St. Jude Children’s Research Hospital’s Department of Developmental Neurobiology is looking for a highly motivated bioinformatics research scientist as the key analyst for the epigenomics and single cell sequencing projects of the Department of Developmental Neurobiology, in close collaboration with the Department of Computational Biology. The goal of the Developmental Neurobiology Department, led by Dr. Michael Dyer, an HHMI investigator, is to understand how neurons are formed during development and how that process can become deregulated in pediatric brain tumors. Emphasis is placed on applying cutting edge computational approaches to some of the most innovative biological studies in the field. Members of the Department of Developmental Neurobiology publish in high profile journals including Nature, Cell, Science, Cancer Cell, Neuron, Nature Neuroscience, Nature Genetics, Cell Stem Cell and many others. The Computational Biology Department has a well-established track record in leading bioinformatics analysis for high-profile genomic and translational research projects such as the St. Jude/Washington University Pediatric Cancer Genome Project. Specific projects include the integrative analysis of ChIP-seq of histone marks and transcription factors, ATAC-seq, Hi-C, Capture-seq, whole-genome and whole exome sequencing, whole transcriptome RNA-seq data to understand the mechanism of key molecular pathways involved in tumorigenesis especially pediatric brain and solid tumors. Candidates with an understanding of epigenomics, clonal analysis and single cell RNA sequencing analysis and with strong problem solving skills, attention to detail, critical thinking, and expertise in next-generation sequencing data analysis are highly encouraged to apply for this position.
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