchange and affinity chromatography methods, including experience on AKTA systems with Unicorn software, filtration, and in process development; displays attention to detail; and is committed to the mission of St. Jude.
Bachelor’s degree in Biological Sciences, Chemical Engineering or Bioprocessing or related field required. MS or Ph.D. preferred.
Eight (8) years of related experience with a BS
Four (4) years of related experience with a MS
No related experience required with a Ph.D
Experience in recombinant virus or protein purification is required, preferably in a GMP environment
Experience with AKTA systems and Unicorn software and with filtration is strongly preferred
Experience with AAV vectors is a plus
Experience with cell culture is a plus
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