• Cryo-EM Specialist

    Job ID
    Structural Biology
    Job Location
  • Overview

    St. Jude is setting up a new, state-of-the-art cryoEM facility that will house a 300kV Titan Krios and a 200 kV Talos Arctica electron microscope, both equipped with a K3 direct electron detector and energy filter, for high resolution structural studies of biological molecules as well as a 120kV instrument for routine electron microscopy applications.  The cryoEM facility will be supported by the newly established St. Jude Data Center, which houses a 6,400-core high performance computing facility.


    We are seeking a highly motivated individual to join the team as a cryoEM scientist to support the mission of the facility in high resolution cryoEM. The successful candidate will be responsible for operating and maintaining those electron microscopes on the daily basis, training and assisting users, participating in development of cryoEM technology, and performing other duties as assigned.  Salary will be competitive and will be commensurate with experience of the candidate.


    • Daily operation and maintenance of electron microscopes, serving as an interface to the electron microscope manufacture’s engineers to ensure optimal performance of the instruments;

    • Operation and maintenance of cryoEM-related ancillary equipment such as Vitrobot, carbon coater, plasma cleaner, etc.

    • Sample preparation with FEI Vitrobot and manual plunger-freezer;

    • CryoEM image collection;

    • Training, assisting and overseeing users in sample preparation and data collection;

    • Managing the cryoEM facility, including, but not limited to organizing the labs, ordering supplies, keeping records, writing reports, and other activities as assigned;

    • Developing and implementing efficient strategies for sample preparation and data collection;

    • Participating in development and implementation of new methods/techniques in cryoEM;

    Minimum Education

    • A PhD in biochemistry, biophysics, structural biology or a related field

    Minimum Experience

    • A minimum of 2-5 years of experience in cryoEM analysis of biological molecules;

    • Hands-on experience in operation of electron microscopes for image collection;

    • Hands-on experience in operation of Vitrobot, manual plunger and/or other related equipment in biological electron microscopy;

    • Experience in high resolution cryoEM;

    • Hands-on experience in usage of cryoEM software such as Leginon for automated image collection;

    • Hands-on experience in operation of Titan Krios and Talos Arctica;

    • Experience in cryo electron tomography a plus;

    • Skills in working and communicating with scientists at all levels;

    • Ability in working on multiple challenging tasks in a rapidly-paced environment.

    • A strong publication record;

    EEO Statement

    St. Jude is an Equal Opportunity Employer

    No Search Firms:

    St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.


    Sorry the Share function is not working properly at this moment. Please refresh the page and try again later.
    Share on your newsfeed

    Stay connected

    We're breaking new ground at St. Jude. Stay up-to-date on our latest news and career opportunities in the areas you're most interested in by becoming a St. Jude Careers Insider.

    Search all St. Jude Jobs, including postdoctoral research fellowships, clinical fellowships and faculty appointments.